KEGG   ENZYME: 3.6.1.6Help
Entry
EC 3.6.1.6                  Enzyme                                 

Name
nucleoside diphosphate phosphatase;
nucleoside-diphosphatase;
thiaminpyrophosphatase;
UDPase;
inosine diphosphatase;
adenosine diphosphatase;
IDPase;
ADPase;
adenosinepyrophosphatase;
guanosine diphosphatase;
guanosine 5'-diphosphatase;
inosine 5'-diphosphatase;
uridine diphosphatase;
uridine 5'-diphosphatase;
type B nucleoside diphosphatase;
GDPase;
CDPase;
nucleoside 5'-diphosphatase;
type L nucleoside diphosphatase;
NDPase;
nucleoside diphosphate phosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
nucleoside-diphosphate phosphohydrolase
Reaction(IUBMB)
a nucleoside diphosphate + H2O = a nucleoside phosphate + phosphate [RN:R00329]
Reaction(KEGG)
Substrate
nucleoside diphosphate [CPD:C00454];
H2O [CPD:C00001]
Product
nucleoside phosphate [CPD:C01329];
phosphate [CPD:C00009]
Comment
The enzyme, which appears to be limited to metazoa, acts on multiple nucleoside diphosphates as well as on D-ribose 5-diphosphate. Specificity depends on species and isoform.
History
EC 3.6.1.6 created 1961
Pathway
ec00230  Purine metabolism
ec00240  Pyrimidine metabolism
Orthology
K01511  ectonucleoside triphosphate diphosphohydrolase 5/6
K12304  soluble calcium-activated nucleotidase 1
K12305  ectonucleoside triphosphate diphosphohydrolase 4
Genes
HSA: 124583(CANT1) 955(ENTPD6) 957(ENTPD5) 9583(ENTPD4)
PTR: 453027(ENTPD5) 458146(ENTPD6) 464056(ENTPD4) 468345(CANT1)
PPS: 100969324(ENTPD4) 100974659(CANT1) 100975707(ENTPD5) 100985458(ENTPD6)
GGO: 101126430(ENTPD6) 101142724(ENTPD5) 101148282(CANT1) 101148704(ENTPD4)
PON: 100433776(ENTPD4) 100449249(ENTPD6) 100454763(CANT1) 103892385(ENTPD5)
NLE: 100601352(CANT1) 100603393(ENTPD6) 100604246(ENTPD4) 100604959(ENTPD5)
MCC: 698503(ENTPD5) 705663(ENTPD6) 710935(CANT1) 717197(ENTPD4)
MCF: 102118635(ENTPD5) 102127579(CANT1) 102133506(ENTPD6) 102139183(ENTPD4)
CSAB: 103215479(ENTPD4) 103229320(ENTPD5) 103243671(CANT1) 103247059(ENTPD6)
RRO: 104657284(ENTPD4) 104659510 104661029(ENTPD6) 104677031(CANT1) 104677558(ENTPD5)
RBB: 108522410(ENTPD6) 108534172(CANT1) 108534899(ENTPD5) 108537903(ENTPD4)
CJC: 100394992(ENTPD5) 100395619(ENTPD4) 100402589(CANT1) 100412828(ENTPD6)
SBQ: 101035743(ENTPD5) 101044293(CANT1) 101048728(ENTPD6) 101049938(ENTPD4)
MMU: 100862375(Entpd4b) 12497(Entpd6) 12499(Entpd5) 67464(Entpd4) 76025(Cant1)
RNO: 246272(Cant1) 314312(Entpd5) 361063(Entpd4) 85260(Entpd6)
CGE: 100751454(Entpd5) 100765414(Entpd6) 100767250(Cant1) 100771637(Entpd4)
NGI: 103747295(Cant1) 103747371(Entpd5) 103748013(Entpd4) 103748530(Entpd6)
HGL: 101700645(Entpd4) 101703881(Entpd5) 101708374(Cant1) 101717001(Entpd6)
