KEGG   ENZYME: 3.6.1.52Help
Entry
EC 3.6.1.52                 Enzyme                                 

Name
diphosphoinositol-polyphosphate diphosphatase;
diphosphoinositol-polyphosphate phosphohydrolase;
DIPP
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
diphospho-myo-inositol-polyphosphate diphosphohydrolase
Reaction(IUBMB)
diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate [RN:R05777]
Reaction(KEGG)
Substrate
diphospho-myo-inositol polyphosphate [CPD:C11524];
H2O [CPD:C00001]
Product
myo-inositol polyphosphate [CPD:C11525];
phosphate [CPD:C00009]
Comment
This enzyme hydrolyses the diphosphate bond, leaving a phospho group where a diphospho group had been. It can also act on bis(adenosine) diphosphate.
History
EC 3.6.1.52 created 2002
Orthology
K07766  diphosphoinositol-polyphosphate diphosphatase
Genes
HSA: 11163(NUDT4) 11165(NUDT3) 170685(NUDT10) 55190(NUDT11)
PTR: 107971149 736394(NUDT4) 747254(NUDT3)
PPS: 100977832 100990151(NUDT4) 103782673(NUDT3)
GGO: 101137959 101139981(NUDT4) 101141171(NUDT11)
PON: 100172671(NUDT4) 100437513(NUDT3) 100443257 100443622
NLE: 100583670(NUDT10) 100584216(NUDT11) 100602253(NUDT4) 105737505(NUDT3)
MCC: 695921(NUDT10) 695959(NUDT11) 715385(NUDT4) 718568(NUDT3)
MCF: 101867035(NUDT4) 102136605(NUDT10) 102137860(NUDT11) 102140245(NUDT3)
CSAB: 103221638(NUDT3) 103231987 103231992 103238867(NUDT4)
RRO: 104658134(NUDT3) 104659100 104671374 104678599(NUDT4) 104680869
CJC: 100386206(NUDT4) 100393645(NUDT11) 100395066(NUDT3)
SBQ: 101029028(NUDT4) 101042229(NUDT3) 101051981(NUDT11)
MMU: 102954(Nudt10) 56409(Nudt3) 58242(Nudt11) 71207(Nudt4)
RNO: 294292(Nudt3) 367747(Nudt10) 680248(Nudt11) 94267(Nudt4)
CGE: 100753131(Nudt4) 100758392 103158569(Nudt3)
NGI: 103726310(Nudt4) 103730281(Nudt11) 103730283 103739686(Nudt3)
HGL: 101698372 101699580(Nudt11) 101719214(Nudt4) 106007569(Nudt3)
OCU: 100353515(NUDT4) 100356460(NUDT3) 100357181(NUDT11)
TUP: 102470236(NUDT3) 102478628(NUDT4) 102481545
CFA: 100846983(NUDT3) 475425(NUDT4) 491890 612593(NUDT11)
AML: 100466960 100476316(NUDT4) 100483072(NUDT3)
UMR: 103660151(NUDT4) 103665476(NUDT3) 103679799
PTG: 102948957 102953417(NUDT4) 102971995(NUDT3)
BTA: 531462 614183(NUDT4) 616931(NUDT10) 618855(NUDT3) 785611(NUDT11)
BOM: 102269040(NUDT4) 102278529(NUDT11) 102278805 102286560 102287050(NUDT3)
BIU: 109554982 109555566(NUDT11) 109558977(NUDT4) 109576553(NUDT3)
PHD: 102344185(NUDT4)
CHX: 102173088(NUDT11) 102175468(NUDT4) 106503475(NUDT3) 108634362
OAS: 101106320(NUDT4) 101115995(NUDT3) 101122836(NUDT11) 101123095
SSC: 100515984 100519192(NUDT4) 100624768(NUDT11) 100737442(NUDT3)
CFR: 102519656(NUDT4) 102521473 102523571(NUDT3)
CDK: 105097409(NUDT4) 105101427(NUDT3) 105104372
BACU: 103003839 103011181(NUDT3) 103019513(NUDT4)
OOR: 101282135(NUDT11) 101290203(NUDT4) 105747712(NUDT3)
ECB: 100064437(NUDT4) 102149351(NUDT3) 111771498(NUDT11)
EAI: 106831181(NUDT4) 106834632(NUDT3) 106841503
MYB: 102238974 102256161(NUDT3) 102262001(NUDT4)
MYD: 102757376(NUDT3) 102766076(NUDT4) 102769935(NUDT10)
HAI: 109378698 109392433(NUDT3) 109392666(NUDT4)
PALE: 102880716 102881951(NUDT3) 102888374(NUDT4)
