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Entry
EC 3.5.1.110                Enzyme                                 

Name
peroxyureidoacrylate/ureidoacrylate amidohydrolase;
RutB
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
(Z)-3-ureidoacrylate peracid amidohydrolase
Reaction(IUBMB)
(1) (Z)-3-ureidoacrylate peracid + H2O = (Z)-3-peroxyaminoacrylate + CO2 + NH3 (overall reaction) [RN:R09948];
(1a) (Z)-3-ureidoacrylate peracid + H2O = (Z)-3-peroxyaminoacrylate + carbamate [RN:R09947];
(1b) carbamate = CO2 + NH3 (spontaneous) [RN:R07316];
(2) (Z)-2-methylureidoacrylate peracid + H2O = (Z)-2-methylperoxyaminoacrylate + CO2 + NH3 (overall reaction) [RN:R09950];
(2a) (Z)-2-methylureidoacrylate peracid + H2O = (Z)-2-methylperoxyaminoacrylate + carbamate [RN:R09949];
(2b) carbamate = CO2 + NH3 (spontaneous)
Reaction(KEGG)
Substrate
(Z)-3-ureidoacrylate peracid [CPD:C20231];
H2O [CPD:C00001];
carbamate [CPD:C01563];
(Z)-2-methylureidoacrylate peracid [CPD:C20232]
Product
(Z)-3-peroxyaminoacrylate [CPD:C20249];
CO2 [CPD:C00011];
NH3 [CPD:C00014];
carbamate [CPD:C01563];
(Z)-2-methylperoxyaminoacrylate [CPD:C20250]
Comment
The enzyme also shows activity towards ureidoacrylate. Part of the Rut pyrimidine catabolic pathway.
History
EC 3.5.1.110 created 2012
Pathway
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K09020  ureidoacrylate peracid hydrolase
Genes
ECO: b1011(rutB)
ECJ: JW5139(ycdL)
ECD: ECDH10B_1083(rutB)
EBW: BWG_0865(rutB)
ECOK: ECMDS42_0856(ycdL)
ECE: Z1510
ECS: ECs1257
ECF: ECH74115_1248
ETW: ECSP_1180
ELX: CDCO157_1202
EOJ: ECO26_1249(ycdL)
EOI: ECO111_1200(ycdL)
EOH: ECO103_1057(ycdL)
ECOO: ECRM13514_1188(rutB)
ECOH: ECRM13516_1117(rutB)
ECG: E2348C_1062(rutB)
EOK: G2583_1244(rutB)
ESO: O3O_09365
ESM: O3M_15905
ESL: O3K_15930
ECC: c1148(ycdL)
ECP: ECP_1010
ECI: UTI89_C1074(ycdL)
ECY: ECSE_1073
ECR: ECIAI1_1056(rutB)
ECQ: ECED1_1167(rutB)
ECK: EC55989_1122(rutB)
ECT: ECIAI39_2144(rutB)
EOC: CE10_1089(rutB)
EUM: ECUMN_1194(rutB)
ECZ: ECS88_1027(rutB)
ELO: EC042_1086(rutB)
ESE: ECSF_0917
EBR: ECB_01014(ycdL)
EBD: ECBD_2583
EKF: KO11_17665(rutB)
EAB: ECABU_c10380(rutB)
EDJ: ECDH1ME8569_0965(rutB)
ENA: ECNA114_1082(ycdL)
ELW: ECW_m1121(rutB)
ELL: WFL_05470(rutB)
ELC: i14_1048(ycdL)
ELD: i02_1048(ycdL)
ELP: P12B_c0996(ycdL)
EBL: ECD_01014(rutB)
EBE: B21_01021(rutB)
ELF: LF82_2050(rutB)
ECOI: ECOPMV1_01033(rutB_1)
ECOJ: P423_05495
ECOS: EC958_1208(ycdL)
SFL: SF1014
SFX: S1084
SFV: SFV_1023
SFE: SFxv_1100(rutB)
SFN: SFy_1389
SFS: SFyv_1432
SFT: NCTC1_01053(rutB)
SSN: SSON_1030
ENC: ECL_02623(rutB)
ECLO: ENC_16300
EEC: EcWSU1_01609(rutB)
ECLX: LI66_07885
ECLY: LI62_08675
ECLZ: LI64_08210
