KEGG   ENZYME: 3.5.99.7Help
Entry
EC 3.5.99.7                 Enzyme                                 

Name
1-aminocyclopropane-1-carboxylate deaminase;
1-aminocyclopropane-1-carboxylate endolyase (deaminating);
ACC deaminase;
1-aminocyclopropane carboxylic acid deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
BRITE hierarchy
Sysname
1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)
Reaction(IUBMB)
1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3 (overall reaction) [RN:R00997];
(1a) 1-aminocyclopropane-1-carboxylate = 2-aminobut-2-enoate;
(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);
(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous)
Reaction(KEGG)
Substrate
1-aminocyclopropane-1-carboxylate [CPD:C01234];
H2O [CPD:C00001];
2-aminobut-2-enoate [CPD:C17234];
2-iminobutanoate [CPD:C20905]
Product
2-oxobutanoate [CPD:C00109];
NH3 [CPD:C00014];
2-aminobut-2-enoate [CPD:C17234];
2-iminobutanoate [CPD:C20905]
Comment
A pyridoxal 5'-phosphate enzyme. The enzyme, found in certain soil bacteria and fungi, catalyses the ring opening of 1-aminocyclopropane-1-carboxylate, the immediate precursor to ethylene, an important plant hormone that regulates fruit ripening and other processes. The enzyme releases an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme has been used to make fruit ripening dependent on externally added ethylene, as it removes the substrate for endogenous ethylene formation.
History
EC 3.5.99.7 created 1981 as EC 4.1.99.4, transferred 2002 to EC 3.5.99.7, modified 2014
Pathway
ec00270  Cysteine and methionine metabolism
Orthology
K01505  1-aminocyclopropane-1-carboxylate deaminase
Genes
CLU: CLUG_04006
CLUS: A9F13_01g01166
NCR: NCU04657
NTE: NEUTE1DRAFT77478(NEUTE1DRAFT_77478)
SMP: SMAC_08345
PAN: PODANSg8093
TTT: THITE_2106728
MTM: MYCTH_2300602
CTHR: CTHT_0053040
MGR: MGG_02812
CMT: CCM_05164
MBE: MBM_08531
ANI: AN8899.2
ANG: ANI_1_1508084(An09g05780)
ABE: ARB_06454
TVE: TRV_04175
CNE: CNB00190
CNB: CNBB5480
DDQ: DDI_0228
TPTY: NCTC11468_02224(acdS)
PAE: PA3089a
PAEV: N297_3196
PAEI: N296_3196
PAEP: PA1S_09930
PAEM: U769_09470
PAEL: T223_09950
PAEG: AI22_23930
PAEC: M802_3193
PAEO: M801_3061
PMY: Pmen_2947
PMK: MDS_3227
PPSE: BN5_2745(dcyD)
PCQ: PcP3B5_17960(acdS)
PPU: PP_2009
PPF: Pput_3733
PPT: PPS_1596
PPI: YSA_01765
PPX: T1E_1008
PPUH: B479_07720
PPUT: L483_07380
PPUN: PP4_38260
PPUD: DW66_1885
PMON: X969_06010
PMOT: X970_05985
PFL: PFL_3968
PPRO: PPC_4067
PFS: PFLU_3914
PFW: PF1751_v1c33520(acdS)
PFB: VO64_0992
PMAN: OU5_1267
PEN: PSEEN1704
PSA: PST_1815
PSTT: CH92_13290
PKC: PKB_3850
PSEM: TO66_20560
PSOS: POS17_4077
PANR: A7J50_3575
PSET: THL1_2047
PSIL: PMA3_08180
ABN: AB57_0823
ABX: ABK1_0770
ABH: M3Q_977
ABAD: ABD1_07270
ABAZ: P795_13830
ABAU: IX87_18185
ABAA: IX88_05855
ACC: BDGL_000040(dcyD)
SFR: Sfri_2321
SAZ: Sama_1576
CPS: CPS_4580
