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Entry
EC 3.4.24.63                Enzyme                                 

Name
meprin B;
meprin-b
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His5!Leu-, -Leu6!Cys-, -Ala14!Leu- and -Cys19!Gly- bonds in insulin B chain
Comment
A brush border membrane-bound metalloendopeptidase known from the intestine of all mouse strains that have been tested, and the kidney of certain inbred strains. A tetramer of meprin beta subunits (in contrast to meprin A, which contains both alpha and beta subunits). Occurs in the kidney as a proenzyme that can be activated by trypsin. Meprin B is inhibited by both EDTA and 1,10-phenanthroline, but not by phosphoramidon, captopril or thiorphan. In peptidase family M12 (astacin family)
History
EC 3.4.24.63 created 1995
Orthology
K08606  meprin B
Genes
HSA: 4225(MEP1B)
PTR: 468515(MEP1B)
PPS: 100991143(MEP1B)
GGO: 101131682(MEP1B)
PON: 100461703(MEP1B)
NLE: 100587715(MEP1B)
MCC: 707036(MEP1B)
MCF: 102120570(MEP1B)
CSAB: 103222566(MEP1B)
RRO: 104664448(MEP1B)
RBB: 108530921(MEP1B)
CJC: 100406280(MEP1B)
SBQ: 101032707(MEP1B)
MMU: 17288(Mep1b)
RNO: 25727(Mep1b)
CGE: 100774490(Mep1b)
NGI: 103730584(Mep1b)
HGL: 101721966(Mep1b)
CCAN: 109700569(Mep1b)
OCU: 100349918(MEP1B)
TUP: 102501249(MEP1B)
CFA: 490497(MEP1B)
AML: 100474827(MEP1B)
UMR: 103665002(MEP1B)
ORO: 101362685(MEP1B)
FCA: 101089149(MEP1B)
PTG: 102972887(MEP1B)
AJU: 106984962(MEP1B)
BTA: 540701(MEP1B)
BOM: 102277511(MEP1B)
BIU: 109577975(MEP1B)
PHD: 102342891(MEP1B)
CHX: 102181352(MEP1B)
OAS: 101114072(MEP1B)
SSC: 100516141(MEP1B)
CFR: 102509020(MEP1B)
CDK: 105087045(MEP1B)
BACU: 102999400(MEP1B)
LVE: 103090304(MEP1B)
OOR: 101287646(MEP1B)
ECB: 100052389(MEP1B)
EPZ: 103558347(MEP1B)
EAI: 106833999(MEP1B)
MYB: 102262211(MEP1B)
MYD: 102761324(MEP1B)
HAI: 109387887(MEP1B)
RSS: 109435906(MEP1B)
PALE: 102878505(MEP1B)
LAV: 100656666(MEP1B)
TMU: 101351008
MDO: 100031055(MEP1B)
SHR: 100920095 100920356 100920611(MEP1B)
OAA: 100084811(MEP1B)
GGA: 421097(MEP1B)
MGP: 100545010(MEP1B)
CJO: 107310133(MEP1B)
APLA: 101794200(MEP1B)
ACYG: 106038392(MEP1B)
TGU: 100227825(MEP1B)
SCAN: 103816093(MEP1B)
GFR: 102041784(MEP1B)
FAB: 101820401(MEP1B)
PHI: 102106845(MEP1B)
PMAJ: 107200153(MEP1B)
CCAE: 111924898(MEP1B)
CCW: 104690416(MEP1B)
FPG: 101920674(MEP1B)
FCH: 102052375(MEP1B)
CLV: 102096310(MEP1B)
EGZ: 104126872(MEP1B)
NNI: 104019801(MEP1B)
ACUN: 113476445(MEP1B)
AAM: 106494484(MEP1B)
ASN: 102371434(MEP1B)
AMJ: 102574106(MEP1B)
PSS: 102456515(MEP1B)
CMY: 102938685(MEP1B)
CPIC: 101930949(MEP1B)
ACS: 100563868(mep1b)
PVT: 110077651(MEP1B)
PBI: 103049257(MEP1B)
GJA: 107113251(MEP1B)
XLA: 108695280 108718576 108718577 108718578 108718579
XTR: 100124942(mep1b)
NPR: 108786081(MEP1B) 108786082 108786083
DRE: 100151009(mep1b) 327586(si:ch73-40a17.3)
SRX: 107712835 107714661 107714662 107723382 107725789 107728138 107728528 107754732
SANH: 107657610 107662546 107677797 107685896 107687173
SGH: 107563077 107568554 107571855 107578848 107581493 107581508 107582168 107596174
