KEGG   ENZYME: 3.5.4.37Help
Entry
EC 3.5.4.37                 Enzyme                                 

Name
double-stranded RNA adenine deaminase;
ADAR;
double-stranded RNA adenosine deaminase;
dsRAD;
dsRNA adenosine deaminase;
DRADA1;
double-stranded RNA-specific adenosine deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
double-stranded RNA adenine aminohydrolase
Reaction(IUBMB)
adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3
Substrate
adenine in double-stranded RNA;
H2O [CPD:C00001]
Product
hypoxanthine in double-stranded RNA;
NH3 [CPD:C00014]
Comment
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4].
History
EC 3.5.4.37 created 2013
Orthology
K12968  double-stranded RNA-specific adenosine deaminase
Genes
HSA: 103(ADAR)
PTR: 457349(ADAR)
PPS: 100988581(ADAR)
GGO: 101134621(ADAR)
PON: 100457633(ADAR)
NLE: 100607902(ADAR)
MCC: 718759(ADAR)
MCF: 101926284(ADAR)
CSAB: 103223917(ADAR)
RRO: 104663489(ADAR)
CJC: 100386367(ADAR)
SBQ: 101031414(ADAR)
MMU: 56417(Adar)
RNO: 81635(Adar)
CGE: 100760578(Adar)
NGI: 103751329(Adar)
HGL: 101722209(Adar)
CCAN: 109688036(Adar)
OCU: 100346984(ADAR)
TUP: 102485185(ADAR)
CFA: 100855668(ADAR)
AML: 100470274(ADAR)
UMR: 103668714(ADAR)
ORO: 101367365(ADAR)
FCA: 101084681(ADAR)
PTG: 102950196(ADAR)
AJU: 106988378(ADAR)
BTA: 505134(ADAR)
BOM: 102267031(ADAR)
BIU: 109554054(ADAR)
PHD: 102343559(ADAR)
CHX: 102172585(ADAR)
OAS: 101104366(ADAR)
SSC: 100523784(ADAR)
CFR: 102512737(ADAR)
CDK: 105089080(ADAR)
BACU: 103018582(ADAR)
LVE: 103077270(ADAR)
OOR: 101278697(ADAR)
ECB: 100056984(ADAR)
EPZ: 103555415(ADAR)
EAI: 106828524(ADAR)
MYB: 102242753(ADAR)
MYD: 102754391(ADAR)
HAI: 109393401(ADAR)
RSS: 109434689(ADAR)
PALE: 102895875(ADAR)
LAV: 100665054(ADAR)
TMU: 101360020
MDO: 100020840(ADAR)
SHR: 100925968(ADAR)
GGA: 769675(ADAR)
MGP: 100541796(ADAR)
CJO: 107324489(ADAR)
APLA: 101796198(ADAR)
ACYG: 106048529(ADAR)
TGU: 100220215(ADAR)
GFR: 102033970(ADAR)
FAB: 101806137(ADAR)
PHI: 102105960(ADAR)
PMAJ: 107214561(ADAR)
CCAE: 111939463(ADAR)
CCW: 104698661(ADAR)
FPG: 101910869(ADAR)
FCH: 102049629(ADAR)
CLV: 102086506(ADAR)
EGZ: 104127874(ADAR)
AAM: 106483717(ADAR)
ASN: 102377665(ADAR)
AMJ: 102575445(ADAR)
PSS: 102449470(ADAR)
CMY: 102941128(ADAR)
CPIC: 101936755(ADAR)
PVT: 110081003(ADAR)
PBI: 103050667(ADAR)
GJA: 107117082(ADAR)
XLA: 394279(adar-a) 397992(adar.S)
XTR: 100493195(adar)
NPR: 108798342(ADAR)
DRE: 58119(adar)
IPU: 108265537(adar)
AMEX: 103023414(adar)
TRU: 101073967(adar)
LCO: 104922500(adar)
NCC: 104958853(adar)
MZE: 101475397(adar)
OLA: 101155879(adar)
XMA: 102217978(adar)
PRET: 103478179(adar)
NFU: 107374479(adar) 107379542
KMR: 108241070(adar)
CSEM: 103388211(adar) 103388233
LCF: 108885934(adar)
SDU: 111230122(adar)
HCQ: 109521078(adar)
MALB: 109964118(adar)
SASA: 106573969 106605901(adar)
OTW: 112238838
ELS: 105024448(adar)
SFM: 108925759(adar)
LCM: 102360746(ADAR)
CIN: 100183336
SPU: 584058
CEL: CELE_T20H4.4(adr-2)
CBR: CBG24155(Cbr-adr-2)
OBI: 106871755
SMIN: v1.2.029917.t2(symbB.v1.2.029917.t2)
 » show all
Taxonomy
Reference
1  [PMID:8144588]
  Authors
Hough RF, Bass BL
  Title
Purification of the Xenopus laevis double-stranded RNA adenosine deaminase.
  Journal
J Biol Chem 269:9933-9 (1994)
Reference
2  [PMID:9614652]
  Authors
O'Connell MA, Gerber A, Keegan LP
  Title
Purification of native and recombinant double-stranded RNA-specific adenosine deaminases.
  Journal
Methods 15:51-62 (1998)
DOI:10.1006/meth.1998.0605
Reference
3  [PMID:11421361]
  Authors
Wong SK, Sato S, Lazinski DW
  Title
Substrate recognition by ADAR1 and ADAR2.
  Journal
RNA 7:846-58 (2001)
Reference
4  [PMID:16141067]
  Authors
Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL
  Title
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
  Journal
Science 309:1534-9 (2005)
DOI:10.1126/science.1113150
  Sequence
[hsa:104]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.37
IUBMB Enzyme Nomenclature: 3.5.4.37
ExPASy - ENZYME nomenclature database: 3.5.4.37
BRENDA, the Enzyme Database: 3.5.4.37

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