KEGG   ENZYME: 3.5.1.23Help
Entry
EC 3.5.1.23                 Enzyme                                 

Name
ceramidase;
acylsphingosine deacylase;
glycosphingolipid ceramide deacylase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N-acylsphingosine amidohydrolase
Reaction(IUBMB)
a ceramide + H2O = a carboxylate + sphingosine [RN:R01493]
Reaction(KEGG)
Substrate
ceramide [CPD:C00195];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
sphingosine [CPD:C00319]
History
EC 3.5.1.23 created 1972, modified 1990
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K01441  alkaline ceramidase
K12348  acid ceramidase
K12349  neutral ceramidase
Genes
HSA: 125981(ACER1) 340485(ACER2) 427(ASAH1) 56624(ASAH2)
PTR: 450461 464022(ASAH1) 465015(ACER2) 468681(ACER1)
PPS: 100971165(ACER2) 100985247(ASAH2) 100988247(ACER1) 100991999(ASAH1)
GGO: 101131822(ACER1) 101133313(ACER2) 101139980 101146782(ASAH2) 101149522(ASAH1)
PON: 100171626(ASAH1) 100437358(ACER1) 100437539 100444981(ACER2)
NLE: 100579536(ASAH1) 100593201(ACER1) 100599629(ASAH2) 100600904(ACER2)
MCC: 699093(ACER1) 703699(ASAH1) 703913(ASAH2) 712170(ACER2)
MCF: 102118393(ASAH1) 102122205(ACER2) 102122495(ACER1) 102125051(ASAH2)
CSAB: 103215400(ASAH1) 103216197(ASAH2) 103219398(ACER2) 103233765 103234341
RRO: 104655223(ASAH1) 104664247(ACER2) 104665375(ACER1) 104670344(ASAH2B) 104675174(ASAH2)
RBB: 108526237(ACER1) 108526474(ASAH1) 108527549 108540842(ACER2)
CJC: 100390425(ASAH2) 100409902(ASAH1) 100411393(ACER1) 100413010(ACER2)
SBQ: 101038220(ACER2) 101042224(ASAH2) 101044863(ASAH1) 101049636(ACER1)
MMU: 11886(Asah1) 171168(Acer1) 230379(Acer2) 54447(Asah2)
RNO: 114104(Asah2) 301118(Acer1) 313339(Acer2) 84431(Asah1)
CGE: 100758912(Acer2) 100765841(Asah2) 100771068(Asah1) 100773997(Acer1)
NGI: 103731327(Asah2) 103737194(Acer1) 103743960(Acer2) 103748255(Asah1)
HGL: 101702052(Acer1) 101709668(Asah2) 101723877(Acer2) 101724913(Asah1)
CCAN: 109681824(Asah2) 109688226(Acer1) 109692105(Asah1) 109698300(Acer2)
OCU: 100337862(ACER2) 100338209(ASAH1) 100357548(ACER1) 100357673(ASAH2)
TUP: 102473431(ACER1) 102487994(ASAH2) 102489806(ACER2) 102490603(ASAH1)
CFA: 100856386(ACER2) 482897(ASAH1) 486461(ASAH2) 611739(ACER1)
AML: 100471144(ACER1) 100471625(ASAH1) 100471748(ASAH2) 100475315(ACER2)
UMR: 103661994(ASAH2) 103662155(ACER2) 103681376(ASAH1) 103681704(ACER1)
ORO: 101363287(ACER1) 101371027(ASAH2) 101377033(ACER2) 101384361(ASAH1)
FCA: 101082231(ASAH1) 101095079(ACER1) 101097670(ASAH2) 101098748(ACER2)
PTG: 102953263(ACER1) 102956747(ASAH2) 102961847(ACER2) 102967391(ASAH2B) 102969154(ASAH1)
AJU: 106970984(ACER2) 106975478(ACER1) 106980970(ASAH2) 106988336(ASAH1)
BTA: 100336736(ASAH2) 510620(ASAH1) 518021(ACER1) 540732(ACER2)
BOM: 102269704(ASAH2) 102278175(ACER1) 102279101(ACER2) 102280046(ASAH2B) 102285015(ASAH1)
