KEGG   ENZYME: 3.4.24.81Help
Entry
EC 3.4.24.81                Enzyme                                 

Name
ADAM10 endopeptidase;
Kuzbanian protein;
myelin-associated disintegrin metalloproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase of broad specificity
Comment
In peptidase family M12. Partially responsible for the "alpha-secretase" activity in brain that degrades the potentially harmful beta-amyloid peptide. Work with ADAM10-deficient mice supports a role in Notch signalling.
History
EC 3.4.24.81 created 2003
Orthology
K06704  disintegrin and metalloproteinase domain-containing protein 10
Genes
HSA: 102(ADAM10)
PTR: 746942(ADAM10)
PPS: 100979438(ADAM10)
GGO: 101142970(ADAM10)
PON: 100169741(ADAM10)
NLE: 100606667(ADAM10)
MCC: 701355(ADAM10)
MCF: 101925715(ADAM10)
CSAB: 103245557(ADAM10)
RRO: 104670896(ADAM10)
RBB: 108544959(ADAM10)
CJC: 100415138(ADAM10)
SBQ: 101041855(ADAM10)
MMU: 11487(Adam10)
RNO: 29650(Adam10)
CGE: 100772891(Adam10)
NGI: 103737147(Adam10)
HGL: 101698280(Adam10)
OCU: 100101614(ADAM10)
TUP: 102467957(ADAM10)
CFA: 478321(ADAM10)
AML: 100476350(ADAM10)
UMR: 103676794(ADAM10)
ORO: 101380324(ADAM10)
FCA: 101087998(ADAM10)
PTG: 102950285(ADAM10)
AJU: 106973789(ADAM10)
BTA: 282132(ADAM10)
BOM: 102285401(ADAM10)
BIU: 109564357(ADAM10)
PHD: 102324691(ADAM10)
CHX: 102172903(ADAM10)
OAS: 101116733(ADAM10)
SSC: 397345(ADAM10)
CFR: 102518129(ADAM10)
CDK: 105088967(ADAM10)
BACU: 103011557(ADAM10)
LVE: 103071850(ADAM10)
OOR: 101275940(ADAM10)
ECB: 100068314(ADAM10)
EPZ: 103552041(ADAM10)
EAI: 106830043(ADAM10)
MYB: 102260183(ADAM10)
MYD: 102754258(ADAM10)
HAI: 109390694(ADAM10)
RSS: 109447663(ADAM10)
PALE: 102895434(ADAM10)
LAV: 100659084(ADAM10)
TMU: 101350043
MDO: 100024929 100027329(ADAM10)
SHR: 100913194(ADAM10) 100925760
OAA: 100074755(ADAM10)
GGA: 374113(ADAM10)
MGP: 100545069
CJO: 107318510(ADAM10)
APLA: 101794215(ADAM10)
ACYG: 106033621(ADAM10)
TGU: 100219653(ADAM10)
GFR: 102043060(ADAM10)
FAB: 101811782(ADAM10)
PHI: 102110765(ADAM10)
PMAJ: 107209233(ADAM10)
CCAE: 111933890(ADAM10) 111945310
CCW: 104684038(ADAM10)
FPG: 101910860(ADAM10)
FCH: 102050786(ADAM10)
CLV: 102083444(ADAM10)
EGZ: 104130770(ADAM10)
AAM: 106496382(ADAM10)
AMJ: 102562482 102563250(ADAM10)
PSS: 102444574(ADAM10) 102461827
CMY: 102936468 102944138(ADAM10)
ACS: 100553674(adam10)
PVT: 110074537(ADAM10) 110079237
PBI: 103053091 103062263(ADAM10)
GJA: 107107516(ADAM10)
XLA: 108706832 108711361 399187(adam10.S)
XTR: 100491788 733451(adam10)
NPR: 108789826(ADAM10) 108796952
DRE: 393392(adam10b) 560975(si:ch1073-396h14.1) 566044(adam10a)
IPU: 108259300(adam10) 108271130 108275251(ADAM10)
NCC: 104960057(adam10) 104960084
OTW: 112252197 112263716(adam10)
LCM: 102349523 102351415(ADAM10)
CMK: 103183500 103189371(adam10)
CIN: 100184040
DME: Dmel_CG1964(Kul) Dmel_CG7147(kuz)
DSI: Dsimw501_GD15481(Dsim_GD15481) Dsimw501_GD21457(Dsim_GD21457)
CEL: CELE_DY3.7(sup-17)
CBR: CBG12369(Cbr-sup-17)
BMY: Bm1_55800
TSP: Tsp_11370
OBI: 106879111
SHX: MS3_02880
 » show all
Taxonomy
Reference
1  [PMID:12475894]
  Authors
Gutwein P, Mechtersheimer S, Riedle S, Stoeck A, Gast D, Joumaa S, Zentgraf H, Fogel M, Altevogt DP.
  Title
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
  Journal
FASEB J 17:292-4 (2003)
DOI:10.1096/fj.02-0430fje
  Sequence
[hsa:102]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.81
IUBMB Enzyme Nomenclature: 3.4.24.81
ExPASy - ENZYME nomenclature database: 3.4.24.81
BRENDA, the Enzyme Database: 3.4.24.81
CAS: 193099-09-1

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