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Entry
EC 3.5.5.8                  Enzyme                                 

Name
thiocyanate hydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In nitriles
BRITE hierarchy
Sysname
thiocyanate aminohydrolase
Reaction(IUBMB)
thiocyanate + 2 H2O = carbonyl sulfide + NH3 + HO- [RN:R05780]
Reaction(KEGG)
Substrate
thiocyanate [CPD:C01755];
H2O [CPD:C00001]
Product
carbonyl sulfide [CPD:C07331];
NH3 [CPD:C00014];
HO- [CPD:C01328]
Comment
The enzyme from Thiobacillus thioparus catalyses the first step in the degradation of thiocyanate.
History
EC 3.5.5.8 created 2000
Orthology
K20760  thiocyanate hydrolase subunit alpha
K20761  thiocyanate hydrolase subunit beta
K20762  thiocyanate hydrolase subunit gamma
Genes
LPO: LPO_1236(scnC) LPO_1237 LPO_1238
LPP: lpp1219 lpp1220 lpp1221
LLO: LLO_1905
LSH: CAB17_12325(scnC)
SVA: SVA_2685 SVA_2686 SVA_2687 SVA_2692
MPO: Mpop_4230 Mpop_4231
RHZ: RHPLAN_42300
AZM: DM194_21620(scnC) DM194_21625
MIT: OCO_27870 OCO_27880
MIA: OCU_27740 OCU_27750
MPHL: MPHLCCUG_02409(scnB) MPHLCCUG_02410(scnC)
ROP: ROP_43440(scnC) ROP_43450(scnA) ROP_43460(scnB)
GRU: GCWB2_23795(scnB) GCWB2_23800(scnC)
KAL: KALB_3445
 » show all
Taxonomy
Reference
1  [PMID:9573140]
  Authors
Katayama Y, Matsushita Y, Kaneko M, Kondo M, Mizuno T, Nyunoya H.
  Title
Cloning of genes coding for the three subunits of thiocyanate hydrolase of Thiobacillus thioparus THI 115 and their evolutionary relationships to nitrile hydratase.
  Journal
J Bacteriol 180:2583-9 (1998)
  Sequence
Reference
2  [PMID:1577754]
  Authors
Katayama Y, Narahara Y, Inoue Y, Amano F, Kanagawa T, Kuraishi H.
  Title
A thiocyanate hydrolase of Thiobacillus thioparus. A novel enzyme catalyzing the formation of carbonyl sulfide from thiocyanate.
  Journal
J Biol Chem 267:9170-5 (1992)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.5.8
IUBMB Enzyme Nomenclature: 3.5.5.8
ExPASy - ENZYME nomenclature database: 3.5.5.8
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.5.8
BRENDA, the Enzyme Database: 3.5.5.8
CAS: 142539-65-9

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