KEGG ENZYME: 3.4.24.63

ENZYME: 3.4.24.63

Entry

EC 3.4.24.63 Enzyme

Name

meprin B;
meprin-b

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5!Leu-, -Leu6!Cys-, -Ala14!Leu- and -Cys19!Gly- bonds in insulin B chain

Comment

A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin beta subunits (in contrast to meprin A, which contains both alpha and beta subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family)

History

EC 3.4.24.63 created 1995

Orthology

K08606

meprin B

Genes

HSA:	4225(MEP1B)

PTR:	468515(MEP1B)

PPS:	100991143(MEP1B)

GGO:	101131682(MEP1B)

PON:	100461703(MEP1B)

NLE:	100587715(MEP1B)

MCC:	707036(MEP1B)

MCF:	102120570(MEP1B)

CSAB:

103222566(MEP1B)

RRO:	104664448(MEP1B)

RBB:	108530921(MEP1B)

CJC:	100406280(MEP1B)

SBQ:	101032707(MEP1B)

MMU:	17288(Mep1b)

RNO:	25727(Mep1b)

CGE:	100774490(Mep1b)

NGI:	103730584(Mep1b)

HGL:	101721966(Mep1b)

CCAN:

109700569(Mep1b)

OCU:	100349918(MEP1B)

TUP:	102501249(MEP1B)

CFA:	490497(MEP1B)

AML:	100474827(MEP1B)

UMR:	103665002(MEP1B)

ORO:	101362685(MEP1B)

FCA:	101089149(MEP1B)

PTG:	102972887(MEP1B)

AJU:	106984962(MEP1B)

BTA:	540701(MEP1B)

BOM:	102277511(MEP1B)

BIU:	109577975(MEP1B)

PHD:	102342891(MEP1B)

CHX:	102181352(MEP1B)

OAS:	101114072(MEP1B)

SSC:	100516141(MEP1B)

CFR:	102509020(MEP1B)

CDK:	105087045(MEP1B)

BACU:

102999400(MEP1B)

LVE:	103090304(MEP1B)

OOR:	101287646(MEP1B)

ECB:	100052389(MEP1B)

EPZ:	103558347(MEP1B)

EAI:	106833999(MEP1B)

MYB:	102262211(MEP1B)

MYD:	102761324(MEP1B)

HAI:	109387887(MEP1B)

RSS:	109435906(MEP1B)

PALE:

102878505(MEP1B)

LAV:	100656666(MEP1B)

TMU:

101351008

MDO:	100031055(MEP1B)

SHR:	100920095 100920356 100920611(MEP1B)

OAA:	100084811(MEP1B)

GGA:	421097(MEP1B)

MGP:	100545010(MEP1B)

CJO:	107310133(MEP1B)

APLA:

101794200(MEP1B)

ACYG:

106038392(MEP1B)

TGU:	100227825(MEP1B)

GFR:	102041784(MEP1B)

FAB:	101820401(MEP1B)

PHI:	102106845(MEP1B)

PMAJ:

107200153(MEP1B)

CCAE:

111924898(MEP1B)

CCW:	104690416(MEP1B)

FPG:	101920674(MEP1B)

FCH:	102052375(MEP1B)

CLV:	102096310(MEP1B)

EGZ:	104126872(MEP1B)

AAM:	106494484(MEP1B)

ASN:	102371434(MEP1B)

AMJ:	102574106(MEP1B)

PSS:	102456515(MEP1B)

CMY:	102938685(MEP1B)

CPIC:

101930949(MEP1B)

ACS:	100563868(mep1b)

PVT:	110077651(MEP1B)

PBI:	103049257(MEP1B)

GJA:	107113251(MEP1B)

XLA:	108695280 108718576 108718577 108718578 108718579

XTR:	100124942(mep1b)

NPR:	108786081(MEP1B) 108786082 108786083

DRE:	100151009(mep1b) 327586(si:ch73-40a17.3)

SRX:	107712835 107714661 107714662 107723382 107725789 107728138 107728528 107754732

SANH:

107657610 107662546 107677797 107685896 107687173

SGH:	107563077 107568554 107571855 107578848 107581493 107581508 107582168 107596174

CCAR:

109055310 109056704 109057735 109068124 109072846 109091953 109092390 109098231 109098394 109105388 109107094 109111380 109112295

IPU:	108258155(mep1b) 108267869 108267871

AMEX:

103035096 103045306(mep1b) 103047091 103047392

TRU:	101073548 101077603

TNG:	GSTEN00006435G001 GSTEN00012197G001 GSTEN00020417G001 GSTEN00028305G001

LCO:	104929464 104931537(mep1b) 104934584 104939568 104939807 104940145 109140401

NCC:	104947934(mep1b)

MZE:	101464784 101470468(mep1b) 101487076 106674862

OLA:	101158971 101167239(mep1b) 101167821 101169582 101173215 105355982 105357310

XMA:	102225947(mep1b) 102233350 102236284 106699905

PRET:

103464018 103477874 103477902 103477905 103479550(mep1b)

NFU:	107379407 107379683 107383911(mep1b)

KMR:	108235358 108235371 108235372 108235373 108235546 108235548 108239650(mep1b)

CSEM:

103389008 103396279(mep1b) 103398781

LCF:	108878817 108883415(mep1b) 108898221 108898236 108898245

SDU:	111231107(mep1b) 111231912 111232045 111235801 111236058

HCQ:	109521233(mep1b)

BPEC:

110159506(mep1b) 110174420 110174421 110174422 110174423

MALB:

109954644 109954645 109957740 109972189

SASA:

106569161(mep1b) 106605674 106605676 106605693 106605695

OTW:	112235283 112260582

ELS:	105018582 105024313 105026400

SFM:	108937645(mep1b)

LCM:	102349308(MEP1B)

CMK:	103191077(mep1b)

BFO:	BRAFLDRAFT_102513

CIN:

CLEC:

ZNE:

TUT:

LGI:	LOTGIDRAFT_194410

CRG:	105317922 105319685 105319686 105319688 105346200

MYI:	110441919 110442536 110452104

OBI:

106872752

NVE:	NEMVE_v1g120119

EPA:	110232881 110232943 110233649 110239576 110242500 110246877 110252250 110254049

ADF:	107331556 107346411

HMG:	100199496 100209222(MP2)

AQU:

109580701

» show all

Reference

1 [PMID:1894622]

Authors

Kounnas MZ, Wolz RL, Gorbea CM, Bond JS.

Title

Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.

Journal

J Biol Chem 266:17350-7 (1991)

Sequence

[mmu:17288]

Reference

2 [PMID:8407940]

Authors

Gorbea CM, Marchand P, Jiang W, Copeland NG, Gilbert DJ, Jenkins NA, Bond JS.

Title

Cloning, expression, and chromosomal localization of the mouse meprin beta subunit.

Journal

J Biol Chem 268:21035-43 (1993)

Sequence

[mmu:17288]

Reference

3 [PMID:7510289]

Authors

Johnson GD, Hersh LB.

Title

Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation.

Journal

J Biol Chem 269:7682-8 (1994)

Reference

4 [PMID:7674930]

Authors

Wolz RL, Bond JS.

Title

Meprins A and B.

Journal

Methods Enzymol 248:325-45 (1995)

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.63

IUBMB Enzyme Nomenclature:

3.4.24.63

ExPASy - ENZYME nomenclature database:

3.4.24.63

BRENDA, the Enzyme Database:

3.4.24.63

CAS:	150679-52-0

DBGET integrated database retrieval system