KEGG   ENZYME: 3.5.1.95Help
Entry
EC 3.5.1.95                 Enzyme                                 

Name
N-malonylurea hydrolase;
ureidomalonase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming)
Reaction(IUBMB)
3-oxo-3-ureidopropanoate + H2O = malonate + urea [RN:R07629]
Reaction(KEGG)
R07629;
(other) R10778
Show
Substrate
3-oxo-3-ureidopropanoate [CPD:C15607];
H2O [CPD:C00001]
Product
malonate [CPD:C00383];
urea [CPD:C00086]
Comment
Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.2.1 (barbiturase).
History
EC 3.5.1.95 created 2006
Pathway
ec00240  Pyrimidine metabolism
Orthology
K19795  ureidomalonase
Genes
RHA: RHA1_ro05297
RER: RER_58810
REY: O5Y_28305
REB: XU06_28635
ROP: ROP_27980
ROA: Pd630_LPD01827
RFA: A3L23_03490(aam_3)
SEN: SACE_1914
Taxonomy
Reference
1  [PMID:11485332]
  Authors
Soong CL, Ogawa J, Shimizu S.
  Title
Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase.
  Journal
Biochem Biophys Res Commun 286:222-6 (2001)
DOI:10.1006/bbrc.2001.5356
Reference
2  [PMID:11748240]
  Authors
Soong CL, Ogawa J, Sakuradani E, Shimizu S.
  Title
Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative pyrimidine metabolism.
  Journal
J Biol Chem 277:7051-8 (2002)
DOI:10.1074/jbc.M110784200
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.95
IUBMB Enzyme Nomenclature: 3.5.1.95
ExPASy - ENZYME nomenclature database: 3.5.1.95
BRENDA, the Enzyme Database: 3.5.1.95
CAS: 368888-22-6

DBGET integrated database retrieval system