KEGG   ENZYME: 3.4.24.80Help
Entry
EC 3.4.24.80                Enzyme                                 

Name
membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain
Comment
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.
History
EC 3.4.24.80 created 2003
Orthology
K07763  matrix metalloproteinase-14 (membrane-inserted)
Genes
HSA: 4323(MMP14)
PTR: 742887(MMP14)
PPS: 100990208(MMP14)
GGO: 101142469(MMP14)
PON: 100171646(MMP14)
NLE: 100606407(MMP14)
MCC: 712429(MMP14)
MCF: 102132205(MMP14)
CSAB: 103231446(MMP14)
RRO: 104674133(MMP14)
RBB: 108523596(MMP14)
CJC: 100389088(MMP14)
SBQ: 101041075(MMP14)
MMU: 17387(Mmp14)
MCAL: 110309210(Mmp14)
MPAH: 110325048(Mmp14)
RNO: 81707(Mmp14)
MUN: 110550039(Mmp14)
CGE: 100689336(Mmp14)
NGI: 103739479(Mmp14)
HGL: 101723795(Mmp14)
CCAN: 109685808(Mmp14) 109689717
OCU: 100009598(MMP14)
TUP: 102468813(MMP14)
CFA: 403823(MMP14)
VVP: 112926491(MMP14)
AML: 100468621(MMP14)
UMR: 103681059(MMP14)
UAH: 113246072(MMP14)
ORO: 101369821(MMP14)
FCA: 101089776(MMP14)
PTG: 102953674(MMP14)
AJU: 106988210(MMP14)
BTA: 281915(MMP14)
BOM: 102281987(MMP14)
BIU: 109564819(MMP14)
BBUB: 102413520(MMP14)
PHD: 102321416(MMP14)
CHX: 100861171(MMP14)
OAS: 443116(MMP14)
SSC: 397471(MMP14)
CFR: 102513570 102524386(MMP14)
CDK: 105096970(MMP14)
BACU: 103003307(MMP14)
LVE: 103081188(MMP14)
OOR: 101284790(MMP14)
DLE: 111164185(MMP14)
PCAD: 102987825(MMP14)
ECB: 100034170(MMP14)
EPZ: 103556751(MMP14)
EAI: 106840662(MMP14)
MYB: 102240202(MMP14)
MYD: 102761559(MMP14)
MNA: 107531691(MMP14)
HAI: 109393698(MMP14)
RSS: 109458321(MMP14)
DRO: 112301504(MMP14)
PALE: 102887003(MMP14)
RAY: 107498042(MMP14)
LAV: 100671131(MMP14)
TMU: 101345768
MDO: 100030382(MMP14)
SHR: 100932143(MMP14)
PCW: 110223023(MMP14)
OAA: 100091029(MMP14)
CJO: 107307506
LSR: 110481924
PHI: 102107021(MMP14)
ASN: 102368749(MMP14)
AMJ: 102558609(MMP14)
CMY: 102943947
CPIC: 101945719(MMP14)
ACS: 100553534(mmp14)
PVT: 110087815(MMP14)
PBI: 103064383(MMP14)
PMUR: 107295092(MMP14)
GJA: 107109121(MMP14)
XLA: 108707025 407753(mmp14.L)
XTR: 594950(mmp14)
NPR: 108786770(MMP14)
DRE: 373882(mmp14a) 566945(mmp14b)
SRX: 107706348 107734796 107738136 107753930
SANH: 107668983 107669100 107683283 107691938 107704286
SGH: 107557973 107562471(mmp14) 107588203 107591383
CCAR: 109060080 109064679 109111707 109111713
IPU: 108267723 108267832 108267934(mmp14)
PHYP: 113525614 113540329
AMEX: 103024760(mmp14) 103041213
EEE: 113578328 113589197(mmp14)
TRU: 101061607 101073560
TNG: GSTEN00000363G001 GSTEN00015140G001 GSTEN00025878G001
LCO: 104927972 104932902
NCC: 104952609 104952619 104956583
MZE: 101464934 101486213
OLA: 100125428(mmp14) 101171699
XMA: 102236291 102236856
XCO: 114146537 114157472
PRET: 103475992 103478877
NFU: 107377284(mmp14) 107384247
KMR: 108238671(mmp14) 108245890
AOCE: 111577984 111587803
CSEM: 103388226(mmp14) 103396588
POV: 109640512 109641241
LCF: 108883931 108903045
SDU: 111223843 111235670
HCQ: 109508489 109512811
BPEC: 110170349 110172013
MALB: 109962674 109974431
SASA: 106569443 106577791 106600280 106608848
OTW: 112214636 112226707 112235598 112260764
SALP: 111953232 111956641 111979299 112080231
ELS: 105020567 105021572
SFM: 108930930 108937864(mmp14) 114911942
PKI: 111837704 111854546
LCM: 102355301(MMP14)
