KEGG   ENZYME: 3.5.4.6Help
Entry
EC 3.5.4.6                  Enzyme                                 

Name
AMP deaminase;
adenylic acid deaminase;
AMP aminase;
adenylic deaminase;
adenylate deaminase;
5-AMP deaminase;
adenosine 5-monophosphate deaminase;
5-adenylate deaminase;
adenyl deaminase;
5-adenylic acid deaminase;
adenosine monophosphate deaminase;
adenylate aminohydrolase;
adenylate desaminase;
adenosine 5-phosphate aminohydrolase;
5-adenylate deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
AMP aminohydrolase
Reaction(IUBMB)
AMP + H2O = IMP + NH3 [RN:R00181]
Reaction(KEGG)
Substrate
AMP [CPD:C00020];
H2O [CPD:C00001]
Product
IMP [CPD:C00130];
NH3 [CPD:C00014]
Comment
cf. EC 3.5.4.17 adenosine-phosphate deaminase.
History
EC 3.5.4.6 created 1961
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K01490  AMP deaminase
Genes
HSA: 270(AMPD1) 271(AMPD2) 272(AMPD3)
PTR: 451685(AMPD3) 457144(AMPD1) 469403(AMPD2)
PPS: 100967803(AMPD2) 100970920(AMPD1) 100985784(AMPD3)
GGO: 101125985(AMPD2) 101126353(AMPD3) 101144884(AMPD1)
PON: 100172675(AMPD2) 100445019(AMPD1) 100449661(AMPD3)
NLE: 100584841(AMPD2) 100590300(AMPD1) 100593142(AMPD3)
MCC: 699561(AMPD2) 703186(AMPD3) 708801(AMPD1)
MCF: 101866457(AMPD2) 102137521(AMPD3) 102140422(AMPD1)
CSAB: 103224170(AMPD1) 103224281(AMPD2) 103240330(AMPD3)
RRO: 104656009(AMPD2) 104669079(AMPD1) 104679293(AMPD3)
RBB: 108512622(AMPD3) 108519639(AMPD2) 108528120(AMPD1)
CJC: 100388245(AMPD3) 100414418(AMPD1) 100415495(AMPD2)
SBQ: 101032427(AMPD2) 101036228(AMPD1) 101050036(AMPD3)
MMU: 109674(Ampd2) 11717(Ampd3) 229665(Ampd1)
RNO: 25028(Ampd1) 25095(Ampd3) 362015(Ampd2)
CGE: 100757901(Ampd1) 100758386(Ampd3) 100774910(Ampd2)
NGI: 103728618 103734937(Ampd1) 103747833(Ampd2) 103750401(Ampd3)
HGL: 101704709(Ampd2) 101706263(Ampd3) 101718930(Ampd1)
CCAN: 109688835(Ampd2) 109690128(Ampd3) 109696059(Ampd1)
OCU: 100340249(AMPD2) 100344490(AMPD1) 100351884(AMPD3)
TUP: 102468470(AMPD3) 102477554(AMPD2) 102496095(AMPD1)
CFA: 479913(AMPD2) 606901(AMPD1)
AML: 100464697(AMPD1) 100466659(AMPD2) 100477550(AMPD3)
UMR: 103656395(AMPD3) 103669423(AMPD1) 103675203(AMPD2)
ORO: 101362692(AMPD3) 101363811(AMPD1) 101366223(AMPD2)
FCA: 101087346(AMPD3) 101090958(AMPD2) 101096963(AMPD1)
PTG: 102949961(AMPD2) 102953479(AMPD1) 102957680(AMPD3)
AJU: 106969597(AMPD1) 106971829(AMPD3) 106977836(AMPD2)
BTA: 512748(AMPD1) 514185(AMPD2) 519803(AMPD3)
BOM: 102268750(AMPD1) 102277495(AMPD3) 102284116(AMPD2)
BIU: 109555891(AMPD1) 109555969(AMPD2) 109568823(AMPD3)
PHD: 102317519(AMPD1) 102325504(AMPD2) 102344797(AMPD3)
CHX: 102176807(AMPD3) 102188819(AMPD1) 102190922(AMPD2)
OAS: 101102023(AMPD1) 101103503(AMPD3) 101107149(AMPD2)
SSC: 100101472(AMPD1) 100620914(AMPD3) 110260356(AMPD2)
CFR: 102504557(AMPD3) 102505000(AMPD2) 102508979(AMPD1)
CDK: 105085649(AMPD2) 105086614(AMPD3) 105089631(AMPD1)
BACU: 103004634(AMPD1) 103005329(AMPD3) 103007609(AMPD2)
LVE: 103078898(AMPD2) 103088000(AMPD3) 103090507(AMPD1)
OOR: 101274633(AMPD1) 101277956(AMPD2) 101279744(AMPD3)
ECB: 100055812(AMPD3) 100061723(AMPD2) 100065374(AMPD1)
EPZ: 103552676(AMPD1) 103557540 103559918(AMPD3)
