KEGG   ENZYME: 3.6.1.58Help
Entry
EC 3.6.1.58                 Enzyme                                 

Name
8-oxo-dGDP phosphatase;
NUDT5;
MTH3 (gene name);
NUDT18
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
8-oxo-dGDP phosphohydrolase
Reaction(IUBMB)
8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate [RN:R09877]
Reaction(KEGG)
Substrate
8-oxo-dGDP [CPD:C20176];
H2O [CPD:C00001]
Product
8-oxo-dGMP [CPD:C19968];
phosphate [CPD:C00009]
Comment
The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage. The preferred in vivo substrate is not known. The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [1,2]. Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolysed with broad specificity. The bifunctional enzyme NUDT5 also hydrolyses ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13, ADP-ribose diphosphatase) [4]. The human enzyme NUDT18 also hydrolyses 8-oxo-dADP and 2-hydroxy-dADP, the latter at a slower rate [6].
History
EC 3.6.1.58 created 2012
Orthology
K13987  ADP-sugar pyrophosphatase / 8-oxo-dGDP phosphatase / ADP-D-ribose pyrophosphorylase
K17817  8-oxo-dGDP phosphatase
Genes
HSA: 11164(NUDT5) 79873(NUDT18)
PTR: 450306(NUDT5) 741929(NUDT18)
PPS: 100977496(NUDT18) 100977876(NUDT5)
GGO: 101132071(NUDT18) 101148720(NUDT5)
PON: 100172071(NUDT5) 100451093(NUDT18)
NLE: 100594282(NUDT18) 100600434(NUDT5)
MCC: 694368(NUDT5) 707061(NUDT18)
MCF: 102118162(NUDT5) 102138807(NUDT18)
CSAB: 103215715(NUDT18) 103237893(NUDT5)
RRO: 104663986(NUDT18) 104664884(NUDT5)
RBB: 108521324(NUDT18) 108538530(NUDT5)
CJC: 100388611(NUDT18) 100414997(NUDT5)
SBQ: 101035792(NUDT5) 101041775(NUDT18)
MMU: 213484(Nudt18) 53893(Nudt5)
RNO: 361068(Nudt18) 361274(Nudt5)
CGE: 100765600(Nudt18) 100772118(Nudt5)
NGI: 103738702(Nudt5) 103747768(Nudt18) 108491232
HGL: 101710430(Nudt18) 101722031(Nudt5)
CCAN: 109682446(Nudt5) 109690459(Nudt18)
OCU: 100341885(NUDT5) 100357274(NUDT18)
TUP: 102479208(NUDT18) 102481118(NUDT5)
CFA: 478006(NUDT5) 609139(NUDT18)
AML: 100473859(NUDT18) 100482621(NUDT5)
UMR: 103673345(NUDT18) 103676270(NUDT5)
ORO: 101364423(NUDT5) 101380890(NUDT18)
FCA: 101084635(NUDT5) 101090347(NUDT18)
PTG: 102950979(NUDT5) 102972039(NUDT18)
AJU: 106971034(NUDT5) 106981091(NUDT18)
BTA: 509535(NUDT18) 614149(NUDT5)
BOM: 102283030(NUDT5) 102284141(NUDT18)
BIU: 109562537(NUDT18) 109567873(NUDT5)
PHD: 102331579(NUDT5) 102341737(NUDT18)
CHX: 102174220(NUDT5) 102178907(NUDT18)
OAS: 101117473(NUDT18) 101117779(NUDT5)
SSC: 100156061(NUDT18) 100511529(NUDT5)
CFR: 102506081(NUDT5) 102521795(NUDT18)
CDK: 105100309(NUDT5) 105102746(NUDT18)
BACU: 103014516(NUDT5) 103015615(NUDT18)
LVE: 103088541(NUDT5) 103089589(NUDT18)
OOR: 101271940(NUDT5) 101288904(NUDT18)
ECB: 100056631(NUDT18) 100056812(NUDT5)
EPZ: 103563355(NUDT5) 103566265(NUDT18)
EAI: 106826880 106836935(NUDT5) 106847697(NUDT18)
MYB: 102243782(NUDT5) 102258993(NUDT18)
MYD: 102755333(NUDT5) 102755914(NUDT18)
HAI: 109382362(NUDT18) 109390483(NUDT5)
RSS: 109433767(NUDT5) 109436030(NUDT18)
PALE: 102895562(NUDT5) 102895707(NUDT18)
LAV: 100675481(NUDT18) 100677273(NUDT5)
MDO: 100013664(NUDT5) 100033092(NUDT18)
SHR: 100913469(NUDT18) 100926504(NUDT5)
OAA: 100084986(NUDT5) 100087230(NUDT18)
GGA: 426368(NUDT5)
MGP: 100538350(NUDT5)
CJO: 107317497(NUDT5) 107323725(NUDT18)
APLA: 101792445(NUDT5)
ACYG: 106046205(NUDT5)
TGU: 100227819(NUDT5)
GFR: 102042579(NUDT5)
FAB: 101811306(NUDT5) 107604323(NUDT18)
PHI: 102100920(NUDT5) 102114450(NUDT18)
PMAJ: 107204378(NUDT5) 107213979(NUDT18)
CCAE: 111923119(NUDT5)
CCW: 104694502(NUDT5)
FPG: 101911346(NUDT5) 101919411(NUDT18)
FCH: 102050796(NUDT18) 102058952(NUDT5)
CLV: 102084865(NUDT5) 102095789(NUDT18)
EGZ: 104135774(NUDT5)
AAM: 106485164(NUDT18) 106485418(NUDT5)
ASN: 102373059(NUDT5) 102382475(NUDT18)
