Entry
Name
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;
DcpS;
m7GpppX pyrophosphatase;
m7GpppN m7GMP phosphohydrolase;
m7GpppX diphosphatase;
m7G5'ppp5'N m7GMP phosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] N7-methylguanosine 5'-phosphate phosphohydrolase
Reaction(IUBMB)
a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] + H2O = N7-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]
Reaction(KEGG)
Substrate
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] [CPD:
C02339 ];
H2O [CPD:
C00001 ]
Product
N7-methylguanosine 5'-phosphate;
5'-diphospho-[mRNA] [CPD:
C02100 ]
Comment
The enzyme removes (decaps) the N7-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides [3,6]. Decapping is an important process in the control of eukaryotic mRNA degradation. The enzyme functions to clear the cell of cap structure following decay of the RNA body [2]. The nematode enzyme can also decap triply methylated substrates, 5'-(N2,N2,N7-trimethyl 5'-triphosphoguanosine)-[mRNA] [4].
History
EC 3.6.1.59 created 2012, modified 2013
Orthology
Genes
PANU : 100997052(DCPS) 116268623
MPUF : 101671617(DCPS) 101692260
OAA : 100089721(DCPS) 114815064
SANH : 107653712 107671566
SGH : 107577914 107577915 107583391(dcps)
TRU : 115252309 445993(dcps)
SSEN : 122761366 122778794
ARUT : 117397254 117966544
LCM : 102361941(DCPS) 102366682
LPIC : 129256090 129256091 129258059
DSI : Dsimw501_GD19585(Dsim_GD19585)
AALB : 109413098 109418537 115257603
CGLO : 123269451 123274668 123274678
MSEX : 115452897 119188988
FCD : 110843464 110853186 110853187
PCLA : 123755412 123772615
HAZT : 108671885 108682239 108682718
PPOI : 119098349 119098569
PTEP : 107444564 107455807
ABRU : 129963413 129976609
UDV : 129216056 129227746 129232737
CEL : CELE_Y113G7A.9(dcs-1)
CBR : CBG_12933(Cbr-dcs-1)
BMY : BM_BM7299(Bma-dcs-1)
PMAX : 117319178 117331654
MPP : MICPUCDRAFT_38692(JGI:MicpuC2_38692)
VPO : Kpol_1035p6 Kpol_1042p10
NCS : NCAS_0D02700(NCAS0D02700) NCAS_0F00320(NCAS0F00320)
NDI : NDAI_0I02210(NDAI0I02210) NDAI_0K02850(NDAI0K02850)
TPF : TPHA_0F02580(TPHA0F02580) TPHA_0K01170(TPHA0K01170)
TBL : TBLA_0A09660(TBLA0A09660) TBLA_0G00540(TBLA0G00540)
TDL : TDEL_0G04070(TDEL0G04070)
KAF : KAFR_0A05030(KAFR0A05030) KAFR_0G02510(KAFR0G02510)
KNG : KNAG_0F02850(KNAG0F02850) KNAG_0M01030(KNAG0M01030)
CAL : CAALFM_C701190WA(CaO19.6901)
YLI : YALI0E08074g YALI0F31141g
CCAC : CcaHIS019_0510620(CcaverHIS019_0510620)
PPL : POSPLDRAFT_134967 POSPLDRAFT_93518
ABP : AGABI1DRAFT114139(AGABI1DRAFT_114139)
ABV : AGABI2DRAFT193987(AGABI2DRAFT_193987)
SCM : SCHCO_02636681(SCHCODRAFT_02636681)
EHI : EHI_169590(223.t00003)
EIV : EIN_154880 EIN_406030
PIF : PITG_00288 PITG_00291
PSOJ : PHYSODRAFT_316123 PHYSODRAFT_560555
GTT : GUITHDRAFT_137339 GUITHDRAFT_146688 GUITHDRAFT_74405 GUITHDRAFT_79107 GUITHDRAFT_80213
» show all
Taxonomy
Reference
Authors
Malys N, McCarthy JE
Title
Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies.
Journal
Sequence
Reference
Authors
Liu SW, Rajagopal V, Patel SS, Kiledjian M
Title
Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme.
Journal
Reference
Authors
Liu H, Rodgers ND, Jiao X, Kiledjian M
Title
The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.
Journal
Sequence
Reference
Authors
van Dijk E, Le Hir H, Seraphin B
Title
DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.
Journal
Sequence
Reference
Authors
Chen N, Walsh MA, Liu Y, Parker R, Song H
Title
Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.
Journal
Sequence
Reference
Authors
Cohen LS, Mikhli C, Friedman C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE
Title
Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS.
Journal
Sequence
Reference
Authors
Wypijewska A, Bojarska E, Lukaszewicz M, Stepinski J, Jemielity J, Davis RE, Darzynkiewicz E
Title
7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.59
ExPASy - ENZYME nomenclature database: 3.6.1.59