KEGG   ENZYME: 3.4.24.75Help
Entry
EC 3.4.24.75                Enzyme                                 

Name
lysostaphin;
glycyl-glycine endopeptidase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of the -Gly!Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans
Comment
A zinc-dependent, 25-kDa endopeptidase from Staphylococcus simulans. Lyses cells of S. aureus, in particular, by its action on the cross-bridges of the cell wall. Type example of peptidase family M23.
History
EC 3.4.24.75 created 1997
Orthology
K08259  lysostaphin
Genes
HAR: HEAR2799
SAU: SA0265(lytM)
SAV: SAV0276(lytM)
SAW: SAHV_0274(lytM)
SAH: SaurJH1_0267
SAJ: SaurJH9_0260
SAM: MW0252(lytM)
SAS: SAS0252
SAR: SAR0273(lytM)
SAC: SACOL0263(lytM)
SAX: USA300HOU_0289(lytM)
SAA: SAUSA300_0270(lytM)
SAE: NWMN_0210(lytM)
SAD: SAAV_0244(lytM)
SUE: SAOV_0217(lytM)
SUC: ECTR2_237
SUQ: HMPREF0772_10224(lytM)
SUZ: MS7_0267(lytM)
SUX: SAEMRSA15_02350(lytM)
SUW: SATW20_02780(lytM)
SUG: SAPIG0291
SUF: SARLGA251_02400(lytM)
SAUA: SAAG_00758
SAUE: RSAU_000222(lytM)
SAUS: SA40_0234(lytM)
SAUU: SA957_0249(lytM)
SAUG: SA268_0246(lytM)
SAUZ: SAZ172_0279(lytM)
SAUT: SAI1T1_2002140(lytM)
SAUJ: SAI2T2_1002140(lytM)
SAUK: SAI3T3_1002140(lytM)
SAUQ: SAI4T8_1002140(lytM)
SAUF: X998_0253(lytM)
SAB: SAB0215(lytM)
SUY: SA2981_0276(lytM)
SAUB: C248_0266(lytM)
SAUM: BN843_2760
SAUC: CA347_282(lytM)
SAUR: SABB_01575(lytM)
SAUI: AZ30_01395
SAUD: CH52_04340
SCA: SCA_2377(lytM)
SHU: SHYC_11995(lytM)
 » show all
Taxonomy
Reference
1  [PMID:3547405]
  Authors
Recsei PA, Gruss AD, Novick RP.
  Title
Cloning, sequence, and expression of the lysostaphin gene from Staphylococcus simulans.
  Journal
Proc Natl Acad Sci U S A 84:1127-31 (1987)
DOI:10.1073/pnas.84.5.1127
  Sequence
Reference
2  [PMID:8890152]
  Authors
Baba T, Schneewind O.
  Title
Target cell specificity of a bacteriocin molecule: a C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus.
  Journal
EMBO J 15:4789-97 (1996)
Reference
3  [PMID:9106216]
  Authors
Thumm G, Gotz F.
  Title
Studies on prolysostaphin processing and characterization of the lysostaphin immunity factor (Lif) of Staphylococcus simulans biovar staphylolyticus.
  Journal
Mol Microbiol 23:1251-65 (1997)
DOI:10.1046/j.1365-2958.1997.2911657.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.75
IUBMB Enzyme Nomenclature: 3.4.24.75
ExPASy - ENZYME nomenclature database: 3.4.24.75
BRENDA, the Enzyme Database: 3.4.24.75
CAS: 9011-93-2

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