KEGG   ENZYME: 3.5.1.99Help
Entry
EC 3.5.1.99                 Enzyme                                 

Name
fatty acid amide hydrolase;
FAAH;
oleamide hydrolase;
anandamide amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
fatty acylamide amidohydrolase
Reaction(IUBMB)
(1) anandamide + H2O = arachidonic acid + ethanolamine [RN:R09536];
(2) oleamide + H2O = oleic acid + NH3 [RN:R09537]
Reaction(KEGG)
Substrate
anandamide [CPD:C11695];
H2O [CPD:C00001];
oleamide [CPD:C19670]
Product
arachidonic acid [CPD:C00219];
ethanolamine [CPD:C00189];
oleic acid [CPD:C00712];
NH3 [CPD:C00014]
Comment
Integral membrane protein, the enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide, occurs in mammalia.
History
EC 3.5.1.99 created 2009
Orthology
K15528  fatty acid amide hydrolase
K19176  fatty acid amide hydrolase 2
Genes
HSA: 158584(FAAH2) 2166(FAAH)
PTR: 456559(FAAH) 465664(FAAH2)
PPS: 100973961 100983853(FAAH) 100992327(FAAH2)
GGO: 101139612 101154610(FAAH2)
PON: 100447062(FAAH2) 100453623(FAAH)
NLE: 100588233(FAAH) 100599307(FAAH2)
MCC: 705856(FAAH2) 708660(FAAH)
MCF: 102123918(FAAH2) 102134628(FAAH) 107127535
CSAB: 103224886 103224888 103232067(FAAH2)
RRO: 104657176 104662115 104663245
RBB: 108535628
MMU: 14073(Faah)
RNO: 100911581 29347(Faah)
CGE: 100771171(Faah)
NGI: 103730314(Faah)
HGL: 101713363(Faah2) 101722224(Faah)
CCAN: 109695802
OCU: 100343219(FAAH) 100353626(FAAH2)
TUP: 102489877(FAAH) 102498736
AML: 100472602(FAAH) 105237751
ORO: 101371386
FCA: 101081996 101095511(FAAH)
PTG: 102951924 102971848(FAAH)
AJU: 106973395(FAAH) 106974116
BTA: 513210 540007(FAAH)
BOM: 102283473(FAAH) 102288085
PHD: 102326992(FAAH) 102329117
CHX: 102174994(FAAH) 102175263
SSC: 396949(FAAH)
BACU: 103004815(FAAH)
LVE: 103089901(FAAH)
OOR: 101280037(FAAH)
ECB: 100051756(FAAH) 100070179
EPZ: 103560358(FAAH) 103561029
EAI: 106822606(FAAH) 106833445
MYD: 102752556(FAAH) 102752841 102769353(FAAH2)
HAI: 109373802(FAAH) 109377891(FAAH2)
RSS: 109439254(FAAH2) 109456850 109456888(FAAH)
PALE: 102882624(FAAH2) 102893273(FAAH)
LAV: 100662219(FAAH)
TMU: 101348749
OAA: 100084029(FAAH2)
GGA: 100859568(FAAH2) 395824(VDHAP) 424614(FAAH) 429098
CLV: 102088919(FAAH2) 102098698(FAAH) 102098879
PSS: 102452773(FAAH2) 102455592(FAAH)
XLA: 100036968(faah.1.S) 108698280 108714290(faah.3.L) 108714987(faah.3.S) 108715582
XTR: 100145539(faah.3) 100487591(faah.1) 100488850(faah2) 496823(faah.2)
DRE: 436973(faah2a) 569067(faah) 768298(faah2b)
TRU: 101076695(faah2) 101078866
LCO: 104918497(faah) 104932919(faah2)
NCC: 104958183(faah2) 104966252(faah)
OLA: 101174015(faah) 101174537(faah2)
XMA: 102218255(faah) 102231440(faah2)
PRET: 103463588(faah) 103475965(faah2)
NFU: 107377256(faah2) 107393233(faah)
KMR: 108230777(faah) 108245930(faah2)
CSEM: 103388435(faah2) 103397391(faah)
LCF: 108877404(faah) 108903078(faah2)
SDU: 111232168(faah) 111235627(faah2)
HCQ: 109508392(faah2) 109532416(faah)
BPEC: 110167803(faah) 110171974(faah2)
MALB: 109964053(faah) 109971428(faah2)
SFM: 108925886(faah2)
CMK: 103177607(faah2) 103182725(faah)
CIN: 100185523
SPU: 575660
APLC: 110981466
DME: Dmel_CG5112(CG5112) Dmel_CG7900(CG7900) Dmel_CG7910(CG7910) Dmel_CG8839(CG8839)
DER: 6546832
DPE: 6591268
DSI: Dsimw501_GD18511(Dsim_GD18511) Dsimw501_GD18512(Dsim_GD18512) Dsimw501_GD21221(Dsim_GD21221) Dsimw501_GD25848(Dsim_GD25848)
DWI: 6643343
API: 100159751
DNX: 107167432
CEL: CELE_B0218.1(faah-1) CELE_B0218.2(faah-2) CELE_Y41C4A.2(faah-6) CELE_Y53F4B.18(Y53F4B.18) CELE_Y56A3A.12(faah-4)
SHX: MS3_00394
ADF: 107334260
SMIN: v1.2.003599.t1(symbB.v1.2.003599.t1) v1.2.008889.t1(symbB.v1.2.008889.t1)
PSOS: POS17_3792
DAL: Dalk_2766
SCL: sce3727
BBAT: Bdt_2627
BBAC: EP01_09700
BEX: A11Q_2195
 » show all
Taxonomy
Reference
1  [PMID:11128635]
  Authors
Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF
  Title
Fatty acid amide hydrolase substrate specificity.
  Journal
Bioorg Med Chem Lett 10:2613-6 (2000)
DOI:10.1016/S0960-894X(00)00528-X
Reference
2  [PMID:9790682]
  Authors
Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF
  Title
Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site  for oligomerization.
  Journal
Biochemistry 37:15177-87 (1998)
DOI:10.1021/bi981733n
Reference
3  [PMID:11352748]
  Authors
Patricelli MP, Cravatt BF
  Title
Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase.
  Journal
Biochemistry 40:6107-15 (2001)
DOI:10.1021/bi002578r
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.99
IUBMB Enzyme Nomenclature: 3.5.1.99
ExPASy - ENZYME nomenclature database: 3.5.1.99
BRENDA, the Enzyme Database: 3.5.1.99

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