MDO: 100015435(NUDT4) 103106377(NUDT3)
SHR: 100916829 100924844(NUDT4)
OAA: 100073927(NUDT4) 100088959(NUDT3)
GGA: 417897(NUDT4) 419905(NUDT3)
MGP: 100545556(NUDT4) 104914525(NUDT3)
CJO: 107311562(NUDT4) 107324877(NUDT3)
APLA: 101792327(NUDT3) 101805371(NUDT4)
ACYG: 106036958(NUDT4)
TGU: 100189960(NUDT4) 105758884(NUDT3)
GFR: 102031445(NUDT4) 102035887(NUDT3)
FAB: 101807912(NUDT3) 101815641(NUDT4)
PHI: 102110920(NUDT3) 102113614(NUDT4)
PMAJ: 107205033(NUDT4) 107214886(NUDT3)
CCAE: 111933677(NUDT4) 111939754(NUDT3)
CCW: 104692382(NUDT3) 104696451(NUDT4)
FPG: 101910592(NUDT3) 101915353(NUDT4)
FCH: 102046910(NUDT4) 106631672(NUDT3)
CLV: 102096810(NUDT4) 102097363(NUDT3)
EGZ: 104125718(NUDT3) 104132332(NUDT4)
AAM: 106488865(NUDT4) 106490937(NUDT3)
ASN: 102368135(NUDT4) 102381897
AMJ: 102566648(NUDT3) 102573038(NUDT4)
PSS: 102459907(NUDT4)
CMY: 102938043(NUDT3) 102946204(NUDT4)
CPIC: 101941459(NUDT4) 101941804 101946559(NUDT3)
ACS: 100560847(nudt4) 100563275
PVT: 110080266(NUDT3) 110091725(NUDT4)
PBI: 103049834(NUDT4) 103066873(NUDT3)
GJA: 107118669(NUDT4) 107121113(NUDT3)
XLA: 447697 495434(nudt4.S)
XTR: 448180(nudt4)
NPR: 108790056(NUDT4) 108790372(NUDT3)
DRE: 378990(nudt4a) 394120(nudt3a) 447910(nudt4b) 450013(nudt3b)
IPU: 108264787(nudt4) 108271898(NUDT3) 108275142
AMEX: 103022980(nudt4) 103028168 103041194(nudt3)
LCO: 104924368(nudt4) 104928309(nudt3) 104933915
NCC: 104951656 104954421(nudt4) 104965609(nudt3)
PRET: 103459410(nudt4) 103464722(nudt3) 103466095
SFM: 108927819 108933906(nudt4) 108939357(nudt3)
LCM: 102357558(NUDT4) 102363264(NUDT3)
CMK: 103176815 103179115(nudt3) 103188877(nudt4)
CIN: 104265877
SPU: 588851
SKO: 100370677
DME: Dmel_CG6391(Aps)
DSI: Dsimw501_GD17584(Dsim_GD17584)
MDE: 101898577
AAG: 5578753
AME: 409489
BIM: 100748134
BTER: 100645582
SOC: 105207994
AEC: 105154514
ACEP: 105619462
PBAR: 105433884
HST: 105191009
DQU: 106741782
CFO: 105249136
LHU: 105677470
PGC: 109857934
PCF: 106784030
NVI: 100115583
MDL: 103568199
TCA: 656747
NVL: 108566945
BMOR: 101744978
PMAC: 106720777
PRAP: 111003440
HAW: 110375550
API: 100161516
DNX: 107165759
CLEC: 106666018
ZNE: 110830009
TUT: 107369081
CEL: CELE_R119.3(R119.3) CELE_Y92H12BL.5(Y92H12BL.5)
BMY: Bm1_57405
TSP: Tsp_12014
CRG: 105340435
MYI: 110445170
LAK: 106180126
EPA: 110246604
HMG: 105846261
ATH: AT1G73540(NUDT21)
LJA: Lj0g3v0079109.1(Lj0g3v0079109.1) Lj0g3v0201549.1(Lj0g3v0201549.1) Lj0g3v0296919.1(Lj0g3v0296919.1) Lj1g3v3930310.1(Lj1g3v3930310.1) Lj1g3v3930310.2(Lj1g3v3930310.2) Lj1g3v3930310.3(Lj1g3v3930310.3) Lj1g3v3930310.4(Lj1g3v3930310.4) Lj1g3v3930310.5(Lj1g3v3930310.5) Lj2g3v0658260.1(Lj2g3v0658260.1) Lj3g3v1907670.1(Lj3g3v1907670.1) Lj4g3v3113010.1(Lj4g3v3113010.1) Lj6g3v0340630.1(Lj6g3v0340630.1) Lj6g3v0410600.1(Lj6g3v0410600.1)
DOSA: Os02t0520100-01(Os02g0520100) Os02t0734300-01(Os02g0734300) Os03t0810300-01(Os03g0810300) Os04t0399300-01(Os04g0399300) Os06t0255400-01(Os06g0255400) Os07t0212300-01(Os07g0212300) Os11t0531700-01(Os11g0531700)
ATS: 109755599(LOC109755599) 109769410(LOC109769410) 109774553(LOC109774553) 109777735(LOC109777735) 109784496(LOC109784496)
APRO: F751_2735
SCE: YOR163W(DDP1)
ERC: Ecym_3128