AMJ: 102562108(NUDT5) 102572685(NUDT18)
PSS: 102447968(NUDT18) 102460805(NUDT5)
CMY: 102935770(NUDT18) 102941929(NUDT5)
CPIC: 101936689(NUDT18) 101938331(NUDT5)
ACS: 100558579(nudt18) 100567214(nudt5)
PVT: 110072074(NUDT18) 110081210(NUDT5)
PBI: 103062314(NUDT18) 103064447(NUDT5)
GJA: 107111067(NUDT5) 107120358(NUDT18)
XLA: 108712701(nudt18.S) 108713048(nudt5.S) 432263(nudt5.L)
XTR: 100488091(nudt18) 549367(nudt5)
NPR: 108784813(NUDT5) 108798459(NUDT18)
DRE: 415176(nudt5) 550541(nudt18)
IPU: 100528701(nudt5) 108265859(nudt18)
AMEX: 103022158(nudt18) 103033374(nudt5)
TRU: 101067864(nudt18)
LCO: 104930602(nudt5) 104936536(nudt18)
NCC: 104955336(nudt5) 104957221 104957701(nudt18)
MZE: 101470680(nudt5) 101476216(nudt18)
OLA: 101160293(nudt18) 101161229(nudt5)
XMA: 102224507(nudt5) 102236783(nudt18)
PRET: 103459674(nudt5) 103470797(nudt18)
NFU: 107382591(nudt5) 107386149(nudt18)
KMR: 108245546(nudt5) 108245838(nudt18)
CSEM: 103383109(nudt5) 103398016(nudt18)
LCF: 108874307(nudt5) 108875363(nudt18) 108891412
SDU: 111224766(nudt5) 111236953(nudt18)
HCQ: 109525316(nudt18) 109528866(nudt5)
BPEC: 110161767(nudt5) 110162096(nudt18)
MALB: 109957397(nudt18) 109960917(nudt5)
SASA: 100196024(nudt5) 106587023(nudt18) 106609278(NUDT5)
OTW: 112216934 112248922(nudt18)
ELS: 105028521(nudt5) 105031473(nudt18)
SFM: 108929536(nudt18) 108931529(nudt5)
LCM: 102346525(NUDT18) 102359306(NUDT5)
CMK: 103173152(nudt18) 103187912(nudt5)
DME: Dmel_CG10898(CG10898)
DSI: Dsimw501_GD18763(Dsim_GD18763)
MDE: 101888835
AAG: 5569095
AME: 413933
BIM: 100742493
BTER: 100648588
SOC: 105199750
AEC: 105148604
ACEP: 105620493
PBAR: 105427990
HST: 105182173
DQU: 106747881
CFO: 105256419
LHU: 105670594
PGC: 109859396
PCF: 106784337
NVI: 100124005
MDL: 103570262
TCA: 656819
DPA: 109546344
NVL: 108569754
BMOR: 101740661
PMAC: 106713793
PRAP: 110998304
HAW: 110370267
PXY: 105381986
API: 100164703
DNX: 107165316
CLEC: 106672324
CEL: CELE_T26E3.2(ndx-1)
CBR: CBG08712(Cbr-ndx-1)
MYI: 110448861
EPA: 110246095
ADF: 107345269
AQU: 100631490
SPAR: SPRG_01817
 » show all
Taxonomy
Reference
1  [PMID:16002790]
  Authors
Ishibashi T, Hayakawa H, Ito R, Miyazawa M, Yamagata Y, Sekiguchi M
  Title
Mammalian enzymes for preventing transcriptional errors caused by oxidative damage.
  Journal
Nucleic Acids Res 33:3779-84 (2005)
DOI:10.1093/nar/gki682
  Sequence
[hsa:11164]
Reference
2  [PMID:12717453]
  Authors
Ishibashi T, Hayakawa H, Sekiguchi M
  Title
A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.
  Journal
EMBO Rep 4:479-83 (2003)
DOI:10.1038/sj.embor.embor838
  Sequence
[hsa:11164]
Reference
3  [PMID:19699693]
  Authors
Kamiya H, Hori M, Arimori T, Sekiguchi M, Yamagata Y, Harashima H
  Title
NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity.
  Journal
DNA Repair (Amst) 8:1250-4 (2009)
DOI:10.1016/j.dnarep.2009.07.011
Reference
4  [PMID:21389046]
  Authors
Ito R, Sekiguchi M, Setoyama D, Nakatsu Y, Yamagata Y, Hayakawa H
  Title
Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein.
  Journal
J Biochem 149:731-8 (2011)
DOI:10.1093/jb/mvr028
Reference
5  [PMID:17052728]
  Authors
Zha M, Zhong C, Peng Y, Hu H, Ding J
  Title
Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity.
  Journal
J Mol Biol 364:1021-33 (2006)
DOI:10.1016/j.jmb.2006.09.078
  Sequence
[hsa:11164]
Reference
6  [PMID:22556419]
  Authors
Takagi Y, Setoyama D, Ito R, Kamiya H, Yamagata Y, Sekiguchi M
  Title
Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.
  Journal
J Biol Chem 287:21541-9 (2012)
DOI:10.1074/jbc.M112.363010
  Sequence
[hsa:79873]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.58
IUBMB Enzyme Nomenclature: 3.6.1.58
ExPASy - ENZYME nomenclature database: 3.6.1.58
BRENDA, the Enzyme Database: 3.6.1.58

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