KEGG   ENZYME: 3.5.1.90Help
Entry
EC 3.5.1.90                 Enzyme                                 

Name
adenosylcobinamide hydrolase;
CbiZ;
AdoCbi amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
adenosylcobinamide amidohydrolase
Reaction(IUBMB)
adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol [RN:R05226]
Reaction(KEGG)
Substrate
adenosylcobinamide [CPD:C06508];
H2O [CPD:C00001]
Product
adenosylcobyric acid [CPD:C06507];
(R)-1-aminopropan-2-ol [CPD:C03194]
Comment
Involved in the salvage pathway of cobinamide in archaea. Archaea convert adenosylcobinamide (AdoCbi) into adenosylcobinamide phosphate (AdoCbi-P) in two steps. First, the amidohydrolase activity of CbiZ cleaves off the aminopropanol moiety of AdoCbi yielding adenosylcobyric acid (AdoCby); second, AdoCby is converted into AdoCbi-P by the action of EC 6.3.1.10, adenosylcobinamide-phosphate synthase (CbiB).
History
EC 3.5.1.90 created 2004
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
Orthology
K08260  adenosylcobinamide hydrolase
Genes
AFU: AF_1400
AFG: AFULGI_00015110
AVE: Arcve_1003
AST: Asulf_00935
FPL: Ferp_2081
GAC: GACE_1857
GAH: GAH_01724
FAC: FACI_IFERC01G1896
PHO: PH0814(PH0814)
PAB: PAB1708
PFU: PF0305
PFI: PFC_00600
PYN: PNA2_0142
TKO: TK0846
TON: TON_0689
TGA: TGAM_0516(cbiZ)
THE: GQS_01490
THA: TAM4_743
THM: CL1_2012
TLT: OCC_11919
THS: TES1_0965
TNU: BD01_0588
TEU: TEU_09185
PPAC: PAP_03150
MAC: MA_1623
MBAR: MSBR2_0064
MMA: MM_0173
MMAC: MSMAC_2488
METM: MSMTP_1142
MHOR: MSHOH_1351
MBU: Mbur_1001
MHU: Mhun_2543
MBG: BN140_2491(cbiZ)
MEMA: MMAB1_3351(cbiZ)
MPI: Mpet_0148
MBN: Mboo_0181
MPL: Mpal_0026
MPD: MCP_2916(cbiZ)
MEZ: Mtc_0313
RCI: RCIX826
HAL: VNG_1583C
HSL: OE_3261F(cbiZ)
HHB: Hhub_2918(cbiZ)
HALH: HTSR_1763(cbiZ)
HHSR: HSR6_1829(cbiZ)
HSU: HLASF_0298(cbiZ)
HSF: HLASA_0297(cbiZ)
HMA: rrnAC1935
HHI: HAH_2444
NPH: NP_5300A(cbiZ)
NMO: Nmlp_2452(cbiZ)
HUT: Huta_2500
HMU: Hmuk_0140
HWA: HQ_1406A(cbiZ)
HWC: Hqrw_1482(cbiZ)
HVO: HVO_0592(cbiZ)
HME: HFX_0579(cbiZ)
HLA: Hlac_0236
HTU: Htur_2838
NMG: Nmag_0992(cbiZ)
NAT: NJ7G_1620
 » show all
Taxonomy
Reference
1  [PMID:14990804]
  Authors
Woodson JD, Escalante-Semerena JC.
  Title
CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea.
  Journal
Proc Natl Acad Sci U S A 101:3591-6 (2004)
DOI:10.1073/pnas.0305939101
  Sequence
[mma:MM_0173] [hal:VNG_1583C]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.90
IUBMB Enzyme Nomenclature: 3.5.1.90
ExPASy - ENZYME nomenclature database: 3.5.1.90
BRENDA, the Enzyme Database: 3.5.1.90
CAS: 905988-16-1

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