BIU: 109553501(ASAH1) 109561210(ACER1) 109562861(ACER2) 109578966(ASAH2)
PHD: 102317726(ASAH2B) 102326915(ASAH1) 102328057(ACER2) 102343926(ACER1)
CHX: 102169733(ASAH1) 102179093(ACER1) 102183323(ACER2) 102183481(ASAH2)
OAS: 101106585(ACER1) 101117904(ASAH1) 101121732(ASAH2) 101123535(ACER2)
SSC: 100155321(ACER2) 100157065(ASAH2) 100512932(ASAH1) 100622165(ACER1)
CFR: 102503558(ACER1) 102503963(ASAH1) 102509981(ASAH2) 102514300(ACER2)
CDK: 105091768(ACER1) 105095941(ACER2) 105102375(ASAH1) 105105273(ASAH2)
BACU: 103000406(ACER1) 103004029(ACER2) 103004383(ASAH1) 103014205(ASAH2B)
LVE: 103073009(ASAH2B) 103079659(ACER2) 103079872(ACER1) 103084758(ASAH1)
OOR: 101274534(ACER2) 101276356(ASAH1) 101278345(ACER1) 101280545(ASAH2)
ECB: 100054433(ASAH1) 100063894(ACER2) 100071829(ASAH2) 100147512(ACER1)
EPZ: 103540540(ACER1) 103549842(ASAH2) 103556309(ASAH1) 103557519(ACER2)
EAI: 106828200(ASAH1) 106832753(ACER1) 106834022(ACER2) 106845889 106847425
MYB: 102248194(ACER2) 102250405(ACER1) 102261355(ASAH1) 102263955(ASAH2)
MYD: 102752227(ASAH2) 102765212(ACER2) 102770477(ACER1) 102772524(ASAH1)
HAI: 109377289 109387522(ASAH2) 109388589(ACER1) 109391488(ACER2) 109394586(ASAH1)
RSS: 109434069(ACER1) 109450556(ASAH1) 109450898(ASAH2) 109457447(ACER2)
PALE: 102879619(ACER1) 102881257(ASAH2) 102884758(ASAH1) 102891396(ACER2)
LAV: 100658494(ASAH1) 100660560(ASAH2) 100667481(ACER2) 100674279(ACER1)
MDO: 100010255(ACER2) 100021204(ASAH1) 100022761(ASAH2) 100025621(ACER1)
SHR: 100927628(ASAH1) 100927914(ACER2) 100928486(ASAH2) 100932838
OAA: 100075060(ASAH2) 100075240 100090760 100093499(ASAH1) 103170972(ACER1)
GGA: 420088(ACER1) 422727(ASAH1) 423679(ASAH2) 427235(ACER2)
MGP: 100540199(ACER2) 100540641(ASAH2) 100544991(ACER1) 100550236(ASAH1)
CJO: 107306169(ACER2) 107313735(ASAH1) 107315615 107325653(ACER1)
APLA: 101799654(ACER2) 101801719(ASAH1) 101802423(ASAH2) 101802706(ACER1)
ACYG: 106034302(ASAH2) 106035211(ASAH1) 106044153(ACER2) 106048423(ACER1)
TGU: 100219353(ASAH2) 100223185(ASAH1) 100223513(ACER2) 100228153(ACER1)
GFR: 102035543(ACER1) 102041139(ASAH2) 102043064(ACER2) 102045042(ASAH1)
FAB: 101806040(ASAH1) 101808147(ASAH2) 101810270(ACER1) 101822223(ACER2)
PHI: 102105858(ACER2) 102107805(ACER1) 102108790(ASAH1) 102109084(ASAH2)
PMAJ: 107203488(ASAH1) 107206528(ASAH2) 107215346(ACER1) 107216012(ACER2)
CCAE: 111928436(ASAH1) 111931637 111940433(ACER1) 111940658(ACER2) 111943943
CCW: 104685277(ACER2) 104690859(ASAH1) 104695104 104696975(ACER1)
FPG: 101915172(ACER2) 101917300(ASAH1) 101917767(ACER1) 101922478(ASAH2)
FCH: 102045851(ASAH1) 102053013(ACER2) 102054876(ASAH2) 102059388(ACER1)
CLV: 102090506(ACER1) 102092849(ACER2) 102098583(ASAH1) 102098837
EGZ: 104124343(ACER1) 104125150(ASAH2) 104127360(ACER2) 104129441(ASAH1)
