KEGG   ENZYME: 3.5.1.12Help
Entry
EC 3.5.1.12                 Enzyme                                 

Name
biotinidase;
amidohydrolase biotinidase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
biotin-amide amidohydrolase
Reaction(IUBMB)
biotin amide + H2O = biotin + NH3 [RN:R01076]
Reaction(KEGG)
R01076;
(other) R01077 R06134
Show
Substrate
biotin amide [CPD:C01893];
H2O [CPD:C00001]
Product
biotin [CPD:C00120];
NH3 [CPD:C00014]
Comment
Also acts on biotin esters.
History
EC 3.5.1.12 created 1961
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K01435  biotinidase
Genes
HSA: 686(BTD)
PTR: 470760(BTD)
PPS: 100983934(BTD)
GGO: 101131296(BTD)
PON: 100458389(BTD)
NLE: 100584490(BTD)
MCC: 677722(BTD)
MCF: 101926326(BTD)
CSAB: 103241707(BTD)
RRO: 104656449(BTD)
RBB: 108535861(BTD)
CJC: 100409568(BTD)
SBQ: 101042865(BTD)
MMU: 26363(Btd)
RNO: 306262(Btd)
CGE: 100755324(Btd)
NGI: 103747521(Btd)
HGL: 101716226(Btd)
CCAN: 109694811(Btd)
OCU: 100341187(BTD)
TUP: 102476912(BTD)
CFA: 477059(BTD)
AML: 100483327(BTD)
UMR: 103679387(BTD)
ORO: 101380238(BTD)
FCA: 101094289(BTD)
PTG: 102952175(BTD)
AJU: 106971609(BTD)
BTA: 537669(BTD)
BOM: 102282711(BTD)
BIU: 109561800(BTD)
PHD: 102323994(BTD)
CHX: 102179988(BTD)
OAS: 101113196(BTD)
SSC: 100737057(BTD)
CFR: 102506341(BTD)
CDK: 105096612(BTD)
BACU: 103004341(BTD)
LVE: 103080922(BTD)
OOR: 101278082(BTD)
ECB: 100063800(BTD)
EPZ: 103561484(BTD)
EAI: 106842762(BTD)
MYB: 102258405(BTD)
MYD: 102759604(BTD)
HAI: 109395825(BTD)
RSS: 109444518(BTD)
PALE: 102894216(BTD)
LAV: 100663934(BTD)
TMU: 101354864
MDO: 100030538(BTD)
SHR: 100922840(BTD)
OAA: 100084040(BTD)
GGA: 420639(BTD)
MGP: 100540232(BTD)
CJO: 107309167(BTD)
APLA: 101796688(BTD)
ACYG: 106030251(BTD)
TGU: 100223229 100226458(BTD)
GFR: 102043957(BTD)
FAB: 101821386(BTD)
PHI: 102104565(BTD)
PMAJ: 107199918(BTD)
CCAE: 111923444(BTD)
CCW: 104689076(BTD)
FPG: 101914603(BTD)
FCH: 102056176(BTD)
CLV: 102085390(BTD)
EGZ: 104126131(BTD)
AAM: 106483475(BTD)
AMJ: 102566286(BTD)
PSS: 102458076(BTD)
CMY: 102946514(BTD)
CPIC: 101939105(BTD)
ACS: 100556978(btd)
PVT: 110072153(BTD)
PBI: 103068246(BTD)
GJA: 107126169(BTD)
XLA: 108718912(btd.L)
XTR: 100489727(btd)
NPR: 108803235(BTD)
DRE: 555376(btd)
SRX: 107732456(btd)
SANH: 107694759(btd)
SGH: 107559753
CCAR: 109080426(btd)
IPU: 108256913
AMEX: 103037138
TRU: 101069377(Biotinase)
NCC: 104944686 104944699(btd)
OLA: 101173953
XMA: 102233822(btd)
NFU: 107383317
KMR: 108240453(btd)
CSEM: 103394637(btd)
SDU: 111223068
HCQ: 109527670(btd)
BPEC: 110175184
MALB: 109968104
ELS: 105012460(btd)
SFM: 108933388
LCM: 102358398 102358664(BTD)
CMK: 103181262(btd)
DSI: Dsimw501_GD16207(Dsim_GD16207)
BIM: 100740669
BTER: 100647835
DPA: 109541661
API: 100165187
DNX: 107162221
 » show all
Taxonomy
Reference
1  [PMID:14087327]
  Authors
KNAPPE J, BRUEMMER W, BIEDERBICK K.
  Title
[PURIFICATION AND PROPERTIES OF BIOTINIDASE FROM SWINE KIDNEY AND LACTOBACILLUS CASEI.]
  Journal
Biochem Z 338:599-613 (1963)
Reference
2  [PMID:13211594]
  Authors
THOMA RW, PETERSON WH.
  Title
The enzymatic degradation of soluble bound biotin.
  Journal
J Biol Chem 210:569-79 (1954)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.12
IUBMB Enzyme Nomenclature: 3.5.1.12
ExPASy - ENZYME nomenclature database: 3.5.1.12
BRENDA, the Enzyme Database: 3.5.1.12
CAS: 9025-15-4

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