KEGG   ENZYME: 3.5.1.104Help
Entry
EC 3.5.1.104                Enzyme                                 

Name
peptidoglycan-N-acetylglucosamine deacetylase;
HP310;
PgdA;
SpPgdA;
BC1960;
peptidoglycan deacetylase;
N-acetylglucosamine deacetylase;
peptidoglycan GlcNAc deacetylase;
peptidoglycan N-acetylglucosamine deacetylase;
PG N-deacetylase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
peptidoglycan-N-acetylglucosamine amidohydrolase
Reaction(IUBMB)
peptidoglycan-N-acetyl-D-glucosamine + H2O = peptidoglycan-D-glucosamine + acetate [RN:R09721]
Reaction(KEGG)
Substrate
peptidoglycan-N-acetyl-D-glucosamine;
H2O [CPD:C00001]
Product
peptidoglycan-D-glucosamine [CPD:C19842];
acetate [CPD:C00033]
Comment
Modification of peptidoglycan by N-deacetylation is an important factor in virulence of Helicobacter pylori, Listeria monocytogenes and Streptococcus suis [4-6]. The enzyme from Streptococcus pneumoniae is a metalloenzyme using a His-His-Asp zinc-binding triad with a nearby aspartic acid and histidine acting as the catalytic base and acid, respectively [3].
History
EC 3.5.1.104 created 2010
Orthology
K22278  peptidoglycan-N-acetylglucosamine deacetylase
Genes
PHD: 102342280
ABE: ARB_03699
TVE: TRV_05797
BSC: COCSADRAFT_340659
BOR: COCMIDRAFT_98371
KPK: A593_01855
KVQ: SP68_06010
KOX: KOX_24505
KOY: J415_13095
KQV: B8P98_09805
YPE: YPO1573
YPK: y2591
YPA: YPA_0869
YPN: YPN_2407
YPM: YP_1461(cDA11)
YPZ: YPZ3_1436
YPD: YPD4_1401
YPX: YPD8_1545
YPW: CH59_259
YPJ: CH55_965
YPV: BZ15_1979
YPL: CH46_3553
YPS: YPTB1582
YPO: BZ17_930
YPY: YPK_2502
YPB: YPTS_1696
YPQ: DJ40_629
YPU: BZ21_922
YPR: BZ20_381
YPC: BZ23_1201
YPF: BZ19_1022
RAA: Q7S_09605
EBI: EbC_10660
PAM: PANA_1934
PAJ: PAJ_1268
XBO: XBJ1_0156
LEZ: GLE_1877
LEM: LEN_3101
DKO: I596_1132
PPT: PPS_3390
PPX: T1E_2036
PSB: Psyr_3937
PFL: PFL_1362
PPRO: PPC_1416
PFB: VO64_4201
PSOS: POS17_1382
PANR: A7J50_1080
SWD: Swoo_4312
SPSW: Sps_05271
CPS: CPS_5017
MAD: HP15_3542
SALH: HMF8227_01179(pdaA)
LHA: LHA_3256
HAM: HALO0426
SLIM: SCL_1713
BPC: BPTD_2081
BPER: BN118_1403
BPET: B1917_1894
BPEU: Q425_29330
BPA: BPP1417
BBR: BB2486
TEA: KUI_0965
TEG: KUK_1293
TAS: TASI_1011
TAT: KUM_0441
VEI: Veis_0999
DAC: Daci_2092
HPY: HP0310
HPJ: jhp_0295
HPG: HPG27_289
HPL: HPB8_1252
HPZ: HPKB_0321
HPD: KHP_0307
HEY: MWE_0391
HPYR: K747_10225
HPYI: K750_03130
HPYU: K751_05890
HPYM: K749_04095
HEB: U063_0650
HEZ: U064_0651
HAC: Hac_1018
SULR: B649_04430
CCQ: N149_1147
CCF: YSQ_02950
CCY: YSS_06480
CCOI: YSU_02985
CCOF: VC76_05935(pgdA)