EAI: 106827361(AMPD2) 106833101(AMPD3) 106835677(AMPD1)
MYB: 102244687(AMPD2) 102244745(AMPD3) 102247897(AMPD1)
MYD: 102760540(AMPD1) 102761028(AMPD2) 102773528(AMPD3)
HAI: 109375286(AMPD2) 109377009(AMPD1) 109390139(AMPD3)
RSS: 109440108 109446013(AMPD3) 109446694(AMPD1) 109446756(AMPD2)
PALE: 102885114(AMPD1) 102886544(AMPD3) 102893444(AMPD2)
LAV: 100665403(AMPD3) 100666070(AMPD2) 100677067(AMPD1)
MDO: 100009726(AMPD1) 100029814(AMPD3) 100033068(AMPD2)
SHR: 100917973(AMPD3) 100926149(AMPD1) 100928069 100929243(AMPD2)
OAA: 100074630(AMPD1) 100078866(AMPD3)
GGA: 112530327(AMPD2) 423041(AMPD3) 772125(AMPD1)
MGP: 100540618(AMPD1) 100543671(AMPD3) 100546778(AMPD2)
CJO: 107314602(AMPD3) 107324753(AMPD2) 107324813(AMPD1)
APLA: 101794720(AMPD1) 101803104(AMPD3) 101804503(AMPD2)
ACYG: 106040890(AMPD3) 106041321(AMPD1) 106049764(AMPD2)
TGU: 100226906(AMPD1) 100230537(AMPD3)
GFR: 102038635(AMPD2) 102039789(AMPD1) 102045151(AMPD3)
FAB: 101813859(AMPD1) 101814909(AMPD2) 101820483(AMPD3)
PHI: 102099965(AMPD2) 102110098(AMPD1) 102114251(AMPD3)
PMAJ: 107205644(AMPD3) 107214901(AMPD2) 107214946(AMPD1)
CCW: 104684653(AMPD3) 104692409(AMPD1) 104692564(AMPD2)
FPG: 101918699(AMPD2) 101919011(AMPD3) 101921823(AMPD1)
FCH: 102046952(AMPD3) 102054655(AMPD1) 102056466(AMPD2)
CLV: 102083441(AMPD1) 102085131(AMPD3) 102096385(AMPD2)
EGZ: 104123179(AMPD3) 104126806(AMPD1) 104127760(AMPD2)
AAM: 106485265(AMPD1) 106496940(AMPD2) 106497119(AMPD3)
ASN: 102375428(AMPD3) 102376899(AMPD2)
AMJ: 102569764(AMPD1) 102569951(AMPD2) 106736885(AMPD3)
PSS: 102447743(AMPD1) 102449256(AMPD3) 102455827(AMPD2)
CMY: 102931557(AMPD2) 102938472(AMPD1) 102942590(AMPD3)
CPIC: 101941907(AMPD2) 101943007(AMPD3) 101949142(AMPD1)
ACS: 100552392(ampd1) 100559571(ampd3) 100563338(ampd2)
PVT: 110072323(AMPD1) 110077153(AMPD3) 110085274(AMPD2)
PBI: 103054576(AMPD3) 103066047(AMPD1) 103067156(AMPD2)
GJA: 107106774(AMPD3) 107109031 107120787(AMPD2) 107125830(AMPD1)
XLA: 108708064(ampd1.L) 108709397(ampd1.S) 108709466(ampd2.S) 108713730(ampd3.L) 108715290(ampd3.S)
XTR: 100488507(ampd1) 100490248(ampd2) 595079(ampd3)
NPR: 108786202(AMPD3) 108795707(AMPD2) 108799546(AMPD1)
DRE: 100330772(ampd2a) 333997(ampd3b) 393867(ampd1) 556578(ampd3a) 571355(ampd2b)
IPU: 108264598 108265707(ampd1) 108265746(ampd2) 108270886(ampd3) 108281078(Ampd2)
SDU: 111218984(ampd2) 111222066 111229881 111230682(ampd1) 111236556(ampd3)
SFM: 108923248 108928241(ampd1) 108933798(ampd2) 108934688(ampd3) 108942444
LCM: 102345187(AMPD3) 102360788(AMPD1) 102363257(AMPD2)
CMK: 103182462(ampd2) 103189077(ampd3) 103189725(ampd1)
CIN: 100181582(ampd2)
SPU: 587814
SKO: 100366917(AMPD2)
DME: Dmel_CG32626(AMPdeam)
DSI: Dsimw501_GD26780(Dsim_GD26780)
MDE: 101900828
AAG: 5579456
AME: 409444
BIM: 100743683
BTER: 100644108
SOC: 105198658
AEC: 105150484
ACEP: 105627354
PBAR: 105427011
HST: 105180682
DQU: 106743701
CFO: 105255354
LHU: 105677384
PGC: 109854843
PCF: 106791338
NVI: 100123558
MDL: 103572417
TCA: 662645
DPA: 109536405
NVL: 108569514
API: 100167425
DNX: 107161774
ZNE: 110841387
FCD: 110844665
TUT: 107362843
CEL: CELE_C34F11.3(ampd-1)