PHA: PSHAa2700(dcyD)
PAT: Patl_0753
PSM: PSM_A0328
PSEO: OM33_04675
PPHE: PP2015_222
PSPO: PSPO_a0330
PART: PARC_a0442
PSEN: PNC201_01685(dcyD)
AMAL: I607_14795
AMAE: I876_15095
AMAO: I634_15040
AMAD: I636_14895
AMAI: I635_15470
AMAG: I533_14615
AMAC: MASE_14645
AAUS: EP12_15395
ASP: AOR13_359
GNI: GNIT_2769
GPS: C427_0700
PIN: Ping_3031
CJA: CJA_2178
SDE: Sde_1730
SAGA: M5M_00930
MICC: AUP74_02359(dcyD)
LPN: lpg1367
LPH: LPV_1480
LPO: LPO_1356
LPM: LP6_1348
LPF: lpl1318
LPP: lpp1321
LPC: LPC_0783
LPA: lpa_02014(rimM)
LPE: lp12_1305
LFA: LFA_1291
FTH: FTH_0847
TEE: Tel_03215
HCH: HCH_04594
HAM: HALO0593
KGE: TQ33_0478
TOL: TOL_1133
AHA: AHA_0384
ASA: ASA_3948(acdS)
AVR: B565_3671
AMED: B224_6071
ACAV: VI35_19500
OCE: GU3_04080
RSO: RSp0646(acdS)
RSL: RPSI07_mp0523(acdS)
RSN: RSPO_m00987(acdS)
RSM: CMR15_mp10599(acdS)
RSE: F504_4579
RPI: Rpic_2004
REH: H16_B1365(acd)
BMA: BMAA0952
BMAL: DM55_4507
BMAE: DM78_3669
BMAQ: DM76_3457
BMAI: DM57_09060
BMAF: DM51_4637
BMAZ: BM44_4464
BMAB: BM45_3588
BPS: BPSS1324
BPSE: BDL_4624
BPSM: BBQ_4830
BPSU: BBN_4764
BPSD: BBX_3788
BPK: BBK_5773
BPSH: DR55_3956
BPSA: BBU_4722
BPSO: X996_4536
BUT: X994_5801
BTQ: BTQ_4390
BTJ: BTJ_5371
BTZ: BTL_3831
BTD: BTI_3827
BTV: BTHA_4046
BTHE: BTN_3827
BTHM: BTRA_4527
BTHA: DR62_3867
BTHL: BG87_3846
BOK: DM82_5508
BOC: BG90_5102
BVE: AK36_4782
BCN: Bcen_4794
BCJ: BCAM0385
BCEN: DM39_4760
BCEW: DM40_3548
BCEO: I35_4289
BAM: Bamb_5155
BMU: Bmul_5215
BMK: DM80_4428
BMUL: NP80_3522
BCT: GEM_5346
BCED: DM42_4767
BDL: AK34_4916
BCON: NL30_24070
BUB: BW23_4197
BLAT: WK25_20170
BTEI: WS51_00815
BPSL: WS57_11670
BMEC: WJ16_21005
BSTG: WT74_21385
BGU: KS03_4569
BGO: BM43_4957
BUK: MYA_3594
BUE: BRPE67_CCDS15320(acdS)
BUL: BW21_5820
BXE: Bxe_B1212
BXB: DR64_6528
BFN: OI25_6969
PLG: NCTC10937_01765(acdS)
AXX: ERS451415_01542(acdS_1)
ODI: ODI_R1068
POL: Bpro_3828
AJS: Ajs_3877
AAA: Acav_4387
ACRA: BSY15_995
VPD: VAPA_1c52900(acdS)
MPT: Mpe_A3598
HSE: Hsero_3193(acd)
HRB: Hrubri_3206(acd)
CFU: CFU_0114(acdS) CFU_2070
CJE: Cj0600
CJR: CJE0703
CCV: CCV52592_0110(acd)
MLO: mlr5932
SMX: SM11_pC0176(acdS)
SMD: Smed_6456
SAME: SAMCFNEI73_pB0147(acdS)
ARA: Arad_8832
AVI: Avi_5856
REL: REMIM1_PE00376(acdS)
REI: IE4771_PB00118(acdS)
RLE: pRL100087(acdS)
RTR: RTCIAT899_PB01615(acdS)
RGA: RGR602_PB00298(acdS)
SHZ: shn_25900
BJA: blr0241
BRA: BRADO3803
BBT: BBta_4127
BRS: S23_05660(acaS)
BRAD: BF49_0542
AZC: AZC_0267
SNO: Snov_0529
MET: M446_0271
MNO: Mnod_5479
MOR: MOC_1898
MAQU: Maq22A_c09240(acdS)
SPSE: SULPSESMR1_04053(acdS)
GOH: B932_0619
AMV: ACMV_24830(acdS)
GXY: GLX_00860
ALI: AZOLI_p20559(acdS)
TMO: TMO_c0455(acdS)
TXI: TH3_03390
MVQ: MYVA_5834
MAB: MAB_1704c
MABB: MASS_1797
MABO: NF82_08620
MCHE: BB28_09255
MSTE: MSTE_01704
RFA: A3L23_00969(acdS)
RHS: A3Q41_02383(acdS)
SCO: SCO5247(2SC7G11.09c)
SGB: WQO_24140
SCT: SCAT_4106
SFA: Sfla_2043
SBH: SBI_06362