CCOO: ATE51_01194(pgdA)
CCUN: CCUN_1447
DVU: DVU0275
DVL: Dvul_2705
DVM: DvMF_1579
DDS: Ddes_0123
BBA: Bd0468
BBAT: Bdt_0458
BBW: BDW_06420
BBAC: EP01_14245
BMX: BMS_1010
ARA: Arad_7513
AVI: Avi_5882
RLE: pRL120140
SHZ: shn_27835
BRS: S23_20050
SNO: Snov_4262
META: Y590_10160
MAQU: Maq22A_c14965(cda1)
RVA: Rvan_2148
RSP: RSP_1415
JAN: Jann_2517
NAR: Saro_1595
SPHD: HY78_10065
SPHM: G432_01060
SPHI: TS85_23625
BSU: BSU12100(yjeA)
BSR: I33_1361
BSL: A7A1_0041
BSH: BSU6051_12100(yjeA)
BSUT: BSUB_01318(pdaC)
BSUL: BSUA_01318(pdaC)
BSUS: Q433_06890
BSS: BSUW23_06155(yjeA)
BST: GYO_1515
BSO: BSNT_07678(yjeA)
BSQ: B657_12100(yjeA)
BLI: BL00501(yjeA)
BLD: BLi00655(yjeA)
BLH: BaLi_c07440(yjeA)
BAQ: BACAU_2414(nodB)
BYA: BANAU_2553(nodB)
BAMP: B938_12405
BAML: BAM5036_2323(nodB)
BAMA: RBAU_2537(nodB)
BAMN: BASU_2326(nodB)
BAMB: BAPNAU_1177(nodB)
BAMT: AJ82_13565
BAMY: V529_26770
BMP: NG74_02507(pdaC_1)
BAO: BAMF_2469(RBAM_024010)
BQL: LL3_02768
BQY: MUS_2868(nodB)
BAMI: KSO_007375
BAMC: U471_24850
BAMF: U722_13030
BHA: BH1917(notB)
BANV: DJ46_2392(pdaB) DJ46_769
BCQ: BCQ_1952(pdaA) BCQ_3410
BTL: BALH_1738(pdaA) BALH_3254
BTW: BF38_3178 BF38_4794(pdaB)
BWW: bwei_1339(pdaB) bwei_3053(pdaA)
BMYO: BG05_2413(pdaB) BG05_4020
BJS: MY9_1322
BACP: SB24_16730
BACB: OY17_15265
BACO: OXB_3234
BACY: QF06_05035
BACL: BS34A_13410(pdaA_2)
BALM: BsLM_1270
BEO: BEH_02530
BGY: BGLY_0684
BKW: BkAM31D_12670(pgdA_1) BkAM31D_23815(pgdA_3)
BBEV: BBEV_2265(pdaA)
OIH: OB2101
GTN: GTNG_1776
AFL: Aflv_1209
AAMY: GFC30_1659
VPN: A21D_00590(pgdA_1) A21D_01605(pgdA_2)
BSE: Bsel_2666
LMO: lmo0415
LMOC: LMOSLCC5850_0417(pgdA)
LMOE: BN418_0474
LMOB: BN419_0482
LMOD: LMON_0423
LMOW: AX10_10635
LMOM: IJ09_08250
LMOG: BN389_04420(yjeA)
LMP: MUO_02285
LMOL: LMOL312_0426(pgdA)
LMOX: AX24_14895
LMQ: LMM7_0439(pgdA)
LMS: LMLG_2009
LMW: LMOSLCC2755_0423(pgdA)
LMX: LMOSLCC2372_0418(pgdA)
LMON: LMOSLCC2376_0408(pgdA)
LMOS: LMOSLCC7179_0403(pgdA)
LMOO: LMOSLCC2378_0435(pgdA)
LMOY: LMOSLCC2479_0416(pgdA)
LMOT: LMOSLCC2540_0437(pgdA)
LMOA: LMOATCC19117_0443(pgdA)
LMOK: CQ02_02265
LIN: lin0436
LWE: lwe0378
LSG: lse_0373
LIV: LIV_0347
EAN: Eab7_0470
PPO: PPM_1167(pdaC) PPM_2575(pdaA) PPM_2966(M1_3310)
ASOC: CB4_00017(pdaC_1) CB4_02612(pgdA_3) CB4_02888(pdaC_2) CB4_03386(pgdA_4) CB4_03640(pgdA_5)
LLK: LLKF_1369(pda)
LLS: lilo_1252
LLM: llmg_1168
LLW: kw2_1261
LLJ: LG36_1097(pda)
LGR: LCGT_1502
LGV: LCGL_1524
SPY: SPy_1370
SPYA: A20_1152c(deadD)
SPM: spyM18_1382(deadD2)
SPS: SPs0816
SPF: SpyM50742
SPYH: L897_05575
