KEGG   ENZYME: 3.5.1.52Help
Entry
EC 3.5.1.52                 Enzyme                                 

Name
peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase;
glycopeptide N-glycosidase;
glycopeptidase;
N-oligosaccharide glycopeptidase;
N-glycanase;
Jack-bean glycopeptidase;
PNGase A;
PNGase F
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase
Reaction(IUBMB)
Hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue [RN:R08707]
Reaction(KEGG)
Comment
Does not act on (GlcNAc)Asn, because it requires the presence of more than two amino-acid residues in the substrate [cf. EC 3.5.1.26, N4-(beta-N-acetylglucosaminyl)-L-asparaginase]. The plant enzyme was previously erroneously listed as EC 3.2.2.18.
History
EC 3.5.1.52 created 1984, modified 1989 (EC 3.2.2.18 created 1984, incorporated 1989)
Orthology
K01456  peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase
Genes
HSA: 55768(NGLY1)
PTR: 460233(NGLY1)
PPS: 100990785(NGLY1)
GGO: 101129625(NGLY1)
PON: 100438095(NGLY1)
NLE: 100598050(NGLY1)
MCC: 700842(NGLY1)
MCF: 101925902(NGLY1)
CSAB: 103241778(NGLY1)
RRO: 104658078(NGLY1)
RBB: 108543075(NGLY1)
CJC: 100397719(NGLY1)
SBQ: 101053768(NGLY1)
MMU: 59007(Ngly1)
RNO: 361014(Ngly1)
CGE: 100770329(Ngly1)
NGI: 103734260(Ngly1)
HGL: 101696317(Ngly1)
CCAN: 109696873(Ngly1)
OCU: 100351931(NGLY1)
TUP: 102495051(NGLY1)
CFA: 100682555(NGLY1)
AML: 100468440(NGLY1)
UMR: 103679804(NGLY1)
ORO: 101376124(NGLY1)
FCA: 101086171(NGLY1)
PTG: 102960324(NGLY1)
AJU: 106988243(NGLY1)
BTA: 533736(NGLY1)
BOM: 102274847(NGLY1)
BIU: 109553459(NGLY1)
PHD: 102333201(NGLY1)
CHX: 102171687(NGLY1)
OAS: 101122164(NGLY1)
SSC: 100522951(NGLY1)
CFR: 102522193(NGLY1)
CDK: 105095627(NGLY1)
BACU: 103002175(NGLY1)
LVE: 103081982(NGLY1)
OOR: 101269797(NGLY1)
ECB: 100059456(NGLY1)
EAI: 106823874(NGLY1)
MYB: 102252924(NGLY1)
HAI: 109374238(NGLY1)
RSS: 109454541(NGLY1)
PALE: 102886961(NGLY1)
LAV: 100674928(NGLY1)
TMU: 101357799
MDO: 100031666(NGLY1)
SHR: 100930637(NGLY1)
OAA: 100075786(NGLY1)
GGA: 420655(NGLY1)
MGP: 100545789(NGLY1)
CJO: 107309294(NGLY1)
APLA: 101795106(NGLY1)
ACYG: 106030294(NGLY1)
TGU: 100228315(NGLY1)
GFR: 102040046(NGLY1)
FAB: 101814726(NGLY1)
PHI: 102110753(NGLY1)
PMAJ: 107200257(NGLY1)
CCAE: 111923483(NGLY1)
CCW: 104689052(NGLY1)
FPG: 101913196(NGLY1)
FCH: 102059937(NGLY1)
CLV: 102097019(NGLY1)
EGZ: 104122964(NGLY1)
AAM: 106483561(NGLY1)
ASN: 102383348(NGLY1)
AMJ: 102571009(NGLY1)
PSS: 102453461(NGLY1)
CMY: 102930072(NGLY1)
CPIC: 101954099(NGLY1)
ACS: 100562703(ngly1)
PVT: 110086656(NGLY1)
PBI: 103064120(NGLY1)
GJA: 107107877(NGLY1)
XLA: 108718927(ngly1.L) 733299(ngly1.S)
XTR: 100488447(ngly1)
NPR: 108798323(NGLY1)
DRE: 553627(ngly1)
CCAR: 109066243 109066324(ngly1)
IPU: 108272784(ngly1)
AMEX: 103035113(ngly1)
TRU: 101075603(ngly1)
LCO: 104931642(ngly1)
NCC: 104960819(ngly1) 104960823
MZE: 101466274(ngly1)
OLA: 101157466(ngly1)
XMA: 102234369(ngly1)
PRET: 103471954(ngly1)
NFU: 107383243(ngly1)
KMR: 108250608(ngly1)
CSEM: 103394324(ngly1)
LCF: 108900255
SDU: 111230544(ngly1)
HCQ: 109518651(ngly1)
BPEC: 110153760(ngly1)
MALB: 109972158(ngly1)
SASA: 100380716(ngly1)
OTW: 112229621(ngly1)
ELS: 105012551(ngly1)
SFM: 108933276(ngly1)
LCM: 102345970(NGLY1)
CMK: 103179950(ngly1)
CIN: 100181653
SPU: 100890545
APLC: 110985918
SKO: 102806854
DME: Dmel_CG7865(Pngl)
DSI: Dsimw501_GD10391(Dsim_GD10391)
MDE: 101897256
AAG: 5564537
AME: 409032
BIM: 100742826
