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Entry
EC 3.5.4.38                 Enzyme                                 

Name
single-stranded DNA cytosine deaminase;
AID;
activation-induced deaminase;
AICDA (gene name);
activation-induced cytidine deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
single-stranded DNA cytosine aminohydrolase
Reaction(IUBMB)
cytosine in single-stranded DNA + H2O = uracil in single-stranded DNA + NH3
Substrate
cytosine in single-stranded DNA;
H2O [CPD:C00001]
Product
uracil in single-stranded DNA;
NH3 [CPD:C00014]
Comment
The enzyme exclusively catalyses deamination of cytosine in single-stranded DNA. It preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G) [2]. The enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences.
History
EC 3.5.4.38 created 2013
Orthology
K10989  activation-induced cytidine deaminase
Genes
HSA: 57379(AICDA)
PTR: 473404(AICDA)
PPS: 100973347(AICDA)
GGO: 101135489(AICDA)
PON: 100439396(AICDA)
NLE: 100592218(AICDA)
MCC: 716378(AICDA)
MCF: 102122751(AICDA)
CSAB: 103218532(AICDA)
RRO: 104672844(AICDA)
RBB: 108543657(AICDA)
CJC: 100387865(AICDA)
SBQ: 101034094(AICDA)
MMU: 11628(Aicda)
RNO: 399679(Aicda)
CGE: 100689250(Aicda)
NGI: 103727567(Aicda)
HGL: 101723465(Aicda)
CCAN: 109680708(Aicda)
OCU: 100008969(AICDA)
TUP: 102476438(AICDA)
CFA: 442983(AICDA)
AML: 100474338(AICDA)
UMR: 103669168(AICDA)
ORO: 101375110(AICDA)
FCA: 101101143(AICDA)
PTG: 102950698(AICDA)
AJU: 106965426(AICDA)
BTA: 539888(AICDA)
BOM: 102271255(AICDA)
BIU: 109558588(AICDA)
PHD: 102323202(AICDA)
CHX: 102181572(AICDA)
OAS: 101103056(AICDA)
SSC: 100526050(AICDA)
CFR: 102517000(AICDA)
CDK: 105098237(AICDA)
BACU: 103010462(AICDA)
LVE: 103069988(AICDA)
OOR: 101285289(AICDA)
ECB: 100061137(AICDA)
EPZ: 103556648(AICDA)
EAI: 106837434(AICDA)
MYB: 102246875(AICDA)
MYD: 102754251(AICDA)
HAI: 109372744(AICDA)
RSS: 109435534(AICDA)
PALE: 102880164(AICDA)
LAV: 100656685(AICDA)
TMU: 101348216
MDO: 100013907(AICDA)
SHR: 100931157(AICDA)
OAA: 100085951(AICDA)
GGA: 418257(AICDA)
MGP: 100542460(AICDA)
CJO: 107318165(AICDA)
APLA: 101792498(AICDA)
ACYG: 106048067(AICDA)
TGU: 105758674(AICDA)
GFR: 102039832(AICDA)
FAB: 101816423(AICDA)
PHI: 102100565(AICDA)
PMAJ: 107212474(AICDA)
CCAE: 111925850(AICDA)
CCW: 104690263(AICDA)
FPG: 101914801(AICDA)
FCH: 102056463(AICDA)
CLV: 102087778(AICDA)
EGZ: 104122769(AICDA)
AAM: 106495707(AICDA)
ASN: 102376898(AICDA)
AMJ: 102558786(AICDA)
PSS: 102452729(AICDA)
CMY: 102933542(AICDA)
CPIC: 101942640(AICDA)
ACS: 100558459(aicda)
PVT: 110090848(AICDA)
PBI: 103050866(AICDA)
GJA: 107116093(AICDA)
XLA: 108697151(aicda.S) 734224(aicda.L)
XTR: 100497606(aicda)
NPR: 108799486(AICDA)
DRE: 493784(aicda)
CCAR: 109105833 109113171(aicda)
IPU: 100304619(aicda)
AMEX: 103042217(aicda)
TRU: 777999(aicda)
LCO: 104934638(aicda)
NCC: 104960416(aicda)
MZE: 101463826(aicda)
OLA: 101168236(aicda)
XMA: 102220777(aicda)
PRET: 103478041(aicda)
NFU: 107379531
KMR: 108235484(aicda)
CSEM: 103387859(aicda)
LCF: 108887318(aicda)
SDU: 111230178(aicda)
HCQ: 109515270(aicda)
BPEC: 110163179(aicda)
MALB: 109970232(aicda)
OTW: 112237113
ELS: 105019036
SFM: 108924694
LCM: 102350911(AICDA)
 » show all
Taxonomy
Reference
1  [PMID:12799424]
  Authors
Sohail A, Klapacz J, Samaranayake M, Ullah A, Bhagwat AS
  Title
Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations.
  Journal
Nucleic Acids Res 31:2990-4 (2003)
Reference
2  [PMID:17060445]
  Authors
Larijani M, Petrov AP, Kolenchenko O, Berru M, Krylov SN, Martin A
  Title
AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.
  Journal
Mol Cell Biol 27:20-30 (2007)
DOI:10.1128/MCB.00824-06
Reference
3  [PMID:17889624]
  Authors
Brar SS, Sacho EJ, Tessmer I, Croteau DL, Erie DA, Diaz M
  Title
Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.
  Journal
DNA Repair (Amst) 7:77-87 (2008)
DOI:10.1016/j.dnarep.2007.08.002
Reference
4  [PMID:17893327]
  Authors
Larijani M, Martin A
  Title
Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID.
  Journal
Mol Cell Biol 27:8038-48 (2007)
DOI:10.1128/MCB.01046-07
Reference
5  [PMID:19766322]
  Authors
Verma S, Goldammer T, Aitken R
  Title
Cloning and expression of activation induced cytidine deaminase from Bos taurus.
  Journal
Vet Immunol Immunopathol 134:151-9 (2010)
DOI:10.1016/j.vetimm.2009.08.016
  Sequence
[bta:539888]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.38
IUBMB Enzyme Nomenclature: 3.5.4.38
ExPASy - ENZYME nomenclature database: 3.5.4.38
BRENDA, the Enzyme Database: 3.5.4.38

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