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Entry
EC 3.5.1.94                 Enzyme                                 

Name
gamma-glutamyl-gamma-aminobutyrate hydrolase;
gamma-glutamyl-GABA hydrolase;
PuuD;
YcjL;
4-(gamma-glutamylamino)butanoate amidohydrolase;
4-(L-gamma-glutamylamino)butanoate amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
4-(gamma-L-glutamylamino)butanoate amidohydrolase
Reaction(IUBMB)
4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate [RN:R07419]
Reaction(KEGG)
Substrate
4-(gamma-L-glutamylamino)butanoate [CPD:C15767];
H2O [CPD:C00001]
Product
4-aminobutanoate [CPD:C00334];
L-glutamate [CPD:C00025]
Comment
Forms part of a putrescine-utilizing pathway in Escherichia coli, in which it has been hypothesized that putrescine is first glutamylated to form gamma-glutamylputrescine, which is oxidized to 4-(gamma-glutamylamino)butanal and then to 4-(gamma-glutamylamino)butanoate. The enzyme can also catalyse the reactions of EC 3.5.1.35 (D-glutaminase) and EC 3.5.1.65 (theanine hydrolase).
History
EC 3.5.1.94 created 2006, modified 2011
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K09473  gamma-glutamyl-gamma-aminobutyrate hydrolase
Genes
ECO: b1298(puuD)
ECJ: JW1291(puuD)
ECD: ECDH10B_1415(puuD)
EBW: BWG_1130(puuD)
ECOK: ECMDS42_1096(puuD)
ECE: Z2490(ycjL)
ECS: ECs1875(puuD)
ECF: ECH74115_1940(puuD)
ETW: ECSP_1823(puuD)
ELX: CDCO157_1795(puuD)
EOJ: ECO26_1865(puuD)
EOI: ECO111_1681(puuD)
EOH: ECO103_1462(puuD)
ECOO: ECRM13514_1724(puuD)
ECOH: ECRM13516_1689(puuD)
EOK: G2583_1645(puuD)
ELR: ECO55CA74_08010(puuD)
ESO: O3O_11790(puuD)
ESM: O3M_13815(puuD)
ESL: O3K_13840(puuD)
ECW: EcE24377A_1508(puuD)
ELH: ETEC_1402
ECX: EcHS_A1413(puuD)
ECM: EcSMS35_1824(puuD)
ECY: ECSE_1350
ECR: ECIAI1_1323(puuD)
ECK: EC55989_1460(puuD)
ECT: ECIAI39_1649(puuD)
EOC: CE10_1546(puuD)
EUM: ECUMN_1604(puuD)
ELO: EC042_1426(puuD)
EBR: ECB_01275(ycjL)
EBD: ECBD_2319
EKF: KO11_16320(puuB)
EDJ: ECDH1ME8569_1240(puuD)
ELW: ECW_m1394(puuB)
ELL: WFL_06795(puuB)
ELP: P12B_c1796(puuD)
EBL: ECD_01275(puuD)
EBE: B21_01286(puuD)
ECOA: APECO78_10365(puuD)
ECOL: LY180_06610(puuD)
EAL: EAKF1_ch0120c(puuD)
SFL: SF1303(puuD)
SFX: S1385(ycjL)
SFV: SFV_1312(ycjL)
SFE: SFxv_1476(puuD)
SFN: SFy_1872
SFS: SFyv_1930
SFT: NCTC1_01378(puuD)
SSN: SSON_1842(ycjL)
SHQ: A0259_10615(puuD)
ENO: ECENHK_09940(puuD)
ENL: A3UG_10015(puuD)
ESA: ESA_02079
CSK: ES15_1440 ES15_2236(puuD)
CTU: CTU_18850(puuD)
KPN: KPN_01020
KPU: KP1_2005
KPP: A79E_3213
KPE: KPK_3540(puuD)
KPO: KPN2242_08160(puuD)
KPR: KPR_3502(puuD)
KPJ: N559_3267
KPI: D364_05305(puuD)
KPX: PMK1_03360(puuD)
KPNU: LI86_16975
KPNK: BN49_2108(puuD)
KVA: Kvar_3359
KOX: KOX_16930(puuD)
KOE: A225_2234
KOY: J415_20605(puuD)
EAE: EAE_15930(puuD)
EAR: CCG30721
CRO: ROD_03571(puuD)
ROR: RORB6_09560(puuD)
EBF: D782_2780
PSTS: E05_49390
SPE: Spro_2067
SRL: SOD_c18790(puuD)
SRY: M621_10365(puuD)
SPLY: Q5A_010395(puuD)
SMAF: D781_1891
SMW: SMWW4_v1c20860(puuD)
SMAR: SM39_1530(puuD)
SMAC: SMDB11_1340(puuD)
SLQ: M495_10020(puuD)
SERF: L085_18335(puuD)
SERS: SERRSCBI_09775(puuD)
RAA: Q7S_07625(puuD)
EBI: EbC_29020(puuD)
EGE: EM595_2350(puuD)
PAM: PANA_2463(puuD)
PLF: PANA5342_1623(ycjL)
PAJ: PAJ_1760(puuD)
PVA: Pvag_1946(ycjL)
PSTW: DSJ_15840
OCE: GU3_14520(puuD)
DNO: DNO_0653
 » show all
Taxonomy
Reference
1  [PMID:15590624]
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
  Sequence
[eco:b1298]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.94
IUBMB Enzyme Nomenclature: 3.5.1.94
ExPASy - ENZYME nomenclature database: 3.5.1.94
BRENDA, the Enzyme Database: 3.5.1.94

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