KEGG   ENZYME: 3.5.3.3Help
Entry
EC 3.5.3.3                  Enzyme                                 

Name
creatinase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
BRITE hierarchy
Sysname
creatine amidinohydrolase
Reaction(IUBMB)
creatine + H2O = sarcosine + urea [RN:R01566]
Reaction(KEGG)
Substrate
creatine [CPD:C00300];
H2O [CPD:C00001]
Product
sarcosine [CPD:C00213];
urea [CPD:C00086]
History
EC 3.5.3.3 created 1961
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K08688  creatinase
Genes
KOE: A225_0582
KOM: HR38_27865
KQU: AVR78_26185
PRE: PCA10_04400
PPSE: BN5_0137(pepQ)
PCQ: PcP3B5_01400
PPU: PP_3667(creA)
PPF: Pput_2062
PPG: PputGB1_2232
PPW: PputW619_2236 PputW619_3269
PPT: PPS_2272
PPI: YSA_09478
PPX: T1E_1754
PPUH: B479_11675
PPUN: PP4_21260
PPUD: DW66_2531
PMON: X969_09705
PMOT: X970_09365
PFL: PFL_5299(pepQ)
PPRO: PPC_5277(pepQ)
PSZ: PSTAB_0117(pepQ)
PKC: PKB_0197
PSOS: POS17_5264
PSET: THL1_383
PSIL: PMA3_12795
OCE: GU3_07685
PSE: NH8B_1341
BCEN: DM39_6465
BPSL: WS57_17245
BPH: Bphy_6284
SHZ: shn_25500
OAH: DR92_4431
MMED: Mame_02389
SIL: SPO3327
RSP: RSP_1752
RCP: RCAP_rcc00431(creA)
JAN: Jann_2612
RDE: RD1_0929(cln)
DSH: Dshi_2126
PGD: Gal_00468
OTM: OSB_23980
MALG: MALG_03308
RSU: NHU_03374
RHC: RGUI_0492
PUB: SAR11_0687(pepQ)
EAC: EAL2_808p07360(creA)
CTER: A606_03785
ROP: ROP_15090
ART: Arth_3728
ARM: ART_1482
AAU: AAur_3822
ACH: Achl_3303
KRH: KRH_03000
MPH: MLP_20240
MMAR: MODMU_3069
RXY: Rxyl_0461
 » show all
Taxonomy
Reference
1  [PMID:14791411]
  Authors
ROCHE J, LACOMBE G, GIRARD H.
  Title
[On the specificity of certain bacterial deguanidases generating urea and on arginindihydrolase.]
  Journal
Biochim Biophys Acta 6:210-6 (1950)
Reference
2  [PMID:8443]
  Authors
Yoshimoto T, Oka I, Tsuru D.
  Title
Purification, crystallization, and some properties of creatine amidinohydrolase from Pseudomonas putida.
  Journal
J Biochem (Tokyo) 79:1381-3 (1976)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.3.3
IUBMB Enzyme Nomenclature: 3.5.3.3
ExPASy - ENZYME nomenclature database: 3.5.3.3
BRENDA, the Enzyme Database: 3.5.3.3
CAS: 37340-58-2

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