KEGG   ENZYME: 3.5.3.23Help
Entry
EC 3.5.3.23                 Enzyme                                 

Name
N-succinylarginine dihydrolase;
N2-succinylarginine dihydrolase;
arginine succinylhydrolase;
SADH;
AruB;
AstB;
2-N-succinyl-L-arginine iminohydrolase (decarboxylating)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
BRITE hierarchy
Sysname
N2-succinyl-L-arginine iminohydrolase (decarboxylating)
Reaction(IUBMB)
N2-succinyl-L-arginine + 2 H2O = N2-succinyl-L-ornithine + 2 NH3 + CO2 [RN:R04189]
Reaction(KEGG)
Substrate
N2-succinyl-L-arginine [CPD:C03296];
H2O [CPD:C00001]
Product
N2-succinyl-L-ornithine [CPD:C03415];
NH3 [CPD:C00014];
CO2 [CPD:C00011]
Comment
Arginine, N2-acetylarginine and N2-glutamylarginine do not act as substrates [3]. This is the second enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase).
History
EC 3.5.3.23 created 2006
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K01484  succinylarginine dihydrolase
Genes
ECO: b1745(astB)
ECJ: JW1734(astB)
ECD: ECDH10B_1883(astB)
EBW: BWG_1558(astB)
ECOK: ECMDS42_1420(astB)
ECE: Z2777
ECS: ECs2451
ECF: ECH74115_2463(astB)
ETW: ECSP_2313(astB)
ELX: CDCO157_2285
EOJ: ECO26_2520(astB)
EOI: ECO111_2256(astB)
EOH: ECO103_1938(astB)
ECG: E2348C_1873(astB)
EOK: G2583_2191(astB)
ESO: O3O_14380
ESM: O3M_11215
ESL: O3K_11235
ECW: EcE24377A_1967(astB)
ELH: ETEC_1777
EUN: UMNK88_2209(astB)
ECC: c2145
ECP: ECP_1691
ECI: UTI89_C1940(astB)
ECV: APECO1_814(astB)
ECX: EcHS_A1828(astB)
ECM: EcSMS35_1446(astB)
ECY: ECSE_1915
ECR: ECIAI1_1806(astB)
ECQ: ECED1_1947(astB)
ECK: EC55989_1913(astB)
ECT: ECIAI39_1309(astB)
EOC: CE10_2024(astB)
EUM: ECUMN_2034(astB)
ECZ: ECS88_1797(astB)
ELO: EC042_1910(astB)
ESE: ECSF_1606
EBR: ECB_01714(astB)
EBD: ECBD_1900
EKF: KO11_14010(astB)
EAB: ECABU_c20020(astB)
EDJ: ECDH1ME8569_1689(astB)
EIH: ECOK1_1865(astB)
ELW: ECW_m1914(astB)
ELL: WFL_09385(astB)
ELC: i14_1964
ELD: i02_1964
ELP: P12B_c1338(astB)
EBL: ECD_01714(astB)
EBE: B21_01702(astB)
ELF: LF82_0181(astB)
ECOI: ECOPMV1_01843(astB)
ECOJ: P423_09290
ECOS: EC958_1965(astB)
EFE: EFER_1320(astB)
EAL: EAKF1_ch4306(astB)
EMA: C1192_03575(astB)
STY: STY1808(astB)
STT: t1185(astB)
STM: STM1306(astB)
SEO: STM14_1585(astB)
SEY: SL1344_1241(astB)
SEJ: STMUK_1273(astB)
SEB: STM474_1310(astB)
SEF: UMN798_1362(astB)
SENR: STMDT2_12391(astB)
SEND: DT104_12821(astB)
SENI: CY43_06650
SPT: SPA1538(astB)
SEK: SSPA1429
SEC: SCH_1327(astA)
SEH: SeHA_C1433(astB)
SHB: SU5_01925
SEE: SNSL254_A1418(astB)
SEW: SeSA_A1401(astB)
SEA: SeAg_B1867(astB)
SENS: Q786_08725
SED: SeD_A2040(astB)
SEG: SG1810(astB)
SEL: SPUL_1121(astB)
