EC                Enzyme                                 

membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14
Acting on peptide bonds (peptidases);
BRITE hierarchy
Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain
In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.
EC created 2003
K07763  matrix metalloproteinase-14 (membrane-inserted)
HSA: 4323(MMP14)
PTR: 742887(MMP14)
PPS: 100990208(MMP14)
GGO: 101142469(MMP14)
PON: 100171646(MMP14)
NLE: 100606407(MMP14)
MCC: 712429(MMP14)
MCF: 102132205(MMP14)
CSAB: 103231446(MMP14)
RRO: 104674133(MMP14)
RBB: 108523596(MMP14)
CJC: 100389088(MMP14)
SBQ: 101041075(MMP14)
MMU: 17387(Mmp14)
MCAL: 110309210(Mmp14)
MPAH: 110325048(Mmp14)
RNO: 81707(Mmp14)
MUN: 110550039(Mmp14)
CGE: 100689336(Mmp14)
NGI: 103739479(Mmp14)
HGL: 101723795(Mmp14)
CCAN: 109685808(Mmp14) 109689717
OCU: 100009598(MMP14)
TUP: 102468813(MMP14)
CFA: 403823(MMP14)
VVP: 112926491(MMP14)
AML: 100468621(MMP14)
UMR: 103681059(MMP14)
UAH: 113246072(MMP14)
ORO: 101369821(MMP14)
FCA: 101089776(MMP14)
PTG: 102953674(MMP14)
AJU: 106988210(MMP14)
BTA: 281915(MMP14)
BOM: 102281987(MMP14)
BIU: 109564819(MMP14)
BBUB: 102413520(MMP14)
PHD: 102321416(MMP14)
CHX: 100861171(MMP14)
OAS: 443116(MMP14)
SSC: 397471(MMP14)
CFR: 102513570 102524386(MMP14)
CDK: 105096970(MMP14)
BACU: 103003307(MMP14)
LVE: 103081188(MMP14)
OOR: 101284790(MMP14)
DLE: 111164185(MMP14)
PCAD: 102987825(MMP14)
ECB: 100034170(MMP14)
EPZ: 103556751(MMP14)
EAI: 106840662(MMP14)
MYB: 102240202(MMP14)
MYD: 102761559(MMP14)
MNA: 107531691(MMP14)
HAI: 109393698(MMP14)
RSS: 109458321(MMP14)
DRO: 112301504(MMP14)
PALE: 102887003(MMP14)
RAY: 107498042(MMP14)
LAV: 100671131(MMP14)
TMU: 101345768
MDO: 100030382(MMP14)
SHR: 100932143(MMP14)
PCW: 110223023(MMP14)
OAA: 100091029(MMP14)
CJO: 107307506
LSR: 110481924
PHI: 102107021(MMP14)
ASN: 102368749(MMP14)
AMJ: 102558609(MMP14)
CMY: 102943947
CPIC: 101945719(MMP14)
ACS: 100553534(mmp14)
PVT: 110087815(MMP14)
PBI: 103064383(MMP14)
PMUR: 107295092(MMP14)
GJA: 107109121(MMP14)
XLA: 108707025 407753(mmp14.L)
XTR: 594950(mmp14)
NPR: 108786770(MMP14)
DRE: 373882(mmp14a) 566945(mmp14b)
AMEX: 103024760(mmp14) 103041213
EEE: 113578328 113589197(mmp14)
OLA: 100125428(mmp14) 101171699
NFU: 107377284(mmp14) 107384247
KMR: 108238671(mmp14) 108245890
CSEM: 103388226(mmp14) 103396588
LCM: 102355301(MMP14)
CIN: 100181633
DME: Dmel_CG4859(Mmp1) Dmel_CG7056(HHEX)
DER: 6548508
DSI: Dsimw501_GD24926(Dsim_GD24926)
DPE: 6592953
DWI: 6640267
DAZ: 108616549
DNV: 108654324
DHE: 111593840
MDE: 101888990
LCQ: 111679245
AAG: 5566822
BIM: 100741313
BTER: 100647268
AEC: 105151121
ACEP: 105619997
HST: 105190364
DQU: 106744935
CFO: 105255413
LHU: 105675698
OBO: 105286124
PCF: 106788603
NVI: 100113893(Mmp1)
MDL: 103577460
DPA: 109542402
BMOR: 100144547(Mmp1)
PMAC: 106712426
HAW: 110371693
PXY: 105396373
API: 100164006
BTAB: 109040286
TUT: 107367240
DPTE: 113799701
 » show all
1  [PMID:11532942]
Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.
EMBO J 20:4782-93 (2001)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 161384-17-4

DBGET integrated database retrieval system