BFO: BRAFLDRAFT_110778 BRAFLDRAFT_121872 BRAFLDRAFT_121873 BRAFLDRAFT_174415 BRAFLDRAFT_230518 BRAFLDRAFT_264495 BRAFLDRAFT_67465 BRAFLDRAFT_89756 BRAFLDRAFT_92283 BRAFLDRAFT_92284
CIN: 100181633
APLC: 110981585 110981864 110982266 110986275 110986300 110986843 110986844 110986855 110986884 110990105
SKO: 100366845 100369238 100369384 100373845 100377895 100378191 102807864
DME: Dmel_CG4859(Mmp1) Dmel_CG7056(HHEX)
DER: 6548508
DSE: Dsec_GM11800
DSI: Dsimw501_GD24926(Dsim_GD24926)
DYA: Dyak_GE11424
DPO: Dpse_GA18484
DPE: 6592953
DAN: Dana_GF11910
DWI: 6640267
DGR: Dgri_GH21566
DMO: Dmoj_GI19538
DAZ: 108616549
DNV: 108654324
DHE: 111593840
DVI: Dvir_GJ21109
MDE: 101888990
LCQ: 111679245
AGA: AgaP_AGAP006904
AAG: 5566822
CQU: CpipJ_CPIJ010856
BIM: 100741313
BTER: 100647268
SOC: 105198300 105205971
MPHA: 105835181 105835693
AEC: 105151121
ACEP: 105619997
PBAR: 105422417 105424383 105426446
VEM: 105560059 105566274
HST: 105190364
DQU: 106744935
CFO: 105255413
LHU: 105675698
PGC: 109858212 109861586 109861889 109861992 109862219 109863338
OBO: 105286124
PCF: 106788603
NVI: 100113893(Mmp1)
MDL: 103577460
TCA: 103313084 103313085 657261(Mmp-1)
DPA: 109542402
NVL: 108563139 108563140 108566081
BMOR: 100144547(Mmp1)
DPL: KGM_204463
PMAC: 106712426
PRAP: 111002882 111003136
HAW: 110371693
TNL: 113492652 113506193
PXY: 105396373
API: 100164006
DNX: 107162516 107166270 107166271
AGS: 114124803 114124805
BTAB: 109040286
CLEC: 106669616 106669674
PHU: Phum_PHUM302710
ZNE: 110834801 110834804 110834807 110840851
FCD: 110860548 110860649 110860650 110860652 110860657
DPX: DAPPUDRAFT_229419 DAPPUDRAFT_303785 DAPPUDRAFT_316218 DAPPUDRAFT_325672 DAPPUDRAFT_325673 DAPPUDRAFT_48702 DAPPUDRAFT_65034
ISC: IscW_ISCW006136
TUT: 107367240
DPTE: 113799701
HRO: HELRODRAFT_108214 HELRODRAFT_108967 HELRODRAFT_110065 HELRODRAFT_189644 HELRODRAFT_193602 HELRODRAFT_193603 HELRODRAFT_69428
LGI: LOTGIDRAFT_158923 LOTGIDRAFT_160600 LOTGIDRAFT_200320 LOTGIDRAFT_231475
PCAN: 112555453 112562988
CRG: 105319539 105333479 105338896
MYI: 110455345 110459519 110462871
OBI: 106869299 106873152 106876107 106879964
LAK: 106152579 106152606 106155462 106156796 106163428 106164145 106168179
NVE: NEMVE_v1g166550
EPA: 110231292 110233809 110238012 110238646 110239804 110251669
ADF: 107349768 107349780
PDAM: 113669026 113674030 113674031 113674901 113678590 113679792 113684651 113684653
SPIS: 111324455 111324941 111324943 111324944 111324945 111324955 111324968 111342087
 » show all
Taxonomy
Reference
1  [PMID:11532942]
  Authors
Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.
  Title
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
  Journal
EMBO J 20:4782-93 (2001)
DOI:10.1093/emboj/20.17.4782
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.80
IUBMB Enzyme Nomenclature: 3.4.24.80
ExPASy - ENZYME nomenclature database: 3.4.24.80
BRENDA, the Enzyme Database: 3.4.24.80
CAS: 161384-17-4

  All links  
Gene (6040)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (347)   
   KEGG MGENES (237)   
   RefGene (5455)   
Protein sequence (78)   
   UniProt (10)   
   SWISS-PROT (7)   
   RefSeq(pep) (19)   
   PDBSTR (31)   
   PMD (11)   
DNA sequence (27)   
   RefSeq(nuc) (22)   
   GenBank (4)   
   EMBL (1)   
3D Structure (10)   
   PDB (10)   
All databases (6155)   

Download RDF
DBGET integrated database retrieval system