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Entry
EC 3.5.4.29                 Enzyme                                 

Name
GTP cyclohydrolase IIa
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
GTP 8,9-hydrolase (phosphate-forming)
Reaction(IUBMB)
GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate [RN:R07306]
Reaction(KEGG)
Substrate
GTP [CPD:C00044];
H2O [CPD:C00001]
Product
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C15563];
phosphate [CPD:C00009]
Comment
Requires Mg2+. This enzyme catalyses the hydrolysis of the imidazole ring of guanosine 5'-triphosphate, N7-methylguanosine 5'-triphosphate or inosine 5'-triphosphate. Xanthosine 5'-triphosphate and ATP are not substrates. It also catalyses the hydrolysis of diphosphate to form two equivalents of phosphate. Unlike GTP cyclohydrolase II (EC 3.5.4.25), this enzyme does not release formate, but does hydrolyse the diphosphate from GTP to phosphate.
History
EC 3.5.4.29 created 2003, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K08096  GTP cyclohydrolase IIa
Genes
MJA: MJ_0145
MFE: Mefer_0498
MVU: Metvu_1460
MFS: MFS40622_0137
MIF: Metin_0291
MJH: JH146_0012
MIG: Metig_0265
MMP: MMP0405(gch3)
MMQ: MmarC5_1233
MMX: MmarC6_0505
MMD: GYY_02095
MAE: Maeo_0818
MVO: Mvol_1650
MTH: MTH_1017
MMG: MTBMA_c13990(gch3)
METC: MTCT_0925
MWO: MWSIV6_1403(gch3)
METE: tca_00978
MST: Msp_1404(gch3)
MSI: Msm_0973
MRU: mru_1845(arfA)
MEB: Abm4_1486(arfA)
MMIL: sm9_1936(arfA)
MEYE: TL18_09135
MOL: YLM1_1302
METH: MBMB1_0199(gch3)
MFC: BRM9_2101(arfA)
MFI: DSM1535_1580(gch3)
MCUB: MCBB_0214(gch3)
MFV: Mfer_0318
HSL: OE_2472F(gch3a) OE_2492F(gch3b)
HHB: Hhub_2223(gch3)
HALH: HTSR_0917
HHSR: HSR6_0931(gch)
HSU: HLASF_1555(gch)
HSF: HLASA_1542(gch)
HMA: rrnAC0115
HHI: HAH_0868
NPH: NP_4142A(arfA)
NMO: Nmlp_2421(gch3)
HUT: Huta_1998
HMU: Hmuk_2633
HWA: HQ_2427A(arfA)
HWC: Hqrw_2717(arfA)
HVO: HVO_1284(gch3)
HME: HFX_1350
HLA: Hlac_2188
HTU: Htur_1598
NMG: Nmag_3329(gch3)
SALI: L593_10970
ACJ: ACAM_0863
SMR: Smar_0486
IHO: Igni_1352
IIS: EYM_01970
STO: STK_03950
SSO: SSO0399
SOL: Ssol_1377
SSOA: SULA_1423
SSOL: SULB_1424
SSOF: SULC_1422
SAI: Saci_0819
SID: M164_1751
SII: LD85_1961
SIH: SiH_1679
SIR: SiRe_1600
SIC: SiL_1592
MSE: Msed_0049
MCN: Mcup_0048
AHO: Ahos_0727
PAI: PAE2984
PIS: Pisl_0384
PCL: Pcal_1123
PAS: Pars_1351
PYR: P186_1548
POG: Pogu_0863
TNE: Tneu_1743
TUZ: TUZN_0675
TTN: TTX_1009
VDI: Vdis_0343
VMO: VMUT_1288
ASC: ASAC_0813
ACIA: SE86_05725
NMR: Nmar_1614
NID: NPIRD3C_0439(gch)
NIN: NADRNF5_0270(gch)
NCT: NMSP_1555(gch3)
NGA: Ngar_c32640(gch3)
NVN: NVIE_021890(gch)
NEV: NTE_03547
NCV: NCAV_0049(gch)
NBV: T478_1328
NDV: NDEV_1968(gch)
 » show all
Taxonomy
Reference
1  [PMID:12475257]
  Authors
Graham DE, Xu H, White RH.
  Title
A member of a new class of GTP cyclohydrolases produces formylaminopyrimidine nucleotide monophosphates.
  Journal
Biochemistry 41:15074-84 (2002)
DOI:10.1021/bi0268798
  Sequence
[mja:MJ_0145]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.29
IUBMB Enzyme Nomenclature: 3.5.4.29
ExPASy - ENZYME nomenclature database: 3.5.4.29
BRENDA, the Enzyme Database: 3.5.4.29

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