CBR: CBG02349
BMY: Bm1_54650
MYI: 110456274
LAK: 106181987
EGL: EGR_08262
EPA: 110242796
AQU: 100635902
ATH: AT2G38280(FAC1)
CRB: 17889564
EGR: 104421999
LJA: Lj0g3v0128179.1(Lj0g3v0128179.1) Lj0g3v0277479.1(Lj0g3v0277479.1)
ZJU: 107430886
CSV: 101212419
CMO: 103502142
MCHA: 111019491
DOSA: Os05t0349200-01(Os05g0349200) Os07t0693500-01(Os07g0693500)
ATS: 109734900(LOC109734900) 109753999(LOC109753999)
PDA: 103697974
DCT: 110112272
PEQ: 110023708
APRO: F751_4597
SCE: YML035C(AMD1)
ERC: Ecym_4113
KMX: KLMA_70014(AMD1)
NCS: NCAS_0H02850(NCAS0H02850)
NDI: NDAI_0B04910(NDAI0B04910) NDAI_0C00780(NDAI0C00780)
TPF: TPHA_0K00260(TPHA0K00260)
TBL: TBLA_0C01920(TBLA0C01920) TBLA_0E02840(TBLA0E02840)
TDL: TDEL_0A04430(TDEL0A04430)
KAF: KAFR_0C05670(KAFR0C05670)
PIC: PICST_40926(AMD1)
CAL: CAALFM_C203360WA(CaO19.891)
CAUR: QG37_04682
SLB: AWJ20_2298(AMD1)
NCR: NCU02979
NTE: NEUTE1DRAFT150719(NEUTE1DRAFT_150719)
MGR: MGG_05630
SSCK: SPSK_01416
MAW: MAC_09074
MAJ: MAA_00253
CMT: CCM_09680
BFU: BCIN_15g02510(Bcamd1)
MBE: MBM_04346
ANI: AN8872.2
ANG: ANI_1_900034(An03g06970)
ABE: ARB_06421
TVE: TRV_01132
PNO: SNOG_16537(SNOG_16536)
PTE: PTT_06992
SPO: SPBC106.04(ada1)
CNE: CNC03570
CNB: CNBC3640
ABP: AGABI1DRAFT117790(AGABI1DRAFT_117790) AGABI1DRAFT120906(AGABI1DRAFT_120906)
ABV: AGABI2DRAFT186679(AGABI2DRAFT_186679) AGABI2DRAFT60662(AGABI2DRAFT_60662)
MGL: MGL_4178
DDI: DDB_G0292266(amdA)
DFA: DFA_01328(amdA)
EHI: EHI_029100(110.t00025)
PYO: PY17X_1349200(PY01044)
PCB: PCHAS_134900(PC000203.02.0)
CPV: cgd4_1890
SMIN: v1.2.006175.t1(symbB.v1.2.006175.t1)
PTI: PHATR_800
SPAR: SPRG_02987
 » show all
Taxonomy
Reference
1  [PMID:20285041]
  Authors
KALCKAR HM
  Title
Differential spectrophotometry of purine compounds by means of specific enzymes;  studies of the enzymes of purine metabolism.
  Journal
J Biol Chem 167:461-75 (1947)
Reference
2  [PMID:13463019]
  Authors
LEE YP.
  Title
5'-Adenylic acid deaminase. I. Isolation of the crystalline enzyme from rabbit skeletal muscle.
  Journal
J Biol Chem 227:987-92 (1957)
Reference
3  [PMID:13463020]
  Authors
LEE YP.
  Title
5'-Adenylic acid deaminase. II. Homogeneity and physicochemical properties.
  Journal
J Biol Chem 227:993-8 (1957)
Reference
4  [PMID:13463021]
  Authors
LEE YP.
  Title
5'-Adenylic acid deaminase. III. Properties and kinetic studies.
  Journal
J Biol Chem 227:999-1007 (1957)
Reference
5  [PMID:13563464]
  Authors
MENDICINO J, MUNTZ JA.
  Title
The activating effect of adenosine triphosphate on brain adenylic deaminase.
  Journal
J Biol Chem 233:178-83 (1958)
Reference
6  [PMID:13778717]
  Authors
TURNER DH, TURNER JF.
  Title
Adenylic deaminase of pea seeds.
  Journal
Biochem J 79:143-7 (1961)
Reference
7  [PMID:13260201]
  Authors
WEIL-MALHERBE H, GREEN RH.
  Title
Ammonia formation in brain.  II.  Brain adenylic deaminase.
  Journal
Biochem J 61:218-24 (1955)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.6
IUBMB Enzyme Nomenclature: 3.5.4.6
ExPASy - ENZYME nomenclature database: 3.5.4.6
BRENDA, the Enzyme Database: 3.5.4.6
CAS: 9025-10-9

DBGET integrated database retrieval system