SPN: SP_1479(pgdA)
SPD: SPD_1309(pgdA)
SPR: spr1333(pgdA)
SPW: SPCG_1467(pgdA)
SJJ: SPJ_1378
SPX: SPG_1406(pgdA)
SNT: SPT_0797
SND: MYY_0814
SPNN: T308_03650
SPV: SPH_1594
SPP: SPP_1500
SNP: SPAP_1506
SAG: SAG0824
SAN: gbs0842
SAK: SAK_0948
SGC: A964_0827
SAGM: BSA_9120
SAGI: MSA_9680
SAGR: SAIL_9690
SAGP: V193_03900
SAGC: DN94_03900
SAGE: EN72_04855
SAGG: EN73_04555
SAGN: W903_0915
SSA: SSA_0963
SSB: SSUBM407_1524(pgdA)
SSI: SSU1448(pgdA)
SSS: SSUSC84_1477(pgdA)
SSF: SSUA7_1467(pgdA)
SUP: YYK_06910
SSUY: YB51_7305
SSK: SSUD12_1592(pgdA)
SUI: SSUJS14_1605(pgdA)
SUO: SSU12_1582(pgdA)
SRP: SSUST1_1514(pgdA)
SSUT: TL13_1436(pgdA)
SGO: SGO_0948(pgdA)
SEZ: Sez_0670
SEQ: SZO_13280
SEQU: Q426_05970
SEU: SEQ_0697
SUB: SUB1219
SDS: SDEG_1418
SDA: GGS_1292
SDC: SDSE_1461
SMB: smi_1399(pgdA)
SOR: SOR_1343(pgdA)
STK: STP_1052
SCF: Spaf_0817
SIE: SCIM_0987
SIB: SIR_0630
SIU: SII_0600
SANG: SAIN_0724
SANC: SANR_0736
SANS: DK43_06480
SIK: K710_0654
STRN: SNAG_1322(pgdA)
LSA: LCA_1812
LBR: LVIS_2270
LBH: Lbuc_0237
EFA: EF0590
EFL: EF62_0980
EFQ: DR75_2563
EFM: M7W_931
CRN: CAR_c10900(pdaA)
JDA: BW727_100805(pdaC) BW727_100955(pdaA)
CKL: CKL_1534
CKR: CKR_1425
AMT: Amet_4252
HSC: HVS_16385(pgdA3)
CCE: Ccel_2251
RUM: CK1_13420
RIX: RO1_21380
CCT: CC1_32590
ROB: CK5_13130
RTO: RTO_17800
CPY: Cphy_3069
CSO: CLS_04020
BPRL: CL2_20770
CPRO: CPRO_27370(pdaC)
PDC: CDIF630_02852(pgdA2)
SWO: Swol_1069
DSY: DSY4156
DHD: Dhaf_1185
DRM: Dred_3051
EHL: EHLA_1987
CTHM: CFE_2619
TTE: TTE0866(Cda1)
TKI: TKV_c08850(pdaC)
CHY: CHY_1849
TTM: Tthe_1972
AIN: Acin_0824
ERH: ERH_0918
CEF: CE2356
CDI: DIP0225
CSP: WM42_1422
CGV: CGLAU_06790(pgdA)
CAMG: CAMM_09340
CMIN: NCTC10288_02522(pdaA)
SCO: SCO0936(SCM10.24c) SCO3712(SCH35.12c) SCO6178(SC6C5.14c)
SBH: SBI_06610
SALS: SLNWT_3265
SRW: TUE45_00167(pgdA_1) TUE45_00539(pgdA_3) TUE45_06808(pgdA_6)
SLE: sle_07130(sle_07130) sle_15000(sle_15000)
SRN: A4G23_05220(pgdA_3)
SLX: SLAV_06235(pgdA1) SLAV_14450(pgdA4) SLAV_39685(pgdA6)
CMI: CMM_1145
CMS: CMS1469
CMC: CMN_01115
ARR: ARUE_c40890(yjeA)
ARM: ART_2970
AAU: AAur_3949
IDO: I598_2372(pdaC)
CGRN: 4412665_00608(xynD)
ACIJ: JS278_02679(pdaC)
NDK: I601_2591(pgdA)
KFL: Kfla_5572
TFU: Tfu_1621
NDA: Ndas_1932
TCU: Tcur_4717
SRO: Sros_7981
GOB: Gobs_2326
MMAR: MODMU_5284
AMN: RAM_22990
AMM: AMES_4459
AMZ: B737_4459
SAQ: Sare_2229
ACTN: L083_3692(nodB)
BTP: D805_0236
BCOR: BCOR_0199
BANG: BBAG_0362
RXY: Rxyl_2742
AMR: AM1_4377
TER: Tery_2798
GLJ: GKIL_1251 GKIL_1403(kgd)
NAZ: Aazo_0652
NSP: BMF81_02030(pgdA)
