KEGG   ENZYME: 3.6.1.53Help
Entry
EC 3.6.1.53                 Enzyme                                 

Name
Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase;
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase;
ADPRibase-Mn
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
CDP-choline phosphohydrolase
Reaction(IUBMB)
(1) CDP-choline + H2O = CMP + phosphocholine [RN:R09538];
(2) ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate [RN:R01054]
Reaction(KEGG)
Substrate
CDP-choline [CPD:C00307];
H2O [CPD:C00001];
ADP-D-ribose [CPD:C00301]
Product
CMP [CPD:C00055];
phosphocholine [CPD:C00588];
AMP [CPD:C00020];
D-ribose 5-phosphate [CPD:C00117]
Comment
Requires Mn2+. Unlike EC 3.6.1.13, ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed [2]. The mammalian enzyme hydrolyses cyclic ADP-ribose to 1-(5-phospho-beta-D-ribosyl)-AMP with ~100-fold lower efficiency than ADP-D-ribose [3]. In rat, the enzyme is found predominantly in thymus and spleen.
History
EC 3.6.1.53 created 2008
Orthology
K01517  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Genes
HSA: 56985(ADPRM)
PTR: 745728(ADPRM)
PPS: 100989248(ADPRM)
GGO: 101139187(ADPRM)
PON: 100436862(ADPRM)
NLE: 100601662(ADPRM)
MCC: 717991(ADPRM)
MCF: 102147209(ADPRM)
CSAB: 103242388(ADPRM)
RRO: 104675129(ADPRM)
RBB: 108520319(ADPRM)
CJC: 100399298(ADPRM)
SBQ: 101035686(ADPRM)
MMU: 66358(Adprm)
RNO: 287406(Adprm)
CGE: 100767531(Adprm)
NGI: 103752060(Adprm)
HGL: 101700336(Adprm)
CCAN: 109697084(Adprm)
OCU: 100350105(ADPRM)
TUP: 102478915(ADPRM)
CFA: 479504(ADPRM)
AML: 100484618(ADPRM)
UMR: 103660405(ADPRM)
ORO: 101374847(ADPRM)
FCA: 101085161(ADPRM)
PTG: 102965979(ADPRM)
AJU: 106983330(ADPRM)
BTA: 534038(ADPRM)
BOM: 102283155(ADPRM)
BIU: 109573878(ADPRM)
PHD: 102324948(ADPRM)
CHX: 102181988(ADPRM)
OAS: 101113772(ADPRM)
SSC: 100519388(ADPRM)
CFR: 102511144(ADPRM)
CDK: 105095885(ADPRM)
BACU: 103010454(ADPRM)
LVE: 103089607(ADPRM)
OOR: 101271746(ADPRM)
ECB: 100073085(ADPRM)
EPZ: 103557154(ADPRM)
EAI: 106845767(ADPRM)
MYB: 102260362(ADPRM)
MYD: 102759013(ADPRM) 102769086
HAI: 109389128(ADPRM)
RSS: 109460156(ADPRM)
PALE: 102882253(ADPRM)
LAV: 100672645(ADPRM)
TMU: 101361939
MDO: 100031391(ADPRM)
SHR: 100918137(ADPRM)
OAA: 100089526(ADPRM)
GGA: 768578(ADPRM)
MGP: 100544671(ADPRM)
CJO: 107321978(ADPRM)
APLA: 101805114(ADPRM)
TGU: 100232304(ADPRM)
GFR: 102037693(ADPRM)
FAB: 101822214(ADPRM)
PHI: 102102216(ADPRM)
PMAJ: 107212591(ADPRM)
CCW: 104695677(ADPRM)
FPG: 101917811(ADPRM)
FCH: 102046962(ADPRM)
CLV: 102096818(ADPRM)
AAM: 106496876(ADPRM)
ASN: 102378502(ADPRM)
AMJ: 102564317(ADPRM)
PSS: 102454910(ADPRM)
CMY: 102947863(ADPRM)
CPIC: 101938771(ADPRM)
ACS: 100557018(adprm)
PVT: 110075038(ADPRM)
PBI: 103062440(ADPRM)
XLA: 108701161 380120(adprm.L)
XTR: 100498212 493375(adprm)
NPR: 108800850 108801529(ADPRM)
DRE: 393393(adprm)
SANH: 107653999(adprm)
SGH: 107556466(adprm)