SHY: SHJG_6359
SALS: SLNWT_2052
STRP: F750_4777
SFI: SFUL_5062
SALU: DC74_5399
SALL: SAZ_28605
STRE: GZL_03459
SLD: T261_2799
STRM: M444_23050
SPRI: SPRI_2629
SRW: TUE45_02395(acdS_1) TUE45_05762(acdS_2)
SLE: sle_24920(sle_24920)
SRN: A4G23_03861(dcyD)
SLAU: SLA_5082
SALJ: SMD11_2288
SLX: SLAV_13370(dcyD)
KSK: KSE_25040
SERJ: SGUI_0611
BLIN: BLSMQ_0090
MPH: MLP_08180
KFL: Kfla_2514
MGG: MPLG2_1921(acdS)
NDA: Ndas_5444
FAL: FRAAL4411
NML: Namu_2828
MMAR: MODMU_0104(acdS)
SEN: SACE_1968 SACE_2778(acd)
AMD: AMED_6059
AMN: RAM_31065
AMM: AMES_5974
AMZ: B737_5974
AOI: AORI_5074
AJA: AJAP_14120(acdS)
AMQ: AMETH_2787(acd)
PDX: Psed_1054
AMI: Amir_1412
SESP: BN6_16700(acdS)
ACTI: UA75_20950
ACAD: UA74_20445
AHG: AHOG_18300(acdS)
ACTN: L083_5619
AFS: AFR_06190
CAI: Caci_6027
SNA: Snas_1895
ANA: alr4447
AVA: Ava_1372
NAZ: Aazo_0431
NSP: BMF81_03051(cuyA)
MRB: Mrub_0941
LIL: LA_1889
LIE: LIF_A1518
LIC: LIC_12009
LIS: LIL_12128(acd)
LBJ: LBJ_1506
LBL: LBL_1730
LST: LSS_09953
CPI: Cpin_1914
FLN: FLA_4522
SMIZ: 4412673_02379(dcyD_2)
MUC: MuYL_1434
MGOT: MgSA37_01358(cuyA)
CHU: CHU_3479(yedO)
FAE: FAES_2595
HSW: Hsw_0321
FLM: MY04_3074
GFO: GFO_0238
GFL: GRFL_2026
FJO: Fjoh_1912
FJG: BB050_00693(acdS)
FPS: FP1206(acdS)
FBR: FBFL15_2371(acdS)
FIN: KQS_10945(acdS)
COC: Coch_1781
ZPR: ZPR_0795
RAI: RA0C_2012
RAR: RIA_0467
RAG: B739_0146
RAE: G148_1870
RAT: M949_0581
MARM: YQ22_04745
CBAL: M667_01870
CBAT: M666_01890
DDO: I597_1125(dcyD)
ZGA: ZOBELLIA_965(dcyD)
MLT: VC82_889
NDO: DDD_2211
EAO: BD94_0747
ELB: VO54_01929(acdS)
MPW: MPR_3250
CHZ: CHSO_3846(acdS)
CTAK: 4412677_01003(dcyD)
WIN: WPG_0665
TMAR: MARIT_0762
AALG: AREALGSMS7_00522(acdS)
KOS: KORDIASMS9_01984(dcyD)
MARF: CJ739_2245
FBA: FIC_02085
IAL: IALB_2756(dcyD)
PHO: PH0054(PH0054)
PAB: PAB2303
PFU: PF0010
PFI: PFC_08160
PYN: PNA2_0578
PYS: Py04_0127
THA: TAM4_1367
TNU: BD01_1551
TEU: TEU_04190
 » show all
Taxonomy
Reference
1
  Authors
Honma, M. and Shimomura, T.
  Title
Metabolism of 1-aminocyclopropane-1-carboxylic acid.
  Journal
Agric Biol Chem 42:1825-1831 (1978)
Reference
2  [PMID:10938279]
  Authors
Yao M, Ose T, Sugimoto H, Horiuchi A, Nakagawa A, Wakatsuki S, Yokoi D, Murakami T, Honma M, Tanaka I.
  Title
Crystal structure of 1-aminocyclopropane-1-carboxylate deaminase from Hansenula saturnus.
  Journal
J Biol Chem 275:34557-65 (2000)
DOI:10.1074/jbc.M004681200
Reference
3  [PMID:21244019]
  Authors
Thibodeaux CJ, Liu HW
  Title
Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction.
  Journal
Biochemistry 50:1950-62 (2011)
DOI:10.1021/bi101927s
Other DBs
ExplorEnz - The Enzyme Database: 3.5.99.7
IUBMB Enzyme Nomenclature: 3.5.99.7
ExPASy - ENZYME nomenclature database: 3.5.99.7
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.99.7
BRENDA, the Enzyme Database: 3.5.99.7
CAS: 69553-48-6

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