KEGG   ENZYME: 3.6.1.18Help
Entry
EC 3.6.1.18                 Enzyme                                 

Name
FAD diphosphatase;
FAD pyrophosphatase;
riboflavin adenine dinucleotide pyrophosphatase;
flavin adenine dinucleotide pyrophosphatase;
riboflavine adenine dinucleotide pyrophosphatase;
flavine adenine dinucleotide pyrophosphatase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
FAD nucleotidohydrolase
Reaction(IUBMB)
FAD + H2O = AMP + FMN [RN:R00160]
Reaction(KEGG)
Substrate
FAD [CPD:C00016];
H2O [CPD:C00001]
Product
AMP [CPD:C00020];
FMN [CPD:C00061]
Comment
The plant enzyme also hydrolyses NAD+ and NADH; the animal enzyme hydrolyses NAD+ and CoA at about half of the rate of hydrolysis of FAD. May be identical with EC 3.6.1.9 nucleotide diphosphatase.
History
EC 3.6.1.18 created 1972
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K18453  ADP-ribose/FAD diphosphatase
Genes
ATH: AT2G42070(NUDX23)
ALY: ARALYDRAFT_483292
CRB: 17887807
CSAT: 104782695 104785169 104793124
EUS: EUTSA_v10017043mg
BRP: 103858010 103866609
BNA: 106385468 106390989 106428102 106450637 111205779
BOE: 106329362 106339762
THJ: 104802583 104824477
CPAP: 110811796
CIT: 102624667
TCC: 18599110
GRA: 105799553
DZI: 111311580
EGR: 104425498
CAM: 101510027
LJA: Lj1g3v4327730.1(Lj1g3v4327730.1) Lj1g3v4327730.2(Lj1g3v4327730.2)
LANG: 109328857
FVE: 101313330
PPER: 18771727
PMUM: 103339411
PAVI: 110770737
PXB: 103958904
ZJU: 107409700
CSV: 101220971
CMO: 103486759
MCHA: 111024856
CMAX: 111481706
CMOS: 111441496
CPEP: 111790315
RCU: 8267074
JCU: 105646524
JRE: 109011950
VVI: 100245297
SLY: 101263980
SPEN: 107014865
SOT: 102605083
NSY: 104249700
NTO: 104089616
INI: 109180922
SIND: 105162491
LSV: 111908841
DCR: 108224652
BVG: 104889186
SOE: 110806030
NNU: 104603559
OSA: 4347801
DOSA: Os09t0553300-01(Os09g0553300)
OBR: 102702690
BDI: 100829230
ATS: 109772291(LOC109772291)
SBI: 8074182
SITA: 101755363
DCT: 110092687
AOF: 109850360
ATR: 18445418
PPP: 112289210
MNG: MNEG_7550
APRO: F751_4893
 » show all
Taxonomy
Reference
1  [PMID:5810832]
  Authors
Ravindranath SD, Rao NA.
  Title
Nucleotidases in plants. 3. Effect of metabolites on the enzyme hydrolyzing flavine adenine dinucleotide (FAD) from Phaseolus radiatus.
  Journal
Arch Biochem Biophys 133:54-9 (1969)
DOI:10.1016/0003-9861(69)90487-1
Reference
2  [PMID:2848456]
  Authors
Shin HJ, Mego JL.
  Title
A rat liver lysosomal membrane flavin-adenine dinucleotide phosphohydrolase: purification and characterization.
  Journal
Arch Biochem Biophys 267:95-103 (1988)
DOI:10.1016/0003-9861(88)90012-4
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.18
IUBMB Enzyme Nomenclature: 3.6.1.18
ExPASy - ENZYME nomenclature database: 3.6.1.18
BRENDA, the Enzyme Database: 3.6.1.18
CAS: 37289-30-8

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