IPU: 108274373(adprm)
LCO: 104919483(adprm)
NCC: 104963227(adprm)
MZE: 101478096(adprm)
XMA: 102227889(adprm)
PRET: 103481918(adprm)
CSEM: 103382417(adprm)
LCF: 108890898(adprm)
HCQ: 109512603(adprm)
BPEC: 110154055(adprm)
SASA: 106589237(adprm)
ELS: 105023010(adprm)
SFM: 108939934(adprm)
LCM: 102354487(ADPRM)
CMK: 103175697(adprm)
SKO: 100369075
TUT: 107361847
CRG: 105341087
OBI: 106867761
LAK: 106161328
EPA: 110231729
ADF: 107346478
ATH: AT4G24730
CRB: 17878964
BRP: 108868780
THJ: 104824991
CPAP: 110814750
CIT: 102626985
TCC: 18604977
DZI: 111284677
EGR: 104417636
LJA: Lj0g3v0335139.2(Lj0g3v0335139.2) Lj4g3v1415260.1(Lj4g3v1415260.1)
FVE: 101314949
PPER: 18777900
PMUM: 103337949
PAVI: 110745894
MDM: 103455068
PXB: 103952940
ZJU: 107418316
CSV: 101207870
CMO: 103483938
MCHA: 111009099
CMOS: 111431448
RCU: 8278270
JCU: 105640292
HBR: 110648058
POP: 7484431
JRE: 108986726
VVI: 100265684
SLY: 101246124
SPEN: 107012378
SOT: 102587466
CANN: 107862601
INI: 109180078
LSV: 111907042
DCR: 108206584
BVG: 104884525
SOE: 110802382
NNU: 104591517
OSA: 4344352
DOSA: Os07t0688000-01(Os07g0688000) Os08t0557200-01(Os08g0557200)
OBR: 102712498
ATS: 109779171(LOC109779171) 109779172(LOC109779172) 109782101(LOC109782101)
PDA: 103719827
EGU: 105052964
MUS: 103970733
DCT: 110114792
ATR: 18442745
APRO: F751_1456
SMIN: v1.2.028698.t1(symbB.v1.2.028698.t1)
SPAR: SPRG_19962
 » show all
Taxonomy
Reference
1  [PMID:7819284]
  Authors
Canales J, Pinto RM, Costas MJ, Hernandez MT, Miro A, Bernet D, Fernandez A, Cameselle JC
  Title
Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatases different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg(2+)-and/or Mn(2+)-dependent hydrolases acting on ADP-ribose.
  Journal
Biochim Biophys Acta 1246:167-77 (1995)
DOI:10.1016/0167-4838(94)00191-I
Reference
2  [PMID:18352857]
  Authors
Canales J, Fernandez A, Ribeiro JM, Cabezas A, Rodrigues JR, Cameselle JC, Costas MJ
  Title
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells.
  Journal
Biochem J 413:103-13 (2008)
DOI:10.1042/BJ20071471
  Sequence
[rno:287406]
Reference
3  [PMID:19379742]
  Authors
Canales J, Fernandez A, Rodrigues JR, Ferreira R, Ribeiro JM, Cabezas A, Costas MJ, Cameselle JC
  Title
Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase.
  Journal
FEBS Lett 583:1593-8 (2009)
DOI:10.1016/j.febslet.2009.04.023
  Sequence
[rno:287406]
Reference
4  [PMID:22848751]
  Authors
Rodrigues JR, Fernandez A, Canales J, Cabezas A, Ribeiro JM, Costas MJ, Cameselle JC
  Title
Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.
  Journal
PLoS One 7:e42249 (2012)
DOI:10.1371/journal.pone.0042249
  Sequence
[dre:393393]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.53
IUBMB Enzyme Nomenclature: 3.6.1.53
ExPASy - ENZYME nomenclature database: 3.6.1.53
BRENDA, the Enzyme Database: 3.6.1.53

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