Entry
Name
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5!Leu-, -Leu6!Cys-, -Ala14!Leu- and -Cys19!Gly- bonds in insulin B chain
Comment
A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin beta subunits (in contrast to meprin A, which contains both alpha and beta subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family)
History
EC 3.4.24.63 created 1995
Orthology
Genes
MDO : 100031050 100031055(MEP1B)
GAS : 123253669 123253691(MEP1B)
SHR : 100920095 100920356 100920611
XLA : 108695280(mep1b.S) 108718576 108718577 108718578 108718579
NPR : 108786081(MEP1B) 108786082 108786083
RTEM : 120940955 120940956
BBUF : 121002163 121002434 121002435
BGAR : 122938859(MEP1B) 122939334 122939336
DRE : 100151009(mep1ba) 327586(si:ch73-40a17.3)
SRX : 107714661 107714662 107723382 107725789
SANH : 107657610 107662546 107677797 107687173
SGH : 107563077 107568554 107571855 107581493 107581508 107596174
CCAR : 109055310 109057735 109091953 109098231 109098394 109105388 109107094 109111380 109112295
CAUA : 113039431 113059708 113060240 113063711 113084155 113084156 113084159 113102986 113102988 113102990 113113425 113116738 113119132 113121069
IPU : 108258155(mep1ba) 108267869 108267871
PHYP : 113545303 113547251 113547287
SMEO : 124376696(mep1ba) 124387068(mep1bb)
TFD : 113662331(mep1bb) 113664000(mep1ba)
AMEX : 103035096 103045306(mep1b) 103047091 103047392
TNG : GSTEN00006435G001 GSTEN00012197G001 GSTEN00020417G001 GSTEN00028305G001
LCO : 104929464 104931537(mep1b) 104939568 104939807 109140401
CGOB : 115020985 115022332
ELY : 117253373 117253635 117253862 117264509 117265345 117266095 117271857(si:ch73-40a17.3)
PLEP : 121938414(mep1bb) 121941335 121945197
SLUC : 116039641 116046032(si:ch73-40a17.3)
ECRA : 117953861(si:ch73-40a17.3)
PFLV : 114545668 114565580(mep1b) 114573819 114573835
GAT : 120810384 120811183 120815780 120823774
PPUG : 119197311 119209164(si:ch73-40a17.3) 119216184(mep1b)
MSAM : 119887102 119887252 119901238 119901240 119901373 119902973
CUD : 121512490(mep1ba) 121514163 121514164 121519949(mep1bb)
MZE : 101464784 101470468(mep1b) 101487076 106674862
ONL : 100696060 100696326 100699674 100705643(mep1b) 100706112 102075759 102080243
OAU : 116309517 116309518 116309519 116309947(mep1ba) 116313761 116318670(mep1bb) 120442723
OLA : 101158971 101167239(mep1b) 101167821 101169582 101173215 105355982 105357310
OML : 112138238 112143593 112143793 112143796 112147067(si:ch73-40a17.3) 112150446 118599840
XMA : 102225947(mep1b) 102233350 102236284 106699905
XCO : 114139666 114141730 114142354 114146571(mep1b) 114151483
XHE : 116716359 116716808 116716810 116717206 116721700(mep1b) 116726251
PRET : 103464018 103477874 103477902 103477905 103479550(mep1b)
PFOR : 103135811(mep1b) 103139244 103139245 103139249 103139250 103141591 103143062 103146697
PLAI : 106938467 106948617(mep1b) 106959843 106960215 106960224 106960439
PMEI : 106908512 106910742 106912957 106917662 106917670 106917671 106917675 106925930(mep1b)
GAF : 122830739 122831136 122831277 122838892 122841237(mep1bb)
CVG : 107082956 107082992 107082993 107083563 107091700 107092415(mep1b)
CTUL : 119777433 119777434 119777435 119787670(mep1b) 119795659(si:ch73-40a17.3) 119797871
GMU : 124866050 124866085 124866137 124869902(mep1bb)
NFU : 107379407 107379683 107383911(mep1b)
KMR : 108235358 108235371 108235372 108235373 108235546 108235548 108239650(si:ch73-40a17.3)
NWH : 119409678 119409679 119414561(mep1bb)
AOCE : 111564199 111568694(mep1b)
CSEM : 103389008 103396279(mep1b) 103398781
POV : 109625364 109633072 109633167 109638837 109648090
SSEN : 122759880 122766408 122769155(mep1bb) 122780674
HHIP : 117759756(mep1b) 117776987 117776988 117778189(si:ch73-40a17.3)
LCF : 108878817 108883415(mep1b) 108898221 108898236 108898245
SDU : 111231107(mep1b) 111231912 111232045 111235801 111236058
SLAL : 111651130 111657249 111670483(mep1b) 111671975
XGL : 120784491 120798892(mep1bb)
BPEC : 110159506(mep1b) 110174420 110174421 110174422 110174423
MALB : 109954644 109954645 109957740
SASA : 106569161(mep1b) 106605693 106605695
OTW : 112235283 112251615(mep1ba) 112260582(mep1bb)
OMY : 110524649(mep1b) 110530435(si:ch73-40a17.3)
OGO : 123997327 124009135(mep1bb)
ONE : 115114525(mep1b) 115142125
SALP : 111956379(mep1b) 112081000
SNH : 120047228 120054335(mep1b) 120055310(si:ch73-40a17.3)
ELS : 105018582 105024313 105026400
AANG : 118225776(mep1b) 118233073
BBEL : 109472514 109481933 109485440
SCLV : 120326385 120335019 120335037 120337642 120344001 120346510
BTAB : 109042629 109042937
PJA : 122260941 122263524 122264039
PTEP : 107446799 122268285
HRF : 124130203 124137440 124137450 124137456 124137461 124137468 124139988 124140217 124140234 124140252
CRG : 105317110 105317922 105319685 105319686 105319688 105343632 117681556 117683148
PMAX : 117332549 117338499 117342714
MMER : 123534631 123536726 123563485 123564247 123564248
NVE : 5500840 5504038 5507767 5516561 5522136 5522147
EPA : 110232881 110232943 110233649 110235540 110236447 110236451 110239576 110243849 110252250 110252268 110253148 110253171 110254049
ATEN : 116287249 116289314 116290639 116293897 116299167 116302414 116303370 116306718 116308851
ADF : 107327597 107331556 107337681 107337762 107346411 107355954
AMIL : 114955870 114956355 114957630 114958349 114965731 114968599
PDAM : 113665203 113667219 113667374 113667665 113680043 113680631 113685877 113685879
SPIS : 111325461 111326164 111330142 111330143 111336311 111337192 111337305 111345792 111345983
DGT : 114518108 114525564 114541320
HMG : 100199496 100200172 100209222(MP2)
» show all
Taxonomy
Reference
Authors
Kounnas MZ, Wolz RL, Gorbea CM, Bond JS.
Title
Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.
Journal
J Biol Chem 266:17350-7 (1991)
Sequence
Reference
Authors
Gorbea CM, Marchand P, Jiang W, Copeland NG, Gilbert DJ, Jenkins NA, Bond JS.
Title
Cloning, expression, and chromosomal localization of the mouse meprin beta subunit.
Journal
J Biol Chem 268:21035-43 (1993)
Sequence
Reference
Authors
Johnson GD, Hersh LB.
Title
Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation.
Journal
J Biol Chem 269:7682-8 (1994)
Reference
Authors
Wolz RL, Bond JS.
Title
Meprins A and B.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.63