CCAR: 109055310 109056704 109057735 109068124 109072846 109091953 109092390 109098231 109098394 109105388 109107094 109111380 109112295
IPU: 108258155(mep1b) 108267869 108267871
PHYP: 113545303 113547251 113547287
AMEX: 103035096 103045306(mep1b) 103047091 103047392
EEE: 113582970(mep1b)
TRU: 101073548 101077603
TNG: GSTEN00006435G001 GSTEN00012197G001 GSTEN00020417G001 GSTEN00028305G001
LCO: 104929464 104931537(mep1b) 104939568 104939807 104940145 109140401
NCC: 104947934(mep1b)
MZE: 101464784 101470468(mep1b) 101487076 106674862
OLA: 101158971 101167239(mep1b) 101167821 101169582 101173215 105355982 105357310
XMA: 102225947(mep1b) 102233350 102236284 106699905
PRET: 103464018 103477874 103477902 103477905 103479550(mep1b)
NFU: 107379407 107379683 107383911(mep1b)
KMR: 108235358 108235371 108235372 108235373 108235546 108235548 108239650(mep1b)
CSEM: 103389008 103396279(mep1b) 103398781
LCF: 108878817 108883415(mep1b) 108898221 108898236 108898245
SDU: 111231107(mep1b) 111231912 111232045 111235801 111236058
HCQ: 109521233(mep1b)
BPEC: 110159506(mep1b) 110174420 110174421 110174422 110174423
MALB: 109954644 109954645 109957740 109972189
SASA: 106569161(mep1b) 106605674 106605676 106605693 106605695
OTW: 112235283 112260582
SALP: 111956379(mep1b) 112081000
ELS: 105018582 105024313 105026400
SFM: 108937645(mep1b)
PKI: 111845993(mep1b)
LCM: 102349308(MEP1B)
CMK: 103191077(mep1b)
BFO: BRAFLDRAFT_102513
CIN: 100179459
CLEC: 106668216
ZNE: 110830837
TUT: 107360299
LGI: LOTGIDRAFT_194410
CRG: 105317922 105319685 105319686 105319688 105346200
MYI: 110441919 110442536 110452104
OBI: 106872752
NVE: NEMVE_v1g120119
EPA: 110232881 110232943 110233649 110239576 110242500 110246877 110252250 110254049
ADF: 107331556 107346411
PDAM: 113665203 113667374 113680043 113680631 113686839
SPIS: 111326164 111330406 111336311 111337192 111337305 111345792 111345983
HMG: 100199496 100209222(MP2)
AQU: 109580701
 » show all
Taxonomy
Reference
1  [PMID:1894622]
  Authors
Kounnas MZ, Wolz RL, Gorbea CM, Bond JS.
  Title
Meprin-A and -B. Cell surface endopeptidases of the mouse kidney.
  Journal
J Biol Chem 266:17350-7 (1991)
  Sequence
[mmu:17288]
Reference
2  [PMID:8407940]
  Authors
Gorbea CM, Marchand P, Jiang W, Copeland NG, Gilbert DJ, Jenkins NA, Bond JS.
  Title
Cloning, expression, and chromosomal localization of the mouse meprin beta subunit.
  Journal
J Biol Chem 268:21035-43 (1993)
  Sequence
[mmu:17288]
Reference
3  [PMID:7510289]
  Authors
Johnson GD, Hersh LB.
  Title
Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation.
  Journal
J Biol Chem 269:7682-8 (1994)
Reference
4  [PMID:7674930]
  Authors
Wolz RL, Bond JS.
  Title
Meprins A and B.
  Journal
Methods Enzymol 248:325-45 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.63
IUBMB Enzyme Nomenclature: 3.4.24.63
ExPASy - ENZYME nomenclature database: 3.4.24.63
BRENDA, the Enzyme Database: 3.4.24.63
CAS: 150679-52-0

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Protein sequence (13)   
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3D Structure (2)   
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