KEGG   ENZYME: 3.6.1.56Help
Entry
EC 3.6.1.56                 Enzyme                                 

Name
2-hydroxy-dATP diphosphatase;
NUDT1;
MTH1;
MTH2;
oxidized purine nucleoside triphosphatase;
(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
2-hydroxy-dATP diphosphohydrolase
Reaction(IUBMB)
2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate [RN:R09833]
Reaction(KEGG)
Substrate
2-hydroxy-dATP [CPD:C19969];
H2O [CPD:C00001]
Product
2-hydroxy-dAMP [CPD:C19970];
diphosphate [CPD:C00013]
Comment
The enzyme hydrolyses oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [3].
History
EC 3.6.1.56 created 2011
Orthology
K17816  8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase
Genes
HSA: 4521(NUDT1)
PTR: 463225(NUDT1)
PPS: 100976009(NUDT1)
GGO: 101142144(NUDT1)
PON: 100453694(NUDT1)
NLE: 100588684(NUDT1)
MCC: 713078(NUDT1)
MCF: 102115722(NUDT1)
CSAB: 103246873(NUDT1)
RRO: 104664957(NUDT1)
RBB: 108543779(NUDT1)
CJC: 100403627(NUDT1)
SBQ: 101051836(NUDT1)
MMU: 17766(Nudt1)
RNO: 117260(Nudt1)
CGE: 100770207(Nudt1)
NGI: 103748680(Nudt1)
HGL: 101712324(Nudt1)
CCAN: 109675365(Nudt1)
OCU: 100348373(NUDT1)
CFA: 489894(NUDT1)
AML: 100478273(NUDT1)
UMR: 103669938(NUDT1)
ORO: 101368391(NUDT1)
FCA: 101091068(NUDT1)
PTG: 102960769(NUDT1)
AJU: 106984517(NUDT1)
BTA: 525496(NUDT1)
BOM: 102283912(NUDT1)
BIU: 109578390(NUDT1)
PHD: 102324548(NUDT1)
CHX: 102170291(NUDT1)
OAS: 101119103(NUDT1)
SSC: 100624718(NUDT1)
CFR: 102505397(NUDT1)
CDK: 105105774(NUDT1)
BACU: 102999519(NUDT1)
LVE: 103088420(NUDT1)
OOR: 101283489(NUDT1)
ECB: 100059629(NUDT1)
EPZ: 103551753(NUDT1)
EAI: 106834772(NUDT1)
MYB: 102258594(NUDT1)
MYD: 102773538(NUDT1)
HAI: 109380216(NUDT1)
RSS: 109461368(NUDT1)
LAV: 100654813(NUDT1)
TMU: 101353850
MDO: 100029290(NUDT1)
SHR: 100930683(NUDT1)
OAA: 100084923
GGA: 416467(NUDT1)
MGP: 100549281 104913432(NUDT1)
CJO: 107320710 107320712(NUDT1)
APLA: 101796502(NUDT1)
ACYG: 106033546(NUDT1)
TGU: 100219364(NUDT1)
GFR: 102043288(NUDT1)
FAB: 101817554(NUDT1)
PHI: 102103488(NUDT1)
PMAJ: 107211267(NUDT1)
CCAE: 111936088(NUDT1)
CCW: 104684817(NUDT1)
FPG: 101910266(NUDT1)
FCH: 102058149(NUDT1)
CLV: 102089493(NUDT1)
EGZ: 104132589(NUDT1)
AAM: 106499956(NUDT1)
ASN: 102382097(NUDT1)
AMJ: 102569822(NUDT1)
PSS: 102462474(NUDT1)
CMY: 102932983(NUDT1)
CPIC: 101953878(NUDT1)
ACS: 100564610(nudt1)
PVT: 110084701(NUDT1)
PBI: 103052574(NUDT1)
GJA: 107119570(NUDT1)
XLA: 108703127(nudt1.S)
XTR: 448146(nudt1)
DRE: 406727(nudt1)
SRX: 107753577(nudt1) 107758325
SGH: 107581785(nudt1) 107592807
CCAR: 109056023(nudt1)
IPU: 108257246(nudt1)
AMEX: 103022352(nudt1)
TRU: 101067910(nudt1)
LCO: 104918728 109139217(nudt1)
NCC: 104964484(nudt1)
MZE: 101466444(nudt1)
OLA: 101169700(nudt1)
XMA: 102231230(nudt1)
NFU: 107378429(nudt1)
KMR: 108246142(nudt1)
CSEM: 103392620(nudt1)
LCF: 108900758(nudt1)
SDU: 111217653(nudt1)
HCQ: 109513790(nudt1)
BPEC: 110169430(nudt1)
MALB: 109964239(nudt1)
SASA: 100195837(nudt1)
OTW: 112226028 112245990(nudt1)
ELS: 105013216(nudt1)
SFM: 108922561(nudt1)
LCM: 102349971(NUDT1)
CMK: 103186606(nudt1)
SPU: 587752
APLC: 110978627
AME: 410765
BIM: 100744348
BTER: 100648023
NVI: 100120426
TCA: 660792
BMOR: 101739539
PMAC: 106721409
PRAP: 111000748
HAW: 110382494
PXY: 105383187
API: 100163724
DNX: 107163411
CLEC: 106670004
ZNE: 110832773
MYI: 110448564
OBI: 106871882
LAK: 106172379
EPA: 110251770
ADF: 107332051
HMG: 100204562
AQU: 100633071
ATR: 18444160
ABP: AGABI1DRAFT108808(AGABI1DRAFT_108808)
ABV: AGABI2DRAFT187240(AGABI2DRAFT_187240)
DFA: DFA_07569
VRM: 44547418_01756(mutX)
MARH: Mia14_0394
 » show all
Taxonomy
Reference
1  [PMID:8226881]
  Authors
Sakumi K, Furuichi M, Tsuzuki T, Kakuma T, Kawabata S, Maki H, Sekiguchi M
  Title
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.
  Journal
J Biol Chem 268:23524-30 (1993)
  Sequence
[hsa:4521]
Reference
2  [PMID:7592783]
  Authors
Kakuma T, Nishida J, Tsuzuki T, Sekiguchi M
  Title
Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution.
  Journal
J Biol Chem 270:25942-8 (1995)
DOI:10.1074/jbc.270.43.25942
  Sequence
[mmu:17766]
Reference
3  [PMID:10373420]
  Authors
Fujikawa K, Kamiya H, Yakushiji H, Fujii Y, Nakabeppu Y, Kasai H
  Title
The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein.
  Journal
J Biol Chem 274:18201-5 (1999)
DOI:10.1074/jbc.274.26.18201
  Sequence
[hsa:4521]
Reference
4  [PMID:11756418]
  Authors
Sakai Y, Furuichi M, Takahashi M, Mishima M, Iwai S, Shirakawa M, Nakabeppu Y
  Title
A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP  by human MTH1.
  Journal
J Biol Chem 277:8579-87 (2002)
DOI:10.1074/jbc.M110566200
  Sequence
[hsa:4521]
Reference
5  [PMID:11139615]
  Authors
Fujikawa K, Kamiya H, Yakushiji H, Nakabeppu Y, Kasai H
  Title
Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.
  Journal
Nucleic Acids Res 29:449-54 (2001)
DOI:10.1093/nar/29.2.449
  Sequence
[hsa:4521]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.56
IUBMB Enzyme Nomenclature: 3.6.1.56
ExPASy - ENZYME nomenclature database: 3.6.1.56
BRENDA, the Enzyme Database: 3.6.1.56

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