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Entry
EC 3.5.4.27                 Enzyme                                 

Name
methenyltetrahydromethanopterin cyclohydrolase;
5,10-methenyltetrahydromethanopterin cyclohydrolase;
N5,N10-methenyltetrahydromethanopterin cyclohydrolase;
methenyl-H4MPT cyclohydrolase;
5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
5,10-methenyltetrahydromethanopterin 10-hydrolase (ring-opening)
Reaction(IUBMB)
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin [RN:R03464]
Reaction(KEGG)
Substrate
5,10-methenyl-5,6,7,8-tetrahydromethanopterin [CPD:C04330];
H2O [CPD:C00001]
Product
5-formyl-5,6,7,8-tetrahydromethanopterin [CPD:C01274]
Comment
Methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum.
History
EC 3.5.4.27 created 1989
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K01499  methenyltetrahydromethanopterin cyclohydrolase
Genes
MCA: MCA2863
MMT: Metme_2265
MDN: JT25_019335
MDH: AYM39_08540
MKO: MKLM6_1778
MAH: MEALZ_2425(mch)
MPSY: CEK71_15610
MEJ: Q7A_44
MEC: Q7C_1772
BLEP: AL038_01000
NHL: Nhal_3876
BXE: Bxe_B2433(mch)
BXB: DR64_4761(mch)
VPD: VAPA_1c31460(mch)
MPT: Mpe_A2609
LCH: Lcho_3150
RGE: RGE_40250(mch)
METR: BSY238_3292(mch)
MFA: Mfla_1658
MMB: Mmol_1344
MEH: M301_1554
MEP: MPQ_1565
MBAC: BN1209_0747(mch)
RGA: RGR602_PC01568(mch)
XAU: Xaut_1788
SNO: Snov_0750
MEX: Mext_1831
MEA: Mex_1p1763(mch)
MDI: METDI2515(mch)
MCH: Mchl_2166
MPO: Mpop_1782
MET: M446_5780
MNO: Mnod_6004
MOR: MOC_0685(mch)
META: Y590_08770
MAQU: Maq22A_c16475(mch)
MSL: Msil_2387
HDN: Hden_1477
HMC: HYPMC_1627(mch)
FIL: BN1229_v1_0586(mch)
FIY: BN1229_v1_0588(mch)
MSC: BN69_1353
MCG: GL4_1786
HDI: HDIA_2312(mch)
ALI: AZOLI_p10687(mch1) AZOLI_p10889(mch2)
ABS: AZOBR_p270082(mch)
CBT: CLH_1638(mch)
CAP: CLDAP_00590(mch)
RBA: RB6759(mch)
PSL: Psta_3184
PIR: VN12_11975(mch)
PLM: Plim_2586
PLS: VT03_28970(mch)
PLH: VT85_05465(mch)
FMR: Fuma_00366(mch)
GES: VT84_09780(mch)
GOG: C1280_06325(mch)
IPA: Isop_0325
SACI: Sinac_1236
PBOR: BSF38_00163(mch)
MOX: DAMO_0461(mch)
MJA: MJ_1636
MMP: MMP1191(mch)
MMD: GYY_06780
MAE: Maeo_0441
MVO: Mvol_0378
MTH: MTH_773
MMG: MTBMA_c11690(mch)
METC: MTCT_0692
MWO: MWSIV6_1147(mch)
METE: tca_00740(mch)
MST: Msp_1238(mch)
MSI: Msm_1723
MRU: mru_1619(mch)
MEB: Abm4_1203(mch)
MMIL: sm9_1330(mch)
MEYE: TL18_04360
MOL: YLM1_1103
METH: MBMB1_0537(mch)
MFC: BRM9_1751(mch)
MFI: DSM1535_2390(mch)
MCUB: MCBB_0462(mch)
MFV: Mfer_0254
MKA: MK0625(mch)
AFU: AF_1935
FPL: Ferp_0606
GAC: GACE_0343
GAH: GAH_01155
MAC: MA_1710(mch)
MBAR: MSBR2_0727
MBAK: MSBR3_0457
MMA: MM_2653
MMAC: MSMAC_1059
METM: MSMTP_2066
MTHE: MSTHC_0286
MTHR: MSTHT_0435
MHOR: MSHOH_2598
MBU: Mbur_0653(mch)
MMET: MCMEM_0808
MMH: Mmah_1138
MPY: Mpsy_3012
MTP: Mthe_0252
MCJ: MCON_1290(mch)
MHI: Mhar_2174
MLA: Mlab_0399
MBG: BN140_0141(mch1) BN140_1778(mch3)
MEMA: MMAB1_2292(mch)
MPI: Mpet_0065
MBN: Mboo_0680
MPL: Mpal_2022
MPD: MCP_1132(mch-1) MCP_1888(mch-2)
MEZ: Mtc_1063(mch-1) Mtc_1978(mch-2)
RCI: LRC191(mch-1) RCIX2742(mch-2)
HAL: VNG_1686G(mch)
HSL: OE_3383R(mch)
HHB: Hhub_3179(mch)
HALH: HTSR_0323
HHSR: HSR6_0309(mch)
HMA: rrnAC1616(mch)
HHI: HAH_2159(mch)
NPH: NP_2634A(mch)
NMO: Nmlp_2018(mch)
HUT: Huta_1145
HTI: HTIA_1038
HMU: Hmuk_1816
HWA: HQ_2798A(mch)
HWC: Hqrw_3170(mch)
HVO: HVO_2573
HME: HFX_2599
HLA: Hlac_1693
HTU: Htur_2210
NMG: Nmag_0205(mch)
NAT: NJ7G_2078
SALI: L593_12155
BARC: AOA65_2050(mch)
LOKI: Lokiarch_00580(mch_1) Lokiarch_17800(mch_2)
 » show all
Taxonomy
Reference
1  [PMID:4062290]
  Authors
Donnelly MI, Escalante-Semerena JC, Rinehart KL Jr, Wolfe RS.
  Title
Methenyl-tetrahydromethanopterin cyclohydrolase in cell extracts of Methanobacterium.
  Journal
Arch Biochem Biophys 242:430-9 (1985)
DOI:10.1016/0003-9861(85)90227-9
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.27
IUBMB Enzyme Nomenclature: 3.5.4.27
ExPASy - ENZYME nomenclature database: 3.5.4.27
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.4.27
BRENDA, the Enzyme Database: 3.5.4.27
CAS: 99533-50-3

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