SEGA: SPUCDC_1121(astB)
SET: SEN1737(astB)
SENA: AU38_08990
SENO: AU37_08995
SENV: AU39_09000
SENQ: AU40_10045
SENL: IY59_09195
SEEP: I137_05155
SENE: IA1_06445
SBG: SBG_1159(astB)
SBZ: A464_1261
SFT: NCTC1_01598(astB_1) NCTC1_01599(astB_2)
SSN: SSON_1412
SBO: SBO_1345
SBC: SbBS512_E1991(astB)
SDY: SDY_1532
ENC: ECL_02446
EEC: EcWSU1_01782(astB)
ECLX: LI66_09015
ECLY: LI62_09790
ECLZ: LI64_09080
ECAN: CWI88_13395(astB)
ENF: AKI40_2726(astB)
ESA: ESA_02154
CSK: ES15_2304(astB)
CTU: CTU_18190(astB)
KPN: KPN_01224(astB) KPN_01496
KPU: KP1_2254(astB) KP1_2502
KPT: VK055_1013(astB) VK055_1234(astB2)
KPE: KPK_2965 KPK_3219(astB)
KPR: KPR_2271(astB) KPR_2847(astB)
KPX: PMK1_03603(astB_1) PMK1_03814(astB_2)
KPNK: BN49_2359(astB) BN49_2558(astB2)
KOX: KOX_18155
KOE: A225_2487
EAE: EAE_20390
EAR: CCG29802
KQV: B8P98_15120(astB) B8P98_16220(astB)
CKO: CKO_01771
CRO: ROD_13121(astB)
CBRA: A6J81_02680(astB)
CWE: CO701_11750(astB)
CYO: CD187_13615(astB)
CAMA: F384_05930
CAF: AL524_16390(astB)
CIF: AL515_10740(astB)
CFAR: CI104_11795(astB)
CIR: C2U53_21000(astB)
CIE: AN232_19370(astB)
RAO: DSD31_14040(astB) DSD31_15125(astB)
ICP: BAH83495.1(astB)
LEI: C2U54_14575(astB)
LEH: C3F35_02195(astB)
LNI: CWR52_03160(astB)
LEW: DAI21_17740(astB)
EBF: D782_2552
EBC: C2U52_20690(astB)
PSTS: E05_12100
YPE: YPO1965(astB)
YPK: y2346
YPA: YPA_1347
YPM: YP_1710(astB)
YPG: YpAngola_A2517(astB)
YPD: YPD4_1730(astB)
YPX: YPD8_1818(astB)
YPW: CH59_3763(astB)
YPV: BZ15_1576(astB)
YPL: CH46_3149(astB)
YPS: YPTB1962(astB)
YPO: BZ17_507(astB)
YPI: YpsIP31758_2118(astB)
YPY: YPK_2226
YPB: YPTS_2014
YPQ: DJ40_351(astB)
YPU: BZ21_1235(astB)
YPR: BZ20_153(astB)
YPC: BZ23_1519(astB)
YPF: BZ19_1310(astB)
YEN: YE2466(astB)
YEL: LC20_02349(astB)
YEW: CH47_1814(astB)
YET: CH48_3485(astB)
YEE: YE5303_21261(astB)
YAL: AT01_645(astB)
YFR: AW19_985(astB)
YIN: CH53_3736(astB)
YKR: CH54_678(astB)
YRO: CH64_341(astB)
YRU: BD65_124(astB)
YMA: DA391_12770(astB)
SPE: Spro_2841
SRL: SOD_c26840(astB)
SPLY: Q5A_014890(astB)
SMW: SMWW4_v1c28590(astB)
SMAR: SM39_2323(astB)
SMAC: SMDB11_2117(astB)
SERF: L085_14495
SERA: Ser39006_004535(astB)
SERM: CLM71_05045(astB) CLM71_13750(astB)
RAA: Q7S_08175
LBQ: CKQ53_11255(astB)
ETA: ETA_18560(astB)
EPY: EpC_19440(astB)
EPR: EPYR_02101(astB)
EAM: EAMY_1631(astB)
EAY: EAM_1609(astB)
EBI: EbC_18610(astB)
ERJ: EJP617_27740(astB)
EGE: EM595_1638(astB)
EPE: CI789_09240(astB)
PAM: PANA_1677(astB)
PLF: PANA5342_2537(astB)
PAJ: PAJ_1027(astB)
PVA: Pvag_1117(astB)
PAGG: AL522_12840(astB)
PCK: BMSBPS_p0002(astB)
PSTW: DSJ_12770
PGZ: C2E15_09530(astB)
PCD: C2E16_09620(astB)
TPTY: NCTC11468_01715(astB)
