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Entry
EC 3.6.1.59                 Enzyme                                 

Name
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;
DcpS;
m7GpppX pyrophosphatase;
m7GpppN m7GMP phosphohydrolase;
m7GpppX diphosphatase;
m7G5'ppp5'N m7GMP phosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] N7-methylguanosine 5'-phosphate phosphohydrolase
Reaction(IUBMB)
a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] + H2O = N7-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]
Reaction(KEGG)
(other) R04368
Show
Substrate
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] [CPD:C02339];
H2O [CPD:C00001]
Product
N7-methylguanosine 5'-phosphate;
5'-diphospho-[mRNA] [CPD:C02100]
Comment
The enzyme removes (decaps) the N7-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides [3,6]. Decapping is an important process in the control of eukaryotic mRNA degradation. The enzyme functions to clear the cell of cap structure following decay of the RNA body [2]. The nematode enzyme can also decap triply methylated substrates, 5'-(N2,N2,N7-trimethyl 5'-triphosphoguanosine)-[mRNA] [4].
History
EC 3.6.1.59 created 2012, modified 2013
Orthology
K12584  m7GpppX diphosphatase
Genes
HSA: 28960(DCPS)
PTR: 451655(DCPS)
PPS: 100974902(DCPS)
GGO: 101145375(DCPS)
PON: 100441593(DCPS)
NLE: 100601639(DCPS)
MCC: 717749(DCPS)
MCF: 102120410(DCPS)
CSAB: 103248789(DCPS)
RBB: 108542316(DCPS)
CJC: 100410129(DCPS)
SBQ: 101040093(DCPS)
MMU: 69305(Dcps)
RNO: 266605(Dcps)
CGE: 100761162(Dcps)
NGI: 103735398(Dcps)
HGL: 101715664(Dcps)
CCAN: 109698463(Dcps)
OCU: 100338456 108175353(DCPS)
TUP: 102484523(DCPS)
CFA: 609536(DCPS)
AML: 100470542(DCPS)
UMR: 103660653(DCPS)
ORO: 101375494(DCPS)
FCA: 101088950(DCPS)
PTG: 102969848(DCPS)
AJU: 106974920(DCPS)
BTA: 282640(DCPS)
BOM: 102278216(DCPS)
BIU: 109554166(DCPS)
PHD: 102317093(DCPS)
CHX: 102190586(DCPS)
OAS: 101114475(DCPS)
SSC: 396689(DCPS)
CFR: 102519944(DCPS)
CDK: 105094264(DCPS)
BACU: 103009141(DCPS)
LVE: 103078579(DCPS)
OOR: 101284952(DCPS)
ECB: 100064530(DCPS)
EPZ: 103549022(DCPS)
EAI: 106834017(DCPS)
MYB: 102251721(DCPS)
MYD: 102774242(DCPS)
HAI: 109391391(DCPS)
RSS: 109433905(DCPS)
PALE: 102879340(DCPS)
LAV: 100656614(DCPS)
TMU: 101343348
MDO: 100019554(DCPS)
SHR: 100935301(DCPS)
OAA: 100084391
GGA: 419716(DCPS)
MGP: 100544934(DCPS)
CJO: 107324199(DCPS)
APLA: 101792448(DCPS)
ACYG: 106040558(DCPS)
TGU: 100217679(DCPS)
GFR: 102035714(DCPS)
FAB: 101821090(DCPS)
PHI: 102102643(DCPS)
PMAJ: 107214434(DCPS)
CCAE: 111939373(DCPS)
CCW: 104692219(DCPS)
FPG: 101910550(DCPS)
FCH: 102047627(DCPS)
CLV: 106145844(DCPS)
EGZ: 104129234(DCPS)
AAM: 106498500(DCPS)
ASN: 102384846(DCPS)
AMJ: 102564856(DCPS)
PSS: 102454492(DCPS)
CMY: 102947472(DCPS)
CPIC: 101942376(DCPS)
ACS: 100567351(dcps)
PVT: 110088810(DCPS)
PBI: 103066095(DCPS)
GJA: 107119892(DCPS)
XLA: 394400(dcps.L)
XTR: 100216298(dcps)
NPR: 108794017(DCPS)
DRE: 402850(dcps)
SRX: 107758690
CCAR: 109098029(dcps)
IPU: 108276556(dcps)
AMEX: 103034238(dcps)
TRU: 445993(dcps)
LCO: 104932284(dcps)
NCC: 104948373(dcps)
MZE: 101484626(dcps)
OLA: 101158538(dcps)
XMA: 102224706(dcps)
PRET: 103471025(dcps)
NFU: 107382541(dcps)
KMR: 108240022(dcps)
LCF: 108878927(dcps)
SDU: 111226662(dcps)
HCQ: 109524308(dcps)
BPEC: 110172173(dcps)
MALB: 109957539(dcps)
SASA: 106603769(dcps)
OTW: 112228342(dcps)
ELS: 105028750(dcps)
SFM: 108921345(dcps)
LCM: 102361941(DCPS) 102366682
CMK: 103180338(dcps)
CIN: 100175982
SPU: 587255
APLC: 110983458
SKO: 100367637