DMG: GY50_0974
CAG: Cagg_1551
STI: Sthe_2997
AMU: Amuc_1500
AGL: PYTT_0264
FMR: Fuma_01617(pdaA)
ACA: ACP_1974
ABAS: ACPOL_1616
ABAC: LuPra_05273(pdaA)
EPO: Epro_0046(pgaB)
TLI: Tlie_1631
SBR: SY1_21880
EAO: BD94_2396
ELB: VO54_00337(pgdA)
CABY: Cabys_2329(pgdA_CDA1)
NJA: NSJP_4052(nodB)
SAAL: L336_1027
TVO: TVG0526731(TVG0526731)
HVO: HVO_A0301
HTU: Htur_0030
 » show all
Taxonomy
Reference
1  [PMID:15961396]
  Authors
Psylinakis E, Boneca IG, Mavromatis K, Deli A, Hayhurst E, Foster SJ, Varum KM, Bouriotis V
  Title
Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis.
  Journal
J Biol Chem 280:30856-63 (2005)
DOI:10.1074/jbc.M407426200
  Sequence
Reference
2  [PMID:18323609]
  Authors
Tsalafouta A, Psylinakis E, Kapetaniou EG, Kotsifaki D, Deli A, Roidis A, Bouriotis V, Kokkinidis M
  Title
Purification, crystallization and preliminary X-ray analysis of the peptidoglycan N-acetylglucosamine deacetylase BC1960 from Bacillus cereus in the presence of its substrate (GlcNAc)6.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 64:203-5 (2008)
DOI:10.1107/S1744309108002510
  Sequence
[bce:BC1960]
Reference
3  [PMID:16221761]
  Authors
Blair DE, Schuttelkopf AW, MacRae JI, van Aalten DM
  Title
Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor.
  Journal
Proc Natl Acad Sci U S A 102:15429-34 (2005)
DOI:10.1073/pnas.0504339102
  Sequence
[spr:spr1333]
Reference
4  [PMID:19147492]
  Authors
Wang G, Olczak A, Forsberg LS, Maier RJ
  Title
Oxidative stress-induced peptidoglycan deacetylase in Helicobacter pylori.
  Journal
J Biol Chem 284:6790-800 (2009)
DOI:10.1074/jbc.M808071200
  Sequence
[hpy:HP0310]
Reference
5  [PMID:19809250]
  Authors
Popowska M, Kusio M, Szymanska P, Markiewicz Z
  Title
Inactivation of the wall-associated de-N-acetylase (PgdA) of Listeria monocytogenes results in greater susceptibility of the cells to induced autolysis.
  Journal
J Microbiol Biotechnol 19:932-45 (2009)
  Sequence
[lmo:lmo0415]
Reference
6  [PMID:18990186]
  Authors
Fittipaldi N, Sekizaki T, Takamatsu D, de la Cruz Dominguez-Punaro M, Harel J, Bui NK, Vollmer W, Gottschalk M
  Title
Significant contribution of the pgdA gene to the virulence of Streptococcus suis.
  Journal
Mol Microbiol 70:1120-35 (2008)
DOI:10.1111/j.1365-2958.2008.06463.x
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.104
IUBMB Enzyme Nomenclature: 3.5.1.104
ExPASy - ENZYME nomenclature database: 3.5.1.104
BRENDA, the Enzyme Database: 3.5.1.104

DBGET integrated database retrieval system