KEGG   ENZYME: 3.5.1.48Help
Entry
EC 3.5.1.48                 Enzyme                                 

Name
acetylspermidine deacetylase;
N8-monoacetylspermidine deacetylase;
N8-acetylspermidine deacetylase;
N-acetylspermidine deacetylase;
N1-acetylspermidine amidohydrolase (incorrect);
8-N-acetylspermidine amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N8-acetylspermidine amidohydrolase
Reaction(IUBMB)
N8-acetylspermidine + H2O = acetate + spermidine [RN:R07300]
Reaction(KEGG)
Substrate
N8-acetylspermidine [CPD:C01029];
H2O [CPD:C00001]
Product
acetate [CPD:C00033];
spermidine [CPD:C00315]
Comment
It was initially thought that N1-acetylspermidine was the substrate for this deacetylase reaction [1] but this has since been disproved by Marchant et al. [3].
History
EC 3.5.1.48 created 1984, modified 2005
Reference
1  [PMID:28089]
  Authors
Libby PR.
  Title
Properties of an acetylspermidine deacetylase from rat liver.
  Journal
Arch Biochem Biophys 188:360-3 (1978)
DOI:10.1016/S0003-9861(78)80020-4
Reference
2  [PMID:708044]
  Authors
Blankenship J.
  Title
Deacetylation of N8-acetylspermidine by subcellular fractions of rat tissue.
  Journal
Arch Biochem Biophys 189:20-7 (1978)
DOI:10.1016/0003-9861(78)90109-1
Reference
3  [PMID:3955076]
  Authors
Marchant P, Manneh VA, Blankenship J.
  Title
N1-acetylspermidine is not a substrate for N-acetylspermidine deacetylase.
  Journal
Biochim Biophys Acta 881:297-9 (1986)
DOI:10.1016/0304-4165(86)90017-6
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.48
IUBMB Enzyme Nomenclature: 3.5.1.48
ExPASy - ENZYME nomenclature database: 3.5.1.48
BRENDA, the Enzyme Database: 3.5.1.48
CAS: 67339-07-5

DBGET integrated database retrieval system