DME: Dmel_CG2091(CG2091)
DER: 6552743
DPE: 6588316
DSI: Dsimw501_GD19585(Dsim_GD19585)
MDE: 101893363
AAG: 5571000
AME: 552284
BIM: 100746156
BTER: 100643261
SOC: 105202710
AEC: 105153426
ACEP: 105619523
PBAR: 105425029
HST: 105187533
DQU: 106746690
CFO: 105258276
LHU: 105678394
PGC: 109863073
PCF: 106787996
NVI: 100121865
MDL: 103577054
TCA: 658490
NVL: 108563755
BMOR: 101739862
PMAC: 106720528
PRAP: 111000036
HAW: 110381189
API: 100163679(Dcps)
DNX: 107168087
CLEC: 106665736
ZNE: 110833667
TUT: 107359431
CEL: CELE_Y113G7A.9(dcs-1)
CBR: CBG12933(Cbr-dcs-1)
TSP: Tsp_13171
CRG: 105342540
OBI: 106868479
LAK: 106179651
SHX: MS3_05736
EGL: EGR_00336
EPA: 110233505
ADF: 107337033
HMG: 100205537
AQU: 100632526
SCE: YLR270W(DCS1)
ERC: Ecym_3126
KMX: KLMA_40182(DCS1)
NCS: NCAS_0D02700(NCAS0D02700) NCAS_0F00320(NCAS0F00320)
NDI: NDAI_0I02210(NDAI0I02210) NDAI_0K02850(NDAI0K02850)
TPF: TPHA_0F02580(TPHA0F02580) TPHA_0K01170(TPHA0K01170)
TBL: TBLA_0A09660(TBLA0A09660) TBLA_0G00540(TBLA0G00540)
TDL: TDEL_0G04070(TDEL0G04070)
KAF: KAFR_0A05030(KAFR0A05030) KAFR_0G02510(KAFR0G02510)
CAL: CAALFM_C701190WA(CaO19.6901)
CAUR: QG37_01564
NCR: NCU06998
MGR: MGG_15696
SSCK: SPSK_00555
MAW: MAC_06415
MAJ: MAA_05059
ANI: AN7492.2
ANG: ANI_1_3306024(An02g13910)
ABE: ARB_03877
TVE: TRV_06634
PTE: PTT_17752
SPO: SPBP4H10.20(nhm1)
CNE: CNN00850
CNB: CNBN0860
ABP: AGABI1DRAFT114139(AGABI1DRAFT_114139)
ABV: AGABI2DRAFT193987(AGABI2DRAFT_193987)
MGL: MGL_3756
EHI: EHI_169590(223.t00003)
SPAR: SPRG_07731
 » show all
Taxonomy
Reference
1  [PMID:16963086]
  Authors
Malys N, McCarthy JE
  Title
Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies.
  Journal
J Mol Biol 363:370-82 (2006)
DOI:10.1016/j.jmb.2006.08.015
  Sequence
[sce:YLR270W]
Reference
2  [PMID:18441014]
  Authors
Liu SW, Rajagopal V, Patel SS, Kiledjian M
  Title
Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme.
  Journal
J Biol Chem 283:16427-36 (2008)
DOI:10.1074/jbc.M800341200
Reference
3  [PMID:12198172]
  Authors
Liu H, Rodgers ND, Jiao X, Kiledjian M
  Title
The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.
  Journal
EMBO J 21:4699-708 (2002)
  Sequence
[hsa:28960] [sce:YLR270W]
Reference
4  [PMID:14523240]
  Authors
van Dijk E, Le Hir H, Seraphin B
  Title
DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.
  Journal
Proc Natl Acad Sci U S A 100:12081-6 (2003)
DOI:10.1073/pnas.1635192100
  Sequence
[hsa:28960] [sce:YLR270W]
Reference
5  [PMID:15769464]
  Authors
Chen N, Walsh MA, Liu Y, Parker R, Song H
  Title
Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
  Journal
J Mol Biol 347:707-18 (2005)
DOI:10.1016/j.jmb.2005.01.062
  Sequence
[hsa:28960]
Reference
6  [PMID:15383679]
  Authors
Cohen LS, Mikhli C, Friedman C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE
  Title
Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and  characterization of C. elegans scavenger DcpS.
  Journal
RNA 10:1609-24 (2004)
DOI:10.1261/rna.7690504
  Sequence
Reference
7  [PMID:22985415]
  Authors
Wypijewska A, Bojarska E, Lukaszewicz M, Stepinski J, Jemielity J, Davis RE, Darzynkiewicz E
  Title
7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.
  Journal
Biochemistry 51:8003-13 (2012)
DOI:10.1021/bi300781g
  Sequence
[ag:ADB92583] [cel:CELE_Y113G7A.9] [hsa:28960] [sce:YLR270W]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.59
IUBMB Enzyme Nomenclature: 3.6.1.59
ExPASy - ENZYME nomenclature database: 3.6.1.59
BRENDA, the Enzyme Database: 3.6.1.59

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