KEGG ENZYME: 3.4.24.80

ENZYME: 3.4.24.80

Entry

EC 3.4.24.80 Enzyme

Name

membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain

Comment

In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.

History

EC 3.4.24.80 created 2003

Orthology

K07763

matrix metalloproteinase-14 (membrane-inserted)

Genes

HSA:	4323(MMP14)

PTR:	742887(MMP14)

PPS:	100990208(MMP14)

GGO:	101142469(MMP14)

PON:	100171646(MMP14)

NLE:	100606407(MMP14)

MCC:	712429(MMP14)

MCF:	102132205(MMP14)

CSAB:

103231446(MMP14)

RRO:	104674133(MMP14)

RBB:	108523596(MMP14)

CJC:	100389088(MMP14)

SBQ:	101041075(MMP14)

MMU:	17387(Mmp14)

RNO:	81707(Mmp14)

CGE:	100689336(Mmp14)

NGI:	103739479(Mmp14)

HGL:	101723795(Mmp14)

CCAN:

109685808(Mmp14) 109689717

OCU:	100009598(MMP14)

TUP:	102468813(MMP14)

CFA:	403823(MMP14)

AML:	100468621(MMP14)

UMR:	103681059(MMP14)

ORO:	101369821(MMP14)

FCA:	101089776(MMP14)

PTG:	102953674(MMP14)

AJU:	106988210(MMP14)

BTA:	281915(MMP14)

BOM:	102281987(MMP14)

BIU:	109564819(MMP14)

PHD:	102321416(MMP14)

CHX:	100861171(MMP14)

OAS:	443116(MMP14)

SSC:	397471(MMP14)

CFR:	102513570 102524386(MMP14)

CDK:	105096970(MMP14)

BACU:

103003307(MMP14)

LVE:	103081188(MMP14)

OOR:	101284790(MMP14)

ECB:	100034170(MMP14)

EPZ:	103556751(MMP14)

EAI:	106840662(MMP14)

MYB:	102240202(MMP14)

MYD:	102761559(MMP14)

HAI:	109393698(MMP14)

RSS:	109458321(MMP14)

PALE:

102887003(MMP14)

LAV:	100671131(MMP14)

TMU:

101345768

MDO:	100030382(MMP14)

SHR:	100932143(MMP14)

OAA:	100091029(MMP14)

CJO:

107307506

PHI:	102107021(MMP14)

ASN:	102368749(MMP14)

AMJ:	102558609(MMP14)

CMY:

102943947

CPIC:

101945719(MMP14)

ACS:	100553534(mmp14)

PVT:	110087815(MMP14)

PBI:	103064383(MMP14)

GJA:	107109121(MMP14)

XLA:	108707025 407753(mmp14.L)

XTR:	594950(mmp14)

NPR:	108786770(MMP14)

DRE:	373882(mmp14a) 566945(mmp14b)

SRX:	107706348 107734796 107738136 107753930

SANH:

107668983 107669100 107683283 107691938 107704286

SGH:	107557973 107562471(mmp14) 107588203 107591383

CCAR:

109060080 109064679 109111707 109111713

IPU:	108267723 108267832 108267934(mmp14)

AMEX:

103024760(mmp14) 103041213

TRU:	101061607 101073560(mmp14)

TNG:	GSTEN00000363G001 GSTEN00015140G001 GSTEN00025878G001

LCO:	104927972 104932902(mmp14)

NCC:	104952609 104952619 104956583

MZE:	101464934 101486213

OLA:	100125428(mmp14) 101171699

XMA:	102236291 102236856

PRET:

103475992 103478877

NFU:	107377284(mmp14) 107384247

CSEM:

103388226(mmp14) 103396588

LCF:	108883931 108903045

HCQ:	109508489 109512811

BPEC:

110170349 110172013

SASA:

106569443 106577791 106600280 106608848

ELS:	105020567 105021572

SFM:	108930930 108937864

LCM:	102355301(MMP14)

BFO:	BRAFLDRAFT_110778 BRAFLDRAFT_121872 BRAFLDRAFT_121873 BRAFLDRAFT_174415 BRAFLDRAFT_230518 BRAFLDRAFT_264495 BRAFLDRAFT_67465 BRAFLDRAFT_89756 BRAFLDRAFT_92283 BRAFLDRAFT_92284

CIN:

100181633

APLC:

110981585 110981864 110982266 110986275 110986300 110986843 110986844 110986855 110986884 110990105

SKO:	100366845 100369238 100369384 100373845 100377895 100378191 102807864

DME:	Dmel_CG4859(Mmp1) Dmel_CG7056(HHEX)

DPO:	Dpse_GA18484

DAN:	Dana_GF11910

DER:	Dere_GG19900

DPE:	Dper_GL17167

DSE:	Dsec_GM11800

DSI:	Dsimw501_GD24926(Dsim_GD24926)

DWI:	Dwil_GK21871

DYA:	Dyak_GE11424

DGR:	Dgri_GH21566

DMO:	Dmoj_GI19538

DVI:	Dvir_GJ21109

MDE:

101888990

AGA:	AgaP_AGAP006904

AAG:

5566822

CQU:	CpipJ_CPIJ010856

BIM:

100741313

BTER:

100647268

SOC:	105198300 105205971

AEC:

105151121

ACEP:

105619997

PBAR:

105422417 105424383 105426446

HST:

105190364

CFO:

105255413

LHU:

105675698

PGC:	109858212 109861586 109861889 109861992 109862219 109863338

NVI:	100113893(Mmp1)

TCA:	103313084 103313085 657261(Mmp-1)

DPA:

109542402

NVL:	108563139 108563140 108566081

BMOR:

100144547(Mmp1)

DPL:	KGM_204463

PMAC:

PRAP:

PXY:

API:

DNX:	107162516 107166270 107166271

PHU:	Phum_PHUM302710

ZNE:	110834801 110834804 110834807 110840851

FCD:	110860548 110860649 110860650 110860652 110860657

DPX:	DAPPUDRAFT_229419 DAPPUDRAFT_303785 DAPPUDRAFT_316218 DAPPUDRAFT_325672 DAPPUDRAFT_325673 DAPPUDRAFT_48702 DAPPUDRAFT_65034

ISC:	IscW_ISCW006136

TUT:

107367240

HRO:	HELRODRAFT_108214 HELRODRAFT_108967 HELRODRAFT_110065 HELRODRAFT_189644 HELRODRAFT_193602 HELRODRAFT_193603 HELRODRAFT_69428

LGI:	LOTGIDRAFT_158923 LOTGIDRAFT_160600 LOTGIDRAFT_200320 LOTGIDRAFT_231475

CRG:	105319539 105333479 105338896

MYI:	110455345 110459519 110462871

OBI:	106867838 106869299 106873152 106876107 106879964

LAK:	106152579 106152606 106155462 106156796 106163428 106164145 106168168 106168179

NVE:	NEMVE_v1g166550

EPA:	110231292 110233809 110238012 110238646 110239804 110251669

ADF:	107349768 107349780

» show all

Reference

1 [PMID:11532942]

Authors

Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.

Title

Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.

Journal

EMBO J 20:4782-93 (2001)
DOI:10.1093/emboj/20.17.4782

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.80

IUBMB Enzyme Nomenclature:

3.4.24.80

ExPASy - ENZYME nomenclature database:

3.4.24.80

BRENDA, the Enzyme Database:

3.4.24.80

CAS:	161384-17-4

DBGET integrated database retrieval system