AAM: 106489032(ASAH2) 106489106(ACER2) 106490075(ASAH1) 106491134(ACER1)
ASN: 102378268(ACER1) 102382436(ACER2) 102383990(ASAH1) 102387682(ASAH2)
AMJ: 102560929(ACER1) 102561354(ASAH2) 102562039(ACER2) 102566045(ASAH1)
PSS: 102444687(ASAH1) 102445820(ACER1) 102447768(ACER2) 102460189(ASAH2)
CMY: 102930137(ASAH1) 102938323(ACER2) 102938631(ACER1) 102945456(ASAH2B)
CPIC: 101934722(ACER1) 101941399(ACER2) 101944232(ASAH1) 101947675(ASAH2)
ACS: 100552754(asah2) 100559712(acer2) 100565312(asah1)
PVT: 110072473(ACER1) 110077369(ACER2) 110077885(ASAH1) 110084120(ASAH2)
PBI: 103049621 103052913(ASAH1) 103056593(ACER1) 103059643(ACER2) 103060263
GJA: 107108734(ASAH1) 107118237(ACER1) 107121645(ASAH2) 107124334(ACER2)
XLA: 108695739 108696963(asah2.L) 108712779(acer1.L) 108713812(acer2.L) 447327(asah1.L) 779231(acer2.S)
XTR: 100127603(acer1) 100170585(asah2) 100485700(asah1) 100494440 549870(acer2)
NPR: 108785692(ASAH1) 108787343(ACER2) 108794024 108796882 108800207(ACER1)
DRE: 100331179(acer2) 393549(asah1b) 450068(asah1a) 493602(asah2) 550266(acer1)
IPU: 100528685(acer2) 108260615(ACER2) 108260777(asah1) 108264991(acer1) 108269357(ASAH1) 108274155(asah2)
TRU: 101065149(asah1) 101069568(acer1) 101071183 101072604 101077052(acer2)
LCO: 104921822(acer1) 104930183(acer2) 104936727(asah2) 104936951(asah1)
NCC: 104950292(acer2) 104950330 104964860(acer1) 104967119(asah1)
MZE: 101464591(acer2) 101467490(acer1) 101476420(asah1) 101482863(asah2) 112434916
OLA: 101161703(asah1) 101163299(acer2) 101165218(asah2) 101170916(acer1)
XMA: 102218557(acer2) 102227444(asah2) 102231620(asah1) 102236334(acer1)
PRET: 103461639(asah1) 103466024(acer2) 103468236(acer1) 103482088
NFU: 107373323(asah1) 107375254(acer2) 107387510(asah2) 107392883(acer1)
KMR: 108229504 108229571 108231238(acer2) 108233727(asah1) 108238373(acer1)
CSEM: 103382244(asah2) 103383649(acer2) 103384334(asah1) 103394911(acer1)
SDU: 111216721(asah1) 111219686(asah2) 111231380(acer2) 111240462(acer1)
HCQ: 109509138 109511169(asah1) 109518534(asah2) 109518945(acer1) 109519876(acer2)
BPEC: 110165334(acer2) 110166065(asah2) 110167588(asah1) 110167938(acer1)
MALB: 109961376(acer2) 109961696(acer1) 109969663(asah2) 109972118(asah1)
ELS: 105006219 105011637(acer1) 105022111(acer2) 105022854(asah1)
SFM: 108919829(acer1) 108924408(asah1) 108925722 108938761(acer2) 108939518(asah2)
LCM: 102348678(ACER2) 102355598(ASAH2) 102355600(ASAH1) 102358287(ACER1)
DME: Dmel_CG13969(bwa) Dmel_CG1471(CDase)
DSI: Dsimw501_GD21520(Dsim_GD21520) Dsimw501_GD24242(Dsim_GD24242)
DYA: Dyak_GE10878(Dyak_CDase) Dyak_GE13293
DPA: 109539809
PXY: 105396992
API: 100165996
DNX: 107167451
CLEC: 106665047
CEL: CELE_F27E5.1(asah-2) CELE_K11D2.2(asah-1) CELE_W02F12.2(W02F12.2)
CBR: CBG00863 CBG15381(Cbr-asah-1) CBG18997
