KEGG   ENZYME: 3.5.99.5Help
Entry
EC 3.5.99.5                 Enzyme                                 

Name
2-aminomuconate deaminase;
amnD (gene name);
nbaF (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
BRITE hierarchy
Sysname
2-aminomuconate aminohydrolase
Reaction(IUBMB)
2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH3 [RN:R03887]
Reaction(KEGG)
Substrate
2-aminomuconate [CPD:C02220];
H2O [CPD:C00001]
Product
(3E)-2-oxohex-3-enedioate;
NH3 [CPD:C00014]
Comment
2-Aminomuconate is an intermediate in the bacterial biodegradation of nitrobenzene. The enzyme has been isolated from several species, including Pseudomonas pseudocaligenes JS45, Pseudomonas fluorescens KU-7, Pseudomonas sp. AP3 and Burkholderia cenocepacia J2315. The reaction is spontaneous in acid conditions.
History
EC 3.5.99.5 created 2000, modified 2012
Pathway
ec00380  Tryptophan metabolism
Orthology
K15067  2-aminomuconate deaminase
Genes
TMN: UCRPA7_5979
NHE: NECHADRAFT_19718 NECHADRAFT_51933
ELA: UCREL1_9179
PFY: PFICI_02122
AFV: AFLA_042520
BOR: COCMIDRAFT_4779
DDI: DDB_G0275081
DPP: DICPUDRAFT_29711
SLQ: M495_05195
LAB: LA76x_2546(amnD)
LAQ: GLA29479_1095(amnD)
LCP: LC55x_2796(amnD)
LGU: LG3211_2668(amnD)
LEZ: GLE_2674
LEM: LEN_2361
DKO: I596_660
PCQ: PcP3B5_23520(amnD)
PKC: PKB_3260(amnd1) PKB_3608(amnd3)
PSOS: POS17_2259
PSET: THL1_488
SWD: Swoo_1409
SALH: HMF8227_02736(amnD)
KKO: Kkor_0381
KGE: TQ33_1985
RIN: ACS15_4681(amnD)
RME: Rmet_5211(amnD)
BCJ: BCAM2131(nbaF)
BCEO: I35_6013(nbaF)
BMUL: NP80_3863(amnD)
BXE: Bxe_A1148(amnD) Bxe_A1831
BXB: DR64_3307(amnD) DR64_3993(amnD)
BFN: OI25_253
PPNO: DA70_24005
PPNM: LV28_06700
PPUL: RO07_00740
PSPU: NA29_10885
PAPI: SG18_00955
BAV: BAV0553(amnE)
BHZ: ACR54_00825(amnD_1)
AXX: ERS451415_05309(amnD)
PUT: PT7_3612
POL: Bpro_5138
MXA: MXAN_0920
CCX: COCOR_00870(tdcF)
SMAZ: LH19_00755
SGI: SGRAN_3550(amnD)
SWI: Swit_3522
SPHD: HY78_06670
SPKC: KC8_11580
REY: O5Y_02270
REQ: REQ_05060
RRT: 4535765_01256(amnD)
SCB: SCAB_15171(amnE)
KFL: Kfla_5492
SRO: Sros_9111
SAQ: Sare_3898
MIL: ML5_3359
GES: VT84_05910(amnD)
HSW: Hsw_3527
DDO: I597_1378(amnD)
NDO: DDD_1880
WIN: WPG_2049
TJE: TJEJU_1408(amnD)
TMAR: MARIT_1043(amnD)
KOS: KORDIASMS9_02220(amnD)
MARF: CJ739_784
 » show all
Taxonomy
Reference
1  [PMID:9471964]
  Authors
He Z, Spain JC.
  Title
Studies of the catabolic pathway of degradation of nitrobenzene by Pseudomonas pseudoalcaligenes JS45: removal of the amino group from 2-aminomuconic semialdehyde.
  Journal
Appl Environ Microbiol 63:4839-43 (1997)
Reference
2  [PMID:9573204]
  Authors
He Z, Spain JC.
  Title
A novel 2-aminomuconate deaminase in the nitrobenzene degradation pathway of Pseudomonas pseudoalcaligenes JS45.
  Journal
J Bacteriol 180:2502-6 (1998)
Reference
3  [PMID:11081795]
  Authors
Takenaka S, Murakami S, Kim YJ, Aoki K
  Title
Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3.
  Journal
Arch Microbiol 174:265-72 (2000)
  Sequence
Reference
4  [PMID:12620844]
  Authors
Muraki T, Taki M, Hasegawa Y, Iwaki H, Lau PC.
  Title
Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7.
  Journal
Appl Environ Microbiol 69:1564-72 (2003)
DOI:10.1128/AEM.69.3.1564-1572.2003
Other DBs
ExplorEnz - The Enzyme Database: 3.5.99.5
IUBMB Enzyme Nomenclature: 3.5.99.5
ExPASy - ENZYME nomenclature database: 3.5.99.5
BRENDA, the Enzyme Database: 3.5.99.5
CAS: 201098-29-5

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