KEGG   ENZYME: 3.5.5.1Help
Entry
EC 3.5.5.1                  Enzyme                                 

Name
nitrilase;
acetonitrilase;
benzonitrilase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In nitriles
BRITE hierarchy
Sysname
nitrile aminohydrolase
Reaction(IUBMB)
a nitrile + 2 H2O = a carboxylate + NH3 [RN:R00540]
Reaction(KEGG)
Substrate
nitrile [CPD:C00726];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
NH3 [CPD:C00014]
Comment
Acts on a wide range of aromatic nitriles including (indol-3-yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides. cf. EC 4.2.1.84 nitrile hydratase.
History
EC 3.5.5.1 created 1965, modified 1989
Pathway
ec00380  Tryptophan metabolism
ec00460  Cyanoamino acid metabolism
ec00627  Aminobenzoate degradation
ec00643  Styrene degradation
ec00910  Nitrogen metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K01501  nitrilase
Genes
CEL: CELE_ZK1058.6(nit-1)
CBR: CBG03597(Cbr-nit-1)
ATH: AT3G44300(NIT2) AT3G44310(NIT1) AT3G44320(NIT3)
ALY: ARALYDRAFT_323132 ARALYDRAFT_484849
CRB: 17877697 17886221
CSAT: 104710891 104773049 104780280 104790687 104790689
EUS: EUTSA_v10010499mg EUTSA_v10010504mg EUTSA_v10023557mg
BRP: 103848073 103851084(NIT-T1) 103856931(BrNIT3) 103865089(BrNIT1)
BNA: 106348366 106354428 106402388 106403172 106425068 106437374
BOE: 106320293 106327314 106333257 106339483
RCU: 8268610
OSA: 4330076
DOSA: Os02t0635000-01(Os02g0635000)
BDI: 100822233
SBI: 8074792
ZMA: 542573(NIT1)
SITA: 101766965
PIC: PICST_36697(NIT1)
NCR: NCU05387
MGR: MGG_03280
MAW: MAC_09596
MAJ: MAA_08327
ANI: AN7367.2
ANG: ANI_1_1394104(An12g01260) ANI_1_254054(An06g01960)
TCR: 510039.40
PPUH: B479_13035
PFL: PFL_2909
PPRC: PFLCHA0_c29550(nitA)
PFS: PFLU_2708
PEN: PSEEN3513
PAR: Psyc_0202
SSE: Ssed_0525
SPL: Spea_2863
SHL: Shal_2959
SVO: SVI_3911
PHA: PSHAa2676
KKO: Kkor_0639
ASA: ASA_2402
PSE: NH8B_1273
RSL: RPSI07_mp0987(nit)
BVE: AK36_140
BCN: Bcen_0220
BCJ: BCAL3323
BCEN: DM39_513(nit2)
BCEW: DM40_1397(nit4)
BCEO: I35_0552
BAM: Bamb_0595
BMU: Bmul_2680
BMK: DM80_966(nit2)
BCT: GEM_2822
BCED: DM42_1138(nit2)
BCON: NL30_20595
BUB: BW23_1032
BUK: MYA_0610
PNU: Pnuc_1777
BBR: BB1116
AXY: AXYL_01231(nit1) AXYL_01249(nit2)
POL: Bpro_3376
PNA: Pnap_4743
AAA: Acav_4464
MMS: mma_2480
DAR: Daro_3329
CJE: Cj1056c
CJR: CJE1199
SFU: Sfum_2312
MES: Meso_0079
SFH: SFHH103_06513(nit)
BJA: blr3397(nit)
RPA: RPA4166
RPT: Rpal_4645
XAU: Xaut_1567
MDI: METDI2664
CAK: Caul_5248
ZMO: ZMO1207
ZMN: Za10_0124
SWI: Swit_2469
ABS: AZOBR_p350044(nitA)
BSE: Bsel_2856
CKL: CKL_2025
CKR: CKR_1770
PDC: CDIF630_03109(nit)
MED: MELS_1676
AAU: AAur_0337
PDX: Psed_2545
RXY: Rxyl_0235
PSL: Psta_3064
SUS: Acid_5967
SLI: Slin_1649
HMA: pNG7354(nitB)
 » show all
Taxonomy
Reference
1  [PMID:21655]
  Authors
Harper DB.
  Title
Microbial metabolism of aromatic nitriles. Enzymology of C-N cleavage by Nocardia sp. (Rhodochrous group) N.C.I.B. 11216.
  Journal
Biochem J 165:309-19 (1977)
Reference
2  [PMID:14165487]
  Authors
THIMANN KV, MAHADEVAN S.
  Title
NITRILASE. I. OCCURRENCE, PREPARATION, AND GENERAL PROPERTIES OF THE ENZYME.
  Journal
Arch Biochem Biophys 105:133-41 (1964)
DOI:10.1016/0003-9861(64)90244-9
Reference
3  [PMID:11380987]
  Authors
Pace HC, Brenner C.
  Title
The nitrilase superfamily: classification, structure and function.
  Journal
Genome Biol 2:REVIEWS0001 (2001)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.5.1
IUBMB Enzyme Nomenclature: 3.5.5.1
ExPASy - ENZYME nomenclature database: 3.5.5.1
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.5.1
BRENDA, the Enzyme Database: 3.5.5.1
CAS: 9024-90-2

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