BMY: Bm1_42130
TSP: Tsp_09460
OBI: 106876330
SHX: MS3_10036
EGL: EGR_06583
HMG: 100206178
LJA: Lj0g3v0208009.1(Lj0g3v0208009.1) Lj0g3v0212329.1(Lj0g3v0212329.1) Lj0g3v0212329.2(Lj0g3v0212329.2) Lj2g3v3336140.1(Lj2g3v3336140.1) Lj6g3v0635260.1(Lj6g3v0635260.1) Lj6g3v0635260.2(Lj6g3v0635260.2)
SLY: 101251446
SOT: 102606157
BVG: 104900023
SOE: 110778561
NNU: 104593520
OSA: 4326680
DOSA: Os01t0624000-01(Os01g0624000)
OBR: 102715249
BDI: 100837567
ATS: 109766002(LOC109766002) 109766004(LOC109766004) 109785808(LOC109785808)
ZMA: 100279713(cl24314_1) 103629203 111589575
APRO: F751_1851
NTE: NEUTE1DRAFT131682(NEUTE1DRAFT_131682) NEUTE1DRAFT76518(NEUTE1DRAFT_76518)
MBE: MBM_05062
ANI: AN4245.2
ANG: ANI_1_1412164(An18g05500)
ABE: ARB_01232
TVE: TRV_01275
PTE: PTT_13176
ABP: AGABI1DRAFT112961(AGABI1DRAFT_112961)
ABV: AGABI2DRAFT192931(AGABI2DRAFT_192931)
DDI: DDB_G0268374(dcd2B) DDB_G0293538(dcd2A)
SMIN: v1.2.005120.t1(symbB.v1.2.005120.t1) v1.2.007250.t1(symbB.v1.2.007250.t1) v1.2.025307.t1(symbB.v1.2.025307.t1) v1.2.026056.t1(symbB.v1.2.026056.t1) v1.2.026056.t2(symbB.v1.2.026056.t2) v1.2.029508.t1(symbB.v1.2.029508.t1) v1.2.031961.t1(symbB.v1.2.031961.t1)
PAE: PA0845
PAEV: N297_872(dcd2A)
PAEI: N296_872(dcd2A)
PAEP: PA1S_22220
PAEM: U769_21590
PAEL: T223_22855
PAEG: AI22_11720
PAEC: M802_868(dcd2A)
PAEO: M801_872(dcd2A)
ADI: B5T_02488
APAC: S7S_07645
AXE: P40_12080
MXA: MXAN_0613
MTU: Rv0669c
MRA: MRA_0679
MTUR: CFBS_0704
MTD: UDA_0669c
MTUC: J113_04760
MTUE: J114_03575
MTUH: I917_04770
MTUL: TBHG_00664
MTUT: HKBT1_0704
MTUU: HKBT2_0705
MBB: BCG_0718c
MBT: JTY_0688
MBX: BCGT_0460
MAF: MAF_06780
MMI: MMAR_0997
MHAD: B586_03915
ASD: AS9A_2567
CJK: jk1103(asa)
CRD: CRES_1191(asa)
CVA: CVAR_1079
CTER: A606_04245
COA: DR71_2081
NFA: NFA_6470
RER: RER_07640
REY: O5Y_03715
REQ: REQ_06850
GBR: Gbro_2003
GOR: KTR9_1931
TPR: Tpau_2570
SGR: SGR_6570
SGB: WQO_02270
SALS: SLNWT_0663
SFI: SFUL_684
SPRI: SPRI_6615
SEN: SACE_3165
AOI: AORI_3695
SESP: BN6_43580
ACTN: L083_4617
AFS: AFR_19975
CAI: Caci_0673
AMR: AM1_E0115
LBF: LBF_2410
GBA: J421_5535
TMAR: MARIT_2033
 » show all
Taxonomy
Reference
1  [PMID:5775951]
  Authors
Nilsson A.
  Title
The presence of spingomyelin- and ceramide-cleaving enzymes in the small intestinal tract.
  Journal
Biochim Biophys Acta 176:339-47 (1969)
DOI:10.1016/0005-2760(69)90192-1
Reference
2  [PMID:5805303]
  Authors
Yavin E, Gatt S.
  Title
Enzymatic hydrolysis of sphingolipids. 8. Further purification and properties of rat brain ceramidase.
  Journal
Biochemistry 8:1692-8 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.23
IUBMB Enzyme Nomenclature: 3.5.1.23
ExPASy - ENZYME nomenclature database: 3.5.1.23
BRENDA, the Enzyme Database: 3.5.1.23
CAS: 37289-06-8

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