ESA: ESA_02363
CSK: ES15_2462(rutB)
CTU: CTU_15920(rutB)
KPN: KPN_01037(ycdL)
KPU: KP1_2025(ycdL)
KPP: A79E_3195
KPT: VK055_1440(rutB)
KPE: KPK_3521
KPR: KPR_3486
KPJ: N559_3249
KPX: PMK1_03377(rutB)
KPNU: LI86_16885
KPNK: BN49_2126(rutB)
KVA: Kvar_3342
KOX: KOX_16995
KOE: A225_2249
EAE: EAE_16030
EAR: CCG30701
KQV: B8P98_18065(rutB)
RAO: DSD31_16100(rutB)
LEI: C2U54_13135(rutB)
LEH: C3F35_03170(rutB)
LNI: CWR52_04070(rutB)
LEW: DAI21_18785(rutB)
EBC: C2U52_26765(rutB)
PSTS: E05_37930
YEN: YE1949
YEY: Y11_13691
YEW: CH47_1381(rutB)
YET: CH48_3373(rutB)
YMA: DA391_09480(rutB)
SPE: Spro_1822
SRL: SOD_c16470(rutB)
SPLY: Q5A_009025(rutB_1)
RAA: Q7S_15220
EBI: EbC_15650(rutB)
EPE: CI789_10750(rutB)
PAM: PANA_4034(ycdL)
PLF: PANA5342_p10176(rutB)
PAJ: PAJ_p0252(ycdL)
PAQ: PAGR_p121
PVA: Pvag_0804(ycdl1)
PAGG: AL522_11300(rutB)
PSTW: DSJ_25270
PGZ: C2E15_07955(rutB)
PCD: C2E16_07860(rutB)
PSB: Psyr_0998
PAMG: BKM19_007700(rutB)
PAVL: BKM03_06645(rutB)
PSA: PST_3598
PSTT: CH92_21420
PSES: PSCI_0303
ACC: BDGL_002278(rutB)
ACI: ACIAD0028
ASJ: AsACE_CH00967(rutB)
ARJ: DOM24_07650(rutB)
AMAL: I607_16320
AMAE: I876_16625
AMAO: I634_16575
AMAD: I636_16510
AMAI: I635_17255
AMAG: I533_16140
AMAC: MASE_16135
GPS: C427_0833
PLG: NCTC10937_03398(rutB)
VPD: VAPA_1c50090(rutB)
VAM: C4F17_21765(rutB)
HOH: Hoch_3936
PLA: Plav_0992
SMD: Smed_3660
ATU: Atu2499
ARA: Arad_7072
ATF: Ach5_23690(rutB)
AGR: AGROH133_08498(rutB)
AGC: BSY240_840(rutB)
ARO: B0909_00435(rutB)
RIR: BN877_I2580(rutB)
BOS: BSY19_3280(rutB)
AZC: AZC_2493
MEX: Mext_1737
MEA: Mex_1p1663(rutB)
MDI: METDI2411(rutB)
MCH: Mchl_2056
MPO: Mpop_1076
MOR: MOC_1963(rutB)
META: Y590_08275
BID: Bind_1386
CCR: CC_2795
CAK: Caul_3979
CSE: Cseg_2078
RDE: RD1_1500
KVU: EIO_2338
KVL: KVU_1873
KRO: BVG79_02010(rutB)
NOV: TQ38_014340(rutB)
SWI: Swit_4275
SPHI: TS85_06045
SSAN: NX02_23380
SPHR: BSY17_3631(rutB)
NCB: C0V82_24840(rutB)
GEA: GARCT_p00014(rutB)
PRI: PRIO_2645
BTS: Btus_2001
RRT: 4535765_03099(rutB)
PSIM: KR76_24890
SEN: SACE_1113
KAL: KALB_1146
STI: Sthe_2711
ABAC: LuPra_02691(rutB_1)
RMR: Rmar_2385
TAA: NMY3_00539(rutB_1) NMY3_01094(rutB_2) NMY3_02609(rutB_3)
 » show all
Taxonomy
Reference
1  [PMID:20400551]
  Authors
Kim KS, Pelton JG, Inwood WB, Andersen U, Kustu S, Wemmer DE
  Title
The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems.
  Journal
J Bacteriol 192:4089-102 (2010)
DOI:10.1128/JB.00201-10
  Sequence
[eco:b1011]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.110
IUBMB Enzyme Nomenclature: 3.5.1.110
ExPASy - ENZYME nomenclature database: 3.5.1.110
BRENDA, the Enzyme Database: 3.5.1.110

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