KEGG   ENZYME: 3.4.24.73Help
Entry
EC 3.4.24.73                Enzyme                                 

Name
jararhagin;
HF2-proteinase;
JF1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of -His10!Leu-, -Ala14!Leu-, -Tyr16!Leu-and -Phe24!Phe- bonds in insulin B chain
Comment
Hemorrhagic endopeptidase from the venom of the jararaca snake (Bothrops jararaca). The 52-kDa enzyme contains a disintegrin domain [3]. In peptidase family M12 (astacin family)
History
EC 3.4.24.73 created 1996
Orthology
K20139  jararhagin
Reference
1
  Authors
Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T.
  Title
Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca.
  Journal
In: Ohsaka, A., Hayashi, K. and Sawai, Y. (Eds.), Animal, Plant and Microbial Toxins, Plenum Press, New York, 1976, p. 111-121.
Reference
2  [PMID:3810664]
  Authors
Assakura MT, Reichl AP, Mandelbaum FR.
  Title
Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca).
  Journal
Toxicon 24:943-6 (1986)
DOI:10.1016/0041-0101(86)90094-2
Reference
3  [PMID:1385408]
  Authors
Paine MJ, Desmond HP, Theakston RD, Crampton JM.
  Title
Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family.
  Journal
J Biol Chem 267:22869-76 (1992)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.73
IUBMB Enzyme Nomenclature: 3.4.24.73
ExPASy - ENZYME nomenclature database: 3.4.24.73
BRENDA, the Enzyme Database: 3.4.24.73
CAS: 160477-79-2

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