KEGG   ENZYME: 3.4.24.79Help
Entry
EC 3.4.24.79                Enzyme                                 

Name
pappalysin-1;
insulin-like growth factor binding protein-4 protease;
pregnancy-associated plasma protein-A
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of the Met135!Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143!Lys bond in IGFBP-5
Comment
A 400-kDa disulfide-linked dimer. Circulates in human pregnancy mainly as a complex with the proform of eosinophil major basic protein, which acts as an inhibitor of the peptidase. The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the presence of insulin-like growth factor (IGF), whereas that of IGFBP-5 is decreased about two-fold. In peptidase family M43.
History
EC 3.4.24.79 created 2003
Orthology
K07762  pappalysin-1
Genes
HSA: 5069(PAPPA)
PTR: 464690(PAPPA)
PPS: 100989941(PAPPA)
GGO: 101151353(PAPPA)
PON: 100454210(PAPPA)
NLE: 100599572(PAPPA)
MCC: 706783(PAPPA)
MCF: 102116695(PAPPA)
CSAB: 103218946(PAPPA)
RRO: 104676244(PAPPA)
RBB: 108518105(PAPPA)
CJC: 100415163(PAPPA)
SBQ: 101044810(PAPPA)
MMU: 18491(Pappa)
RNO: 313262(Pappa)
CGE: 100764393(Pappa)
NGI: 103734508(Pappa)
HGL: 101725271(Pappa)
OCU: 100354636(PAPPA)
TUP: 102480063(PAPPA)
CFA: 481692(PAPPA)
AML: 100477297(PAPPA)
UMR: 103670499(PAPPA)
ORO: 101374374(PAPPA)
FCA: 101089154(PAPPA)
PTG: 102961547(PAPPA)
AJU: 106978598(PAPPA)
BTA: 282647(PAPPA)
BOM: 102283218(PAPPA)
BIU: 109562606(PAPPA)
PHD: 102322695(PAPPA)
CHX: 102179947(PAPPA)
OAS: 443157(PAPPA)
SSC: 397219(PAPPA)
CFR: 102522604(PAPPA)
CDK: 105103770(PAPPA)
BACU: 103018301(PAPPA)
LVE: 103074012(PAPPA)
OOR: 101288391(PAPPA)
ECB: 100033920(PAPPA)
EPZ: 103562342(PAPPA)
EAI: 106824182(PAPPA)
MYB: 102257568(PAPPA)
MYD: 102755027(PAPPA)
HAI: 109390422(PAPPA)
RSS: 109447149(PAPPA)
PALE: 102898449(PAPPA)
LAV: 100658753(PAPPA)
TMU: 101344608
MDO: 100014138(PAPPA)
SHR: 100925831(PAPPA)
OAA: 100077262(PAPPA)
GGA: 417245(PAPPA)
MGP: 100540557(PAPPA)
CJO: 107321647(PAPPA)
APLA: 101793026(PAPPA)
ACYG: 106037103(PAPPA)
TGU: 100232076(PAPPA)
GFR: 102037157(PAPPA)
FAB: 101821477(PAPPA)
PHI: 102100804(PAPPA)
PMAJ: 107212215(PAPPA)
CCAE: 111936938(PAPPA)
CCW: 104688242(PAPPA)
FPG: 101917201(PAPPA)
FCH: 102056110(PAPPA)
CLV: 102097499(PAPPA)
EGZ: 104122723(PAPPA)
AAM: 106493705(PAPPA)
ASN: 102384442(PAPPA)
AMJ: 106736909(PAPPA)
PSS: 102447252(PAPPA)
CMY: 102941026(PAPPA)
CPIC: 101949939(PAPPA)
PBI: 103050788(PAPPA)
GJA: 107107319(PAPPA)
XTR: 100495014(pappa)
NPR: 108805021(PAPPA)
DRE: 101448000(pappaa) 101448001(pappab)
IPU: 108255326 108260258(pappa)
AMEX: 103022238 103040342(pappa)
TRU: 101070582(pappa)
LCO: 104917988(pappa)
NCC: 104953055(pappa) 104953790
MZE: 101485105(pappa)
OLA: 101172349(pappa)
XMA: 102235992(pappa)
PRET: 103473832(pappa)
NFU: 107374593(pappa)
KMR: 108230859(pappa)
CSEM: 103390249(pappa)
LCF: 108874475(pappa)
SDU: 111239570(pappa)
HCQ: 109521665(pappa)
BPEC: 110160531(pappa)
MALB: 109960672(pappa)
LCM: 102365919(PAPPA)
CMK: 103180420(pappa)
APLC: 110976292
SKO: 100368886
EPA: 110254907
ADF: 107344760
ANI: AN6426.2
 » show all
Taxonomy
Reference
1  [PMID:10077652]
  Authors
Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, Yates JR 3rd, Conover CA.
  Title
The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A.
  Journal
Proc Natl Acad Sci U S A 96:3149-53 (1999)
DOI:10.1073/pnas.96.6.3149
  Sequence
[hsa:5069]
Reference
2  [PMID:11897673]
  Authors
Chen BK, Overgaard MT, Bale LK, Resch ZT, Christiansen M, Oxvig C, Conover CA.
  Title
Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible inhibitor.
  Journal
Endocrinology 143:1199-205 (2002)
DOI:10.1210/endo.143.4.8729
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.79
IUBMB Enzyme Nomenclature: 3.4.24.79
ExPASy - ENZYME nomenclature database: 3.4.24.79
BRENDA, the Enzyme Database: 3.4.24.79

DBGET integrated database retrieval system