KMX: KLMA_40184(DDP1)
NCS: NCAS_0F00300(NCAS0F00300)
NDI: NDAI_0K02830(NDAI0K02830)
TPF: TPHA_0J00610(TPHA0J00610)
TBL: TBLA_0E03250(TBLA0E03250)
TDL: TDEL_0G04120(TDEL0G04120)
KAF: KAFR_0G02550(KAFR0G02550)
PIC: PICST_60333(DDP1)
CAL: CAALFM_C502220CA(CaO19.4229)
CAUR: QG37_06231
NCR: NCU01804
NTE: NEUTE1DRAFT65267(NEUTE1DRAFT_65267)
MGR: MGG_06680
SSCK: SPSK_01980
MAW: MAC_03539
MAJ: MAA_02648
CMT: CCM_02457
BFU: BCIN_14g04700(Bcddp1)
MBE: MBM_09091
ANI: AN6251.2
ANG: ANI_1_244024(An02g01790)
TVE: TRV_06868
PTE: PTT_16466
SPO: SPAC13G6.14(aps1)
ABP: AGABI1DRAFT85717(AGABI1DRAFT_85717)
ABV: AGABI2DRAFT134904(AGABI2DRAFT_134904)
MGL: MGL_0427
 » show all
Taxonomy
Reference
1  [PMID:9822604]
  Authors
Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB.
  Title
A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase.
  Journal
EMBO J 17:6599-607 (1998)
DOI:10.1093/emboj/17.22.6599
  Sequence
[hsa:11165]
Reference
2  [PMID:10777568]
  Authors
Caffrey JJ, Safrany ST, Yang X, Shears SB.
  Title
Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family.
  Journal
J Biol Chem 275:12730-6 (2000)
DOI:10.1074/jbc.275.17.12730
  Sequence
[hsa:11163]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.52
IUBMB Enzyme Nomenclature: 3.6.1.52
ExPASy - ENZYME nomenclature database: 3.6.1.52
BRENDA, the Enzyme Database: 3.6.1.52

KEGG   ENZYME: 3.6.1.60Help
Entry
EC 3.6.1.60                 Enzyme                                 

Name
diadenosine hexaphosphate hydrolase (AMP-forming);
hAps1;
NUDT11 (gene name);
hAps2;
NUDT10 (gene name)
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (AMP-forming)
Reaction(IUBMB)
(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = adenosine 5'-pentaphosphate + AMP [RN:R09881];
(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = adenosine 5'-tetraphosphate + AMP [RN:R09882]
Reaction(KEGG)
Substrate
P1,P6-bis(5'-adenosyl)hexaphosphate [CPD:C20190];
H2O [CPD:C00001];
P1,P5-bis(5'-adenosyl)pentaphosphate [CPD:C04058]
Product
adenosine 5'-pentaphosphate [CPD:C20198];
AMP [CPD:C00020];
adenosine 5'-tetraphosphate [CPD:C03483]
Comment
A divalent cation is essential for activity. Mn2+ (2--6 mM) is most effective.
The enzyme controls intracellular levels of P1,P5-bis(5'-adenosyl)pentaphosphate and P1,P6-bis(5'-adenosyl)hexaphosphate. Weak activity with P1,P4-bis(5'-adenosyl)tetraphosphate. Marked preference for adenine over guanine nucleotides.
History
EC 3.6.1.60 created 2012
Reference
1  [PMID:12121577]
  Authors
Leslie NR, McLennan AG, Safrany ST
  Title
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases.
  Journal
BMC Biochem 3:20 (2002)
  Sequence
Reference
2  [PMID:10419486]
  Authors
Safrany ST, Ingram SW, Cartwright JL, Falck JR, McLennan AG, Barnes LD, Shears SB
  Title
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein.
  Journal
J Biol Chem 274:21735-40 (1999)
DOI:10.1074/jbc.274.31.21735
  Sequence
[sce:YOR163W]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.60
IUBMB Enzyme Nomenclature: 3.6.1.60
ExPASy - ENZYME nomenclature database: 3.6.1.60
BRENDA, the Enzyme Database: 3.6.1.60

DBGET integrated database retrieval system