PLU: plu3107(astB)
PAY: PAU_01500(astB)
XBO: XBJ1_2939(astB)
XBV: XBW1_3144(astB)
XDO: XDD1_2673(astB)
XPO: XPG1_1217(astB)
PSHI: SAMEA2665130_1893(astB)
VFL: AL536_06435(astB)
VFI: VF_A0847(astB)
VFM: VFMJ11_A0979(astB)
VSA: VSAL_II0073(astB)
AWD: AWOD_II_0964(astB)
PPR: PBPRB0591(ECS2451)
PMAI: CF386_06410(astB)
PAE: PA0899(aruB)
PAEV: N297_927(astB)
PAEI: N296_927(astB)
PAU: PA14_52660(aruB)
PAP: PSPA7_4616(astB)
PAG: PLES_44171(aruB)
PAF: PAM18_4140(aruB)
PNC: NCGM2_1677(aruB)
PAEB: NCGM1900_1823(aruB)
PAEP: PA1S_21945
PAEM: U769_21315
PAEL: T223_22580
PAEU: BN889_00939(aruB)
PAEG: AI22_11995
PAEC: M802_923(astB)
PAEO: M801_927(astB)
PMY: Pmen_2907
PMK: MDS_1751
PRE: PCA10_42380(astB)
PPSE: BN5_1494(astB)
PCQ: PcP3B5_15750(astB)
PPU: PP_4477(astB)
PPF: Pput_1438
PPT: PPS_3822
PPB: PPUBIRD1_1425(astB)
PPI: YSA_07947
PPX: T1E_2403
PPUH: B479_18995
PPUT: L483_24460
PPUN: PP4_13430(astB)
PPUD: DW66_4256
PMON: X969_18400
PMOT: X970_18035
PST: PSPTO_1836(astB)
PSB: Psyr_3561
PSYR: N018_07615
PSP: PSPPH_3517(astB)
PAMG: BKM19_021050(astB)
PAVL: BKM03_20510(astB)
PFL: PFL_4511(astB)
PPRC: PFLCHA0_c45830(astB)
PPRO: PPC_4615
PFO: Pfl01_4281(astB)
PFS: PFLU_4753
PFC: PflA506_4067(astB)
PFW: PF1751_v1c42580(astB)
PFB: VO64_1603
PMAN: OU5_5005(astB)
PEN: PSEEN3878(aruB)
PPUU: PputUW4_04171(astB)
PKC: PKB_1596(astb1) PKB_1597(astb3)
PSES: PSCI_0162
PSEM: TO66_23560
PSEC: CCOS191_1438(astB)
PSOS: POS17_4577
PANR: A7J50_4516
PSET: THL1_4285
PSIL: PMA3_05640
ACB: A1S_3129
ABM: ABSDF0358(astB)
ABY: ABAYE0355(astB)
ABN: AB57_3584
ABB: ABBFA_000380(astB)
ABX: ABK1_3379
ABH: M3Q_3560
ABAD: ABD1_30170(astB)
ABAZ: P795_1755
ABAU: IX87_12410
ABAA: IX88_00420
ACC: BDGL_002594(astB)
ACI: ACIAD1288(astB)
ARJ: DOM24_09790(astB)
SON: SO_2706(astB)
SDN: Sden_2329
SFR: Sfri_2479
SAZ: Sama_1321
SBL: Sbal_2497
SLO: Shew_2225
SSE: Ssed_2842
SPL: Spea_1534
SHL: Shal_1604
SWD: Swoo_1802
SWP: swp_1743
SVO: SVI_2771(astB)
SHF: CEQ32_02920(astB)
SPSW: Sps_01661
SBJ: CF168_12085(astB)
SMAV: CFF01_08100(astB)
SHEW: CKQ84_21340(astB)
ILO: IL1011(astB)
IPI: CEW91_08450(astB)
IDI: CWC33_01320(astB)
IDT: C5610_03740(astB)
PHA: PSHAb0177(astB)
PAT: Patl_2357
PSM: PSM_B0188(astB)
PSEO: OM33_17205
PTN: PTRA_b0249(astB)
PPIS: B1L02_09290(astB) B1L02_18245(astB)
PEA: PESP_b0302(astB)
PSPO: PSPO_b0397(astB)
PART: PARC_b0217(astB)
PTU: PTUN_a1655(astB)
PNG: PNIG_b0262(astB)
PTD: PTET_b0257(astB)
PSEN: PNC201_09625(astB)
MAQ: Maqu_3315
MHC: MARHY3160(astB)
MAD: HP15_3038(astB)
MBS: MRBBS_3286(astB)
MARA: D0851_09195(astB)
AMAL: I607_07905
AMAE: I876_08170
AMAO: I634_08275
AMAD: I636_08715
