KEGG   ENZYME: 3.6.1.17Help
Entry
EC 3.6.1.17                 Enzyme                                 

Name
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical);
bis(5'-guanosyl)-tetraphosphatase;
bis(5'-adenosyl)-tetraphosphatase;
diguanosinetetraphosphatase (asymmetrical);
dinucleosidetetraphosphatase (asymmetrical);
diadenosine P1,P4-tetraphosphatase;
dinucleoside tetraphosphatase;
1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Reaction(IUBMB)
P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP [RN:R01232]
Reaction(KEGG)
Substrate
P1,P4-bis(5'-guanosyl) tetraphosphate [CPD:C01261];
H2O [CPD:C00001]
Product
GTP [CPD:C00044];
GMP [CPD:C00144]
Comment
Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate [cf. EC 3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)]
History
EC 3.6.1.17 created 1972, modified 1976, modified 1986
Pathway
ec00230  Purine metabolism
ec00240  Pyrimidine metabolism
Orthology
K01518  bis(5'-nucleosidyl)-tetraphosphatase
Genes
HSA: 318(NUDT2)
PTR: 465056(NUDT2)
PPS: 100971204(NUDT2)
GGO: 101152305(NUDT2)
PON: 100457720(NUDT2)
NLE: 100585591(NUDT2)
MCC: 701795(NUDT2)
MCF: 102144582(NUDT2)
CSAB: 103219273(NUDT2)
RRO: 104680000(NUDT2)
RBB: 108542177(NUDT2)
CJC: 100391999(NUDT2)
SBQ: 101041101(NUDT2)
MMU: 66401(Nudt2)
RNO: 100910067 297998(Nudt2)
CGE: 100769146(Nudt2)
NGI: 103741578(Nudt2)
HGL: 101699878(Nudt2)
CCAN: 109686494(Nudt2)
OCU: 100343183(NUDT2)
TUP: 102486667(NUDT2)
CFA: 474746(NUDT2)
AML: 100480031(NUDT2)
UMR: 103667047(NUDT2)
ORO: 101367590(NUDT2)
FCA: 101082099(NUDT2)
PTG: 102968333(NUDT2)
AJU: 106975853(NUDT2)
BTA: 768044(NUDT2)
BOM: 102273937(NUDT2)
BIU: 109563186(NUDT2)
PHD: 102336471(NUDT2)
CHX: 102169758(NUDT2)
OAS: 101123091(NUDT2)
SSC: 397577(NUDT2)
CFR: 102521003(NUDT2)
CDK: 105085587(NUDT2)
BACU: 103006665(NUDT2)
LVE: 103079666(NUDT2)
OOR: 101278417(NUDT2)
ECB: 100054044(NUDT2)
EPZ: 103564364(NUDT2)
EAI: 106841396(NUDT2)
MYB: 102259354(NUDT2)
MYD: 102754972(NUDT2)
HAI: 109371792(NUDT2)
RSS: 109448770(NUDT2)
PALE: 102896710(NUDT2)
LAV: 100657619(NUDT2)
TMU: 101361419
MDO: 100021241(NUDT2)
SHR: 100923669(NUDT2)
OAA: 100088234(NUDT2)
GGA: 427399(NUDT2)
MGP: 100549295(NUDT2)
CJO: 107305739(NUDT2)
APLA: 101790344(NUDT2)
ACYG: 106045165(NUDT2)
TGU: 100225183(NUDT2)
GFR: 102037058(NUDT2)
FAB: 101813659(NUDT2)
PHI: 102108717(NUDT2)
PMAJ: 107216319(NUDT2)
CCW: 104686550(NUDT2)
FPG: 101924519(NUDT2)
FCH: 102057462(NUDT2)
CLV: 102090406(NUDT2)
EGZ: 104133822(NUDT2)
AAM: 106493695(NUDT2)
ASN: 102378006(NUDT2)
AMJ: 102575786(NUDT2)
PSS: 102448176(NUDT2)
CMY: 102936506(NUDT2)
CPIC: 101952762(NUDT2)
ACS: 100565132(nudt2)
PVT: 110080485(NUDT2)
PBI: 103055787(NUDT2)
GJA: 107122912(NUDT2)
XLA: 100049779(nudt2.S)
XTR: 448765(nudt2)
NPR: 108797456(NUDT2)
DRE: 436595(nudt2)
SRX: 107739745
SANH: 107661859
SGH: 107579639
CCAR: 109054174
IPU: 108278969(nudt2)
AMEX: 103027026(nudt2)
TRU: 101079847(nudt2)
LCO: 104928938(nudt2)
NCC: 104941147(nudt2)
MZE: 101464848(nudt2)
OLA: 101167782(nudt2)
XMA: 102237226(nudt2)
PRET: 103464996(nudt2)
NFU: 107385477(nudt2)
CSEM: 103386417(nudt2)
LCF: 108899692(nudt2)
HCQ: 109522578(nudt2)
BPEC: 110166722(nudt2)
SASA: 106583421(nudt2)
ELS: 105016785(nudt2)
SFM: 108931196(nudt2)
CMK: 103180986(nudt2)
SPU: 756973
APLC: 110987942
SKO: 100371369
DME: Dmel_CG31713(Apf)
DER: 6541522
DSI: Dsimw501_GD11976(Dsim_GD11976)
DWI: 6642607
MDE: 101901313
AAG: 5573956
AME: 724681
BIM: 100743272
BTER: 100645111
SOC: 105203166
AEC: 105154300
ACEP: 105618775
HST: 105183962
CFO: 105256553
LHU: 105675125
PGC: 109859244
NVI: 100117701
TCA: 658593
DPA: 109538612
NVL: 108565952
BMOR: 101741900
PMAC: 106715802
PRAP: 110994451
PXY: 105390704
API: 100164487
DNX: 107168462
ZNE: 110837483
CEL: CELE_Y37H9A.6(ndx-4)
CBR: CBG13634(Cbr-ndx-4)
BMY: Bm1_25505
TSP: Tsp_08826
CRG: 105345601
MYI: 110455017
OBI: 106872785
EPA: 110243084
HMG: 100200531
PIC: PICST_42119(HNT1)
PYO: PY17X_1238700(PY04487)
PCB: PCHAS_123590(PC000336.02.0)
BBO: BBOV_II002610(18.m06210)
NOC: Noc_1415
BME: BMEI0941
TTH: TT_C1859
PTO: PTO0464
 » show all
Taxonomy
Reference
1  [PMID:6309793]
  Authors
Jakubowski H, Guranowski A.
  Title
Enzymes hydrolyzing ApppA and/or AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds.
  Journal
J Biol Chem 258:9982-9 (1983)
Reference
2  [PMID:181087]
  Authors
Vallejo CG, Lobaton CD, Quintanilla M, Sillero A, Sillero MA.
  Title
Dinucleosidasetetraphosphatase in rat liver and Artemia salina.
  Journal
Biochim Biophys Acta 438:304-9 (1976)
DOI:10.1016/0005-2744(76)90246-1
Reference
3  [PMID:4955726]
  Authors
Warner AH, Finamore FJ.
  Title
Isolation, purification, and characterization of P1,P4-diguanosine 5'-tetraphosphate asymmetrical-pyrophosphohydrolase from brine shrimp eggs.
  Journal
Biochemistry 4:1568-75 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.17
IUBMB Enzyme Nomenclature: 3.6.1.17
ExPASy - ENZYME nomenclature database: 3.6.1.17
BRENDA, the Enzyme Database: 3.6.1.17
CAS: 37289-29-5

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