KEGG   ENZYME: 3.4.24.65Help
Entry
EC 3.4.24.65                Enzyme                                 

Name
macrophage elastase;
metalloelastase;
human macrophage metalloelastase (HME)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of soluble and insoluble elastin [1]. Specific cleavages are also produced at -Ala14!Leu- and -Tyr16!Leu- in the B chain of insulin [2]
Comment
This enzyme is synthesized as a proenzyme of 53 kDa that is converted to an active form of 22 kDa. cDNA sequences have been obtained for the mouse [3] and human [4] enzymes. In peptidase family M10 (interstitial collagenase family)
History
EC 3.4.24.65 created 1995
Orthology
K01413  matrix metalloproteinase-12 (macrophage elastase)
Genes
HSA: 4321(MMP12)
PTR: 451512(MMP12)
PPS: 100994913(MMP12)
GGO: 101133109(MMP12)
PON: 100462632(MMP12)
NLE: 100584628(MMP12)
MCC: 703867(MMP12)
MCF: 102143437(MMP12)
CSAB: 103248345(MMP12)
RRO: 104674669(MMP12)
RBB: 108514065(MMP12)
CJC: 100396585(MMP12)
SBQ: 101050929(MMP12)
MMU: 17381(Mmp12)
RNO: 117033(Mmp12)
CGE: 100754279(Mmp12)
NGI: 103731687(Mmp12)
HGL: 101716268(Mmp12)
CCAN: 109689284(Mmp12)
OCU: 100009559(MMP12)
TUP: 102488657(MMP12)
CFA: 611789(MMP12)
AML: 100481430(MMP12)
UMR: 103662451(MMP12)
ORO: 101370778(MMP12)
FCA: 101084472(MMP12)
PTG: 102969995(MMP12)
AJU: 106976504(MMP12)
BTA: 526981(MMP12)
BOM: 102287756(MMP12)
BIU: 109569210(MMP12)
PHD: 102338210(MMP12)
CHX: 102170339(MMP12)
OAS: 101119157(MMP12)
SSC: 100101475(MMP12)
CFR: 102520612(MMP12)
CDK: 105087167(MMP12)
BACU: 103015358(MMP12)
LVE: 103089572
ECB: 100069047(MMP12)
EPZ: 103552638(MMP12)
EAI: 106843109(MMP12)
MYB: 102253777(MMP12)
MYD: 102753087(MMP12)
HAI: 109378283
RSS: 109437748(MMP12)
PALE: 102886383(MMP12)
LAV: 100660591(MMP12)
TMU: 101341017
MDO: 100012514(MMP12)
SHR: 100915322
PRET: 103476177
 » show all
Taxonomy
Reference
1  [PMID:7030312]
  Authors
Banda MJ, Werb Z.
  Title
Mouse macrophage elastase. Purification and characterization as a metalloproteinase.
  Journal
Biochem J 193:589-605 (1981)
Reference
2  [PMID:7032505]
  Authors
Kettner C, Shaw E, White R, Janoff A.
  Title
The specificity of macrophage elastase on the insulin B-chain.
  Journal
Biochem J 195:369-72 (1981)
Reference
3  [PMID:1537850]
  Authors
Shapiro SD, Griffin GL, Gilbert DJ, Jenkins NA, Copeland NG, Welgus HG, Senior RM, Ley TJ.
  Title
Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.
  Journal
J Biol Chem 267:4664-71 (1992)
  Sequence
[mmu:17381]
Reference
4  [PMID:8226919]
  Authors
Shapiro SD, Kobayashi DK, Ley TJ.
  Title
Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.
  Journal
J Biol Chem 268:23824-9 (1993)
  Sequence
[hsa:4321]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.65
IUBMB Enzyme Nomenclature: 3.4.24.65
ExPASy - ENZYME nomenclature database: 3.4.24.65
BRENDA, the Enzyme Database: 3.4.24.65
CAS: 9004-06-2

DBGET integrated database retrieval system