CCAN: 109682707(Cant1) 109688404(Entpd5) 109689699 109689706 109699832(Entpd6)
OCU: 100341814(ENTPD5) 100342665(ENTPD6) 100345399(ENTPD4) 100352568(CANT1) 108176291
TUP: 102473435(ENTPD5) 102477259(ENTPD6) 102482611(CANT1) 102499936(ENTPD4)
CFA: 480384(ENTPD5) 485564(ENTPD6) 486117(ENTPD4)
AML: 100470325(ENTPD5) 100474095 100475785(ENTPD4) 109488325(CANT1)
UMR: 103671253(ENTPD5) 103681915(ENTPD6)
ORO: 101363791(ENTPD6) 101363814(ENTPD4) 101374973(ENTPD5)
FCA: 101085117(ENTPD4) 101090270(ENTPD5) 101090852(ENTPD6)
PTG: 102952970(ENTPD4) 102958703(ENTPD5) 102966424(ENTPD6) 102968784(CANT1)
AJU: 106974434(ENTPD5) 106980293(ENTPD6) 106981113(ENTPD4) 106981887(CANT1)
BTA: 508097(ENTPD6) 518086(CANT1) 531411(ENTPD4) 533096(ENTPD5)
BOM: 102264690(ENTPD6) 102272160(CANT1) 102277970 102278224(ENTPD5) 102283172(ENTPD4) 106701632
BIU: 109563130(ENTPD4) 109565341(ENTPD5) 109568065(ENTPD6) 109574131(CANT1)
PHD: 102316077(ENTPD6) 102317546(CANT1) 102321161(ENTPD4) 102323649(ENTPD5)
CHX: 102174488(ENTPD6) 102177094(CANT1) 102177626(ENTPD4) 102187956(ENTPD5)
OAS: 101104845(ENTPD6) 101105824(ENTPD5) 101120555(ENTPD4) 101122609(CANT1)
SSC: 100154506(ENTPD5) 100155254(ENTPD4) 100620107(CANT1) 100626131(ENTPD6)
CFR: 102506563(ENTPD4) 102507072 102513093(ENTPD6) 102521166(CANT1) 102524265(ENTPD5)
CDK: 105086117(ENTPD5) 105099848(ENTPD6) 105102460(ENTPD4) 105105800(CANT1)
BACU: 103001237(ENTPD4) 103008563(ENTPD5) 103016453(CANT1) 103017331(ENTPD6)
LVE: 103069753(CANT1) 103072735(ENTPD6) 103076010(ENTPD5) 103090675(ENTPD4)
OOR: 101274835(ENTPD4) 101279340(ENTPD5) 101285084(ENTPD6) 101286631(CANT1)
ECB: 100053982(ENTPD4) 100056466(ENTPD5) 100057043(ENTPD6) 100057405(CANT1)
EPZ: 103544225(ENTPD6) 103550751(ENTPD4) 103551442(CANT1) 103560626(ENTPD5)
EAI: 106827399(ENTPD6) 106827629(ENTPD4) 106827678(ENTPD5) 106845398(CANT1)
MYB: 102243929(ENTPD6) 102251396(CANT1) 102251399(ENTPD4) 102262670(ENTPD5)
MYD: 102756459(ENTPD5) 102761731(ENTPD6) 102767239(ENTPD4) 102768384(CANT1)
HAI: 109372329(ENTPD4) 109378612(ENTPD6) 109381563(ENTPD5) 109383715(CANT1)
RSS: 109436279(ENTPD4) 109448271(ENTPD5) 109449392(CANT1)
PALE: 102879280(ENTPD6) 102879747(ENTPD4) 102885970(ENTPD5) 102886824(CANT1)
LAV: 100662574(ENTPD4) 100670458(CANT1) 100670899(ENTPD6) 100671455(ENTPD5)
MDO: 100021277(ENTPD4) 100024118(ENTPD5) 100026552(CANT1) 100033226(ENTPD6)
SHR: 100914260(ENTPD4) 100925749 100934101(CANT1) 100934821(ENTPD5) 100935093(ENTPD6)
OAA: 100075558(ENTPD4) 100088014(CANT1) 100088379(ENTPD6)
GGA: 416708(ENTPD6) 419531(ENTPD4) 423343(ENTPD5) 430103(CANT1)
MGP: 100539042(ENTPD5) 100541241(ENTPD6) 100546671(CANT1) 100550411(ENTPD4)
CJO: 107310965(ENTPD6) 107315087(ENTPD5) 107322204(CANT1) 107323626(ENTPD4)