AMAI: I635_08985
AMAG: I533_08215
AMAC: MASE_07780
AAUS: EP12_08655
GNI: GNIT_1719(astB)
GPS: C427_2752
SALH: HMF8227_01295(astB)
SALM: D0Y50_07845(astB)
FBL: Fbal_2522
TTU: TERTU_2361(astB)
LPN: lpg1708(astB)
LPO: LPO_1742(astB)
LPM: LP6_1685(astB)
LPF: lpl1667(astB)
LPP: lpp1673(astB)
LPC: LPC_1137(astB)
LPA: lpa_02463(astB)
LPE: lp12_1646
LLO: LLO_1711(astB)
LFA: LFA_1722(astB)
LHA: LHA_1448(astB)
LCD: clem_07645(astB)
LSH: CAB17_13565(astB)
LLG: 44548918_01288(astB)
TMC: LMI_1890(astB)
HCH: HCH_01951(astB)
CSA: Csal_2804
HEL: HELO_1419(aruB)
HAM: HALO1441
HCO: LOKO_00286(astB)
HHH: CLM76_00940(astB)
HBE: BEI_0490(astB)
HAF: C8233_14275(astB)
KKO: Kkor_0785
KGE: TQ33_0634
KPD: CW740_03580(astB)
BSAN: CHH28_00680(astB)
AHA: AHA_3105(astB)
ASA: ASA_3112(astB)
AVR: B565_1037
AMED: B224_1104
ASR: WL1483_295(astB)
ADH: CK627_10235(astB)
ACAV: VI35_05785(astB)
AEM: CK911_02070(astB)
AEA: C2U39_06395(astB)
ARV: C7N77_18915(astB)
OCE: GU3_11125
SALN: SALB1_0837
CVI: CV_1500(aruB)
CHRO: CXB49_15015(astB)
CHRI: DK842_15050(astB)
PSE: NH8B_2839
CNC: CNE_BB1p01210(astB)
BMA: BMA0595(astB)
BMV: BMASAVP1_A2421(astB)
BML: BMA10229_A2870(astB)
BMN: BMA10247_1732(astB)
BMAL: DM55_1969(astB)
BMAE: DM78_1187(astB)
BMAQ: DM76_1944(astB)
BMAI: DM57_2610
BMAF: DM51_381(astB)
BMAZ: BM44_1458(astB)
BMAB: BM45_1021(astB)
BPS: BPSL2386(astB)
BPM: BURPS1710b_2842(astB)
BPL: BURPS1106A_2781(astB)
BPD: BURPS668_2723(astB)
BPR: GBP346_A2903(astB)
BPSE: BDL_3104(astB)
BPSM: BBQ_926(astB)
BPSU: BBN_1053(astB)
BPSD: BBX_1505(astB)
BPZ: BP1026B_I0938(astB)
BPK: BBK_2570(astB)
BPSH: DR55_2135(astB)
BPSA: BBU_3175(astB)
BPSO: X996_1778(astB)
BUT: X994_51(astB)
BTE: BTH_I1779(astB)
BTQ: BTQ_2136(astB)
BTJ: BTJ_175(astB)
BTZ: BTL_1470(astB)
BTD: BTI_1248(astB)
BTV: BTHA_1574(astB)
BTHE: BTN_3305(astB)
BTHM: BTRA_1696(astB)
BTHA: DR62_75
BTHL: BG87_1683(astB)
BOK: DM82_2000(astB)
BOC: BG90_2712(astB)
BVE: AK36_2745(astB)
BCN: Bcen_0705
BCJ: BCAL1063(astB)
BCEN: DM39_1031(astB)
BCEW: DM40_1848(astB)
BCEO: I35_1055(astB)
BAM: Bamb_1065
BMU: Bmul_2120
BMJ: BMULJ_01124(astB)
BMK: DM80_453(astB)
BMUL: NP80_1294(astB)
BCT: GEM_2330
BCED: DM42_538(astB)
BDL: AK34_1962(astB)
BCON: NL30_09720
BUB: BW23_547(astB)
BLAT: WK25_05645
BTEI: WS51_16185
BSEM: WJ12_05810
BPSL: WS57_23515
BMEC: WJ16_05585
BSTG: WT74_05940
BGU: KS03_1946(astB)
BGO: BM43_2492(astB)
BUK: MYA_1080
BUO: BRPE64_ACDS10880(astB)
BUE: BRPE67_ACDS10010(astB)
BUL: BW21_1397(astB)
BGP: BGL_1c10470(astB)
BXE: Bxe_A2919
BXB: DR64_601(astB)
BPH: Bphy_1783
BFN: OI25_159(astB)
PARB: CJU94_17240(astB)
PHS: C2L64_10535(astB)
PTER: C2L65_09695(astB)
