KEGG   ENZYME: 3.5.2.19Help
Entry
EC 3.5.2.19                 Enzyme                                 

Name
streptothricin hydrolase;
sttH (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
BRITE hierarchy
Sysname
streptothricin-F hydrolase
Reaction(IUBMB)
streptothricin-F + H2O = streptothricin-F acid [RN:R09657]
Reaction(KEGG)
Substrate
streptothricin F [CPD:C19785];
H2O [CPD:C00001]
Product
streptothricin F acid [CPD:C19786]
Comment
The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid [1]. The enzyme is responsible for streptothricin resistance in Streptomyces albulus and Streptomyces noursei [1,2].
History
EC 3.5.2.19 created 2011
Orthology
K20816  streptothricin hydrolase
Genes
SGR: SGR_517
SFA: Sfla_4024
SBH: SBI_05248
SVE: SVEN_0767
STRP: F750_2699
SFI: SFUL_6857
SALL: SAZ_31715
SVT: SVTN_05300
SLC: SL103_25620
SPRI: SPRI_1189
SNR: SNOUR_11545(sttH)
KFL: Kfla_2808
 » show all
Taxonomy
Reference
1  [PMID:19897889]
  Authors
Maruyama C, Hamano Y
  Title
The biological function of the bacterial isochorismatase-like hydrolase SttH.
  Journal
Biosci Biotechnol Biochem 73:2494-500 (2009)
DOI:10.1271/bbb.90499
  Sequence
Reference
2  [PMID:16641084]
  Authors
Hamano Y, Matsuura N, Kitamura M, Takagi H
  Title
A novel enzyme conferring streptothricin resistance alters the toxicity of streptothricin D from broad-spectrum to bacteria-specific.
  Journal
J Biol Chem 281:16842-8 (2006)
DOI:10.1074/jbc.M602294200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.2.19
IUBMB Enzyme Nomenclature: 3.5.2.19
ExPASy - ENZYME nomenclature database: 3.5.2.19
BRENDA, the Enzyme Database: 3.5.2.19

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