KEGG   ENZYME: 3.6.1.12Help
Entry
EC 3.6.1.12                 Enzyme                                 

Name
dCTP diphosphatase;
DCTPP1 (gene name);
deoxycytidine-triphosphatase;
dCTPase;
dCTP pyrophosphatase;
deoxycytidine triphosphatase;
deoxy-CTPase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
dCTP nucleotidohydrolase
Reaction(IUBMB)
dCTP + H2O = dCMP + diphosphate [RN:R01668]
Reaction(KEGG)
R01668;
(other) R01667
Show
Substrate
dCTP [CPD:C00458];
H2O [CPD:C00001]
Product
dCMP [CPD:C00239];
diphosphate [CPD:C00013]
Comment
The mammalian enzyme also displays weak activity against dTTP and dATP, but none against dGTP. Activity is highest with analogs including 5-iodo-dCTP and 5-methyl-dCTP.
History
EC 3.6.1.12 created 1965
Pathway
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K16904  dCTP diphosphatase
K21503  dCTP pyrophosphatase
Genes
HSA: 79077(DCTPP1)
PTR: 467948(DCTPP1)
PPS: 100980571(DCTPP1)
GGO: 101138322(DCTPP1)
PON: 112129388(DCTPP1)
NLE: 100584469(DCTPP1)
MCC: 710500(DCTPP1)
MCF: 102118443(DCTPP1)
CSAB: 103230924(DCTPP1)
RRO: 104681570(DCTPP1)
RBB: 108535403(DCTPP1)
CJC: 100408453(DCTPP1)
SBQ: 101051189(DCTPP1)
MMU: 66422(Dctpp1)
RNO: 192252(Dctpp1)
CGE: 100769832(Dctpp1)
NGI: 103726355(Dctpp1)
CCAN: 109682528(Dctpp1)
OCU: 100357182(DCTPP1)
TUP: 102469976(DCTPP1)
CFA: 489903(DCTPP1)
AML: 100479684(DCTPP1)
UMR: 103657859(DCTPP1)
ORO: 101370099(DCTPP1)
FCA: 101094313(DCTPP1)
PTG: 102950940(DCTPP1)
AJU: 106979130(DCTPP1)
BTA: 614103(DCTPP1)
BOM: 102282512(DCTPP1)
BIU: 109578812(DCTPP1)
PHD: 102342910(DCTPP1)
CHX: 102171294(DCTPP1)
OAS: 101121995(DCTPP1)
SSC: 100621901(DCTPP1)
CFR: 102520187(DCTPP1)
CDK: 105102738(DCTPP1)
BACU: 103015138(DCTPP1)
LVE: 103086998(DCTPP1)
OOR: 101278397(DCTPP1)
ECB: 100065556(DCTPP1)
EPZ: 103547216(DCTPP1)
EAI: 106831921(DCTPP1)
MYB: 102241958 102244697(DCTPP1)
MYD: 102753729(DCTPP1)
HAI: 109374219(DCTPP1)
RSS: 109437810(DCTPP1)
PALE: 102878907(DCTPP1)
LAV: 104846757(DCTPP1)
TMU: 101349736
MDO: 100017749(DCTPP1)
SHR: 100932588(DCTPP1)
OAA: 100093573(DCTPP1)
CPIC: 103306816(DCTPP1)
ACS: 100558769(dctpp1)
PVT: 110090066(DCTPP1)
PBI: 103056195(DCTPP1)
GJA: 107106259(DCTPP1)
XLA: 444233(dctpp1.L)
XTR: 493314(dctpp1)
NPR: 108803495(DCTPP1)
DRE: 393744(dctpp1)
SRX: 107745859(dctpp1)
SGH: 107600637(dctpp1)
IPU: 108260658(dctpp1)
AMEX: 103022470(dctpp1)
TRU: 101062264(dctpp1)
LCO: 104917965(dctpp1)
NCC: 104963069(dctpp1)
MZE: 101486589(dctpp1)
OLA: 101157671(dctpp1)
XMA: 102238234(dctpp1)
PRET: 103457678(dctpp1)
NFU: 107395640(dctpp1)
KMR: 108237872(dctpp1)
LCF: 108893079(dctpp1)
SDU: 111216683(dctpp1)
HCQ: 109511341(dctpp1)
BPEC: 110167623(dctpp1)
MALB: 109955505(dctpp1)
SASA: 100196870(xtp3a)
OTW: 112235798
ELS: 105020920(dctpp1)
SFM: 108924365(dctpp1)
LCM: 102360709(DCTPP1)
SPU: 574993
APLC: 110987035
SKO: 100372648
MYI: 110452454
OBI: 106878263
LAK: 106152627
EPA: 110250962
ADF: 107341540
HMG: 100201866
ATH: AT3G25400
CRB: 17893269
BRP: 103828559
BOE: 106306802
CPAP: 110821737
CAM: 101508420
LJA: Lj0g3v0107379.1(Lj0g3v0107379.1) Lj4g3v1683160.1(Lj4g3v1683160.1)
DOSA: Os02t0479300-01(Os02g0479300) Os04t0346800-01(Os04g0346800) Os04t0515400-00(Os04g0515400)
ATS: 109745662(LOC109745662) 109759876(LOC109759876)
MIS: MICPUN_113203(XTP3A)
SPAR: SPRG_03566
 » show all
Taxonomy
Reference
1  [PMID:13788541]
  Authors
ZIMMERMAN SB, KORNBERG A.
  Title
Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Eschrichia coli.
  Journal
J Biol Chem 236:1480-6 (1961)
Reference
2  [PMID:15740738]
  Authors
Moroz OV, Murzin AG, Makarova KS, Koonin EV, Wilson KS, Galperin MY
  Title
Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions.
  Journal
J Mol Biol 347:243-55 (2005)
DOI:10.1016/j.jmb.2005.01.030
Reference
3  [PMID:17320107]
  Authors
Wu B, Liu Y, Zhao Q, Liao S, Zhang J, Bartlam M, Chen W, Rao Z
  Title
Crystal structure of RS21-C6, involved in nucleoside triphosphate pyrophosphohydrolysis.
  Journal
J Mol Biol 367:1405-12 (2007)
DOI:10.1016/j.jmb.2007.01.057
  Sequence
[mmu:66422]
Reference
4  [PMID:19220460]
  Authors
Nonaka M, Tsuchimoto D, Sakumi K, Nakabeppu Y
  Title
Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine.
  Journal
FEBS J 276:1654-66 (2009)
DOI:10.1111/j.1742-4658.2009.06898.x
Reference
5  [PMID:24467396]
  Authors
Requena CE, Perez-Moreno G, Ruiz-Perez LM, Vidal AE, Gonzalez-Pacanowska D
  Title
The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells.
  Journal
Biochem J 459:171-80 (2014)
DOI:10.1042/BJ20130894
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.12
IUBMB Enzyme Nomenclature: 3.6.1.12
ExPASy - ENZYME nomenclature database: 3.6.1.12
BRENDA, the Enzyme Database: 3.6.1.12
CAS: 9024-87-7

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