PGP: CUJ91_06730(astB)
PPNO: DA70_03200
PPNM: LV28_03130
PPUL: RO07_22010
PSPU: NA29_14895
PAPI: SG18_21280
PLG: NCTC10937_03868(astB)
JAG: GJA_311(astB)
JSV: CNX70_27480(astB)
MASZ: C9I28_03355(astB)
MTIM: DIR46_15375(astB)
MASY: DPH57_18615(astB)
NLC: EBAPG3_010815(astB)
MXA: MXAN_1056(astB)
CCX: COCOR_00993(astB)
SUR: STAUR_1607(astB)
MSL: Msil_0626
CAK: Caul_2204
CSE: Cseg_2600
BVC: CEP68_02680(astB)
HNE: HNE_1993(astB)
HBA: Hbal_1561
ZMO: ZMO1172
ZMN: Za10_0156
ZMM: Zmob_0157
ZMB: ZZ6_0159
ZMI: ZCP4_0161
ZMC: A265_00161(astB)
ZMR: A254_00161(astB)
NAR: Saro_0882
SAL: Sala_1941
SPHK: SKP52_15235(astB)
SPHP: LH20_08745
SMAZ: LH19_16605
SGI: SGRAN_2747(astB)
SPHU: SPPYR_0848(astB)
SWI: Swit_0527
SPHD: HY78_24060
SPHM: G432_01875
STAX: MC45_02400
SPHI: TS85_06705
SSAN: NX02_13135
SPKC: KC8_03480
SJP: SJA_C1-17620(astB)
SSY: SLG_09910(astB)
SPMI: K663_08035
SPHB: EP837_00113(astB)
SPHR: BSY17_2904
SINB: SIDU_05545
SPHT: K426_13525
SFLA: SPHFLASMR4Y_01347(astB)
BLAS: BSY18_1887
ELI: ELI_08925
AAY: WYH_01131(astB)
ANH: A6F65_02108(astB)
ADO: A6F68_01759(astB)
TXI: TH3_12765
THAC: CSC3H3_12310(astB)
PNL: PNK_1547(astB)
PUV: PUV_12070(astB)
WCH: wcw_0829(astB)
PIR: VN12_08290(astB)
PHM: PSMK_17570(astB)
 » show all
Taxonomy
Reference
1  [PMID:9696779]
  Authors
Schneider BL, Kiupakis AK, Reitzer LJ.
  Title
Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli.
  Journal
J Bacteriol 180:4278-86 (1998)
  Sequence
[eco:b1745]
Reference
2  [PMID:15703173]
  Authors
Tocilj A, Schrag JD, Li Y, Schneider BL, Reitzer L, Matte A, Cygler M.
  Title
Crystal structure of N-succinylarginine dihydrolase AstB, bound to substrate and product, an enzyme from the arginine catabolic pathway of Escherichia coli.
  Journal
J Biol Chem 280:15800-8 (2005)
DOI:10.1074/jbc.M413833200
  Sequence
[eco:b1745]
Reference
3  [PMID:2865249]
  Authors
Vander Wauven C, Stalon V.
  Title
Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia.
  Journal
J Bacteriol 164:882-6 (1985)
Reference
4  [PMID:3534538]
  Authors
Cunin R, Glansdorff N, Pierard A, Stalon V.
  Title
Biosynthesis and metabolism of arginine in bacteria.
  Journal
Microbiol Rev 50:314-52 (1986)
Reference
5  [PMID:9393691]
  Authors
Itoh Y.
  Title
Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa.
  Journal
J Bacteriol 179:7280-90 (1997)
DOI:10.1128/JB.179.23.7280-7290.1997
  Sequence
[pae:PA0899]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.3.23
IUBMB Enzyme Nomenclature: 3.5.3.23
ExPASy - ENZYME nomenclature database: 3.5.3.23
BRENDA, the Enzyme Database: 3.5.3.23

DBGET integrated database retrieval system