BTER: 100651042
SOC: 105200509
AEC: 105145198
ACEP: 105617818
PBAR: 105424317
HST: 105182339
DQU: 106745963
CFO: 105256331
LHU: 105680031
PGC: 109852162
PCF: 106785852
NVI: 100119034
MDL: 103579494
TCA: 664307
DPA: 109541665
NVL: 108565778
BMOR: 101738189
PMAC: 106716584
PRAP: 110991693
HAW: 110379735
PXY: 105380342
API: 103309281
DNX: 107164692
CLEC: 106670469
ZNE: 110840553
FCD: 110842137
TUT: 107363242
CEL: CELE_F56G4.5(png-1)
CBR: CBG08042(Cbr-png-1)
BMY: Bm1_49720
CRG: 105344128
MYI: 110447229
OBI: 106870946
SHX: MS3_07508
EGL: EGR_08056
ATH: AT5G49570(PNG1)
CRB: 17876262
BRP: 103874613
BOE: 106306515
THJ: 104818635
CPAP: 110809635
CIT: 102606837
TCC: 18600220
GRA: 105804695
DZI: 111277193
VRA: 106776150
VAR: 108345770
CCAJ: 109795837
CAM: 101499244
ADU: 107492052
AIP: 107645828
LANG: 109345765
FVE: 101300925
PPER: 18772929
PMUM: 103318626
PAVI: 110759671
MDM: 103451022
PXB: 103954417
CSV: 101221843
CMO: 103495944
MCHA: 111013072
CMAX: 111465478
CMOS: 111444002
RCU: 8289346
JCU: 105647681
HBR: 110656768
POP: 7473932
JRE: 108995241
VVI: 100253765
SLY: 100736452
SPEN: 107007876
SOT: 102587491
CANN: 107839429
NTA: 107781868
NSY: 104221647
NTO: 104109282
INI: 109180787
SIND: 105172275
OEU: 111386813
HAN: 110878305
LSV: 111882880
CCAV: 112515110
DCR: 108202983
BVG: 104891118
SOE: 110796519
NNU: 104599773
OSA: 4343301
DOSA: Os07t0497400-01(Os07g0497400)
OBR: 102701646
BDI: 100836739
ATS: 109753701(LOC109753701)
SBI: 8077463
ZMA: 100304380(pco129049)
SITA: 101784520
PDA: 103713528
EGU: 105046814
MUS: 103982116
DCT: 110096158
PEQ: 110030910
AOF: 109833418
ATR: 18443204
PPP: 112281750
MNG: MNEG_7814
APRO: F751_3612
SCE: YPL096W(PNG1)
ERC: Ecym_7068
KMX: KLMA_10796(PNG1)
NCS: NCAS_0C01930(NCAS0C01930)
NDI: NDAI_0E02650(NDAI0E02650)
TPF: TPHA_0A01280(TPHA0A01280)
TBL: TBLA_0H03830(TBLA0H03830)
TDL: TDEL_0A05180(TDEL0A05180)
KAF: KAFR_0E00750(KAFR0E00750)
CAL: CAALFM_C206490WA(CaO19.26)
NCR: NCU00651(un-7)
NTE: NEUTE1DRAFT126890(NEUTE1DRAFT_126890)
MGR: MGG_03598
SSCK: SPSK_05200
MAW: MAC_05543
MAJ: MAA_05166
CMT: CCM_07622
BFU: BCIN_01g01080(Bcpng1)
MBE: MBM_00910
ANI: AN3787.2
ANG: ANI_1_1076064(An07g08690)
ABE: ARB_06215
TVE: TRV_01685
PTE: PTT_14197
CNE: CNC01650
CNB: CNBC5610
DFA: DFA_07680
SMIN: v1.2.030590.t1(symbB.v1.2.030590.t1)
NGD: NGA_0690100(NGLY1)
SPAR: SPRG_19255
 » show all
Taxonomy
Reference
1  [PMID:7287707]
  Authors
Plummer TH Jr, Tarentino AL.
  Title
Facile cleavage of complex oligosaccharides from glycopeptides by almond emulsin peptide: N-glycosidase.
  Journal
J Biol Chem 256:10243-6 (1981)
Reference
2  [PMID:901470]
  Authors
Takahashi N.
  Title
Demonstration of a new amidase acting on glycopeptides.
  Journal
Biochem Biophys Res Commun 76:1194-201 (1977)
DOI:10.1016/0006-291X(77)90982-2
Reference
3  [PMID:738997]
  Authors
Takahashi N, Nishibe H.
  Title
Some characteristics of a new glycopeptidase acting on aspartylglycosylamine linkages.
  Journal
J Biochem (Tokyo) 84:1467-73 (1978)
Reference
4  [PMID:4063349]
  Authors
Tarentino AL, Gomez CM, Plummer TH Jr.
  Title
Deglycosylation of asparagine-linked glycans by peptide:N-glycosidase F.
  Journal
Biochemistry 24:4665-71 (1985)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.52
IUBMB Enzyme Nomenclature: 3.5.1.52
ExPASy - ENZYME nomenclature database: 3.5.1.52
BRENDA, the Enzyme Database: 3.5.1.52
CAS: 83534-39-8

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