APLA: 101790396(CANT1) 101794207(ENTPD5) 101795352(ENTPD4) 101798772(ENTPD6)
ACYG: 106038827(ENTPD5) 106044765(ENTPD6) 106046784(CANT1) 106049706(ENTPD4)
TGU: 100219260(CANT1) 100220000(ENTPD5) 100224923(ENTPD6)
GFR: 102033650(ENTPD5) 102035287(ENTPD6) 102035478(CANT1) 102044536(ENTPD4)
FAB: 101811604(CANT1) 101814014(ENTPD6) 101814697(ENTPD4) 101820141(ENTPD5)
PHI: 102101855(ENTPD4) 102106545(ENTPD5) 102108288(CANT1) 102109632(ENTPD6)
PMAJ: 107202034(ENTPD6) 107205897(ENTPD5) 107212434(CANT1) 107213958(ENTPD4)
CCAE: 111937476(CANT1) 111938755(ENTPD4) 111942216(ENTPD6) 111945531(ENTPD5)
CCW: 104685058(ENTPD5) 104694876(ENTPD4) 104696652(ENTPD6) 104698209(CANT1)
FPG: 101910519(ENTPD4) 101911075(ENTPD5) 101912651(CANT1) 101920667(ENTPD6)
FCH: 102047237(ENTPD6) 102056974(ENTPD5) 102057968(CANT1) 102058083(ENTPD4)
CLV: 102084705(ENTPD5) 102084729(CANT1) 102092438(ENTPD4) 102095170(ENTPD6)
EGZ: 104123518(ENTPD4) 104128771(ENTPD6) 104133292(ENTPD5) 104133521(CANT1)
AAM: 106482860(ENTPD5) 106485706(ENTPD4) 106487146(CANT1) 106494176(ENTPD6)
ASN: 102377226(ENTPD5) 102382407(ENTPD4) 102384786(ENTPD6) 102387737(CANT1)
AMJ: 102558177(ENTPD5) 102558389(ENTPD4) 102558883(CANT1) 102561141(ENTPD6)
PSS: 102446197(ENTPD5) 102448778(ENTPD6) 102457836(ENTPD4) 102457946(CANT1)
CMY: 102933100(ENTPD6) 102944019(ENTPD4) 102944229(ENTPD5) 102947400(CANT1)
CPIC: 101936718(CANT1) 101938561(ENTPD6) 101947170(ENTPD4) 101951614(ENTPD5)
ACS: 100555642(entpd5) 100561218(entpd6) 100562980(entpd4) 100563392(cant1) 103282882
PVT: 110072190(ENTPD4) 110079567(ENTPD6) 110086369(ENTPD5) 110090286(CANT1)
PBI: 103048410(ENTPD6) 103051878(CANT1) 103054355(ENTPD5) 103056945(ENTPD4)
GJA: 107107286(ENTPD4) 107111965(ENTPD6) 107115314(CANT1) 107123169(ENTPD5)
XLA: 108712719(entpd4.S) 379060(cant1.L) 495422(entpd4.L) 734187(entpd6.L) 734189(entpd5.L)
XTR: 394537(cant1) 677731(entpd4) 677734(entpd5) 677735(entpd6)
NPR: 108792480(ENTPD4) 108796391(CANT1) 108801077(ENTPD6) 108802467(ENTPD5)
DRE: 406558(cant1a) 436692(entpd4) 445201(cant1b) 550560(entpd6) 556849(entpd5a)
IPU: 108257529(ENTPD5) 108265395(entpd4) 108269455(entpd5) 108270072(entpd6) 108270889(cant1)
AMEX: 103031064(entpd6) 103034776 103035312 103035579(entpd4) 103043327(entpd5)
TRU: 101061741 101063748 101065382(entpd6) 101070342(entpd5) 101075790(entpd4) 101076188(cant1)
LCO: 104919812 104921415(entpd5) 104922273 104925070(cant1) 104934622(entpd4) 104936920(entpd6) 109142576
OLA: 101158069 101165115(entpd5) 101171168(cant1) 101172088(entpd4) 101172636 101173329(entpd6)
XMA: 102222595(entpd5) 102222865(cant1) 102222913(entpd6) 102226763 102226786 102236347(entpd4)
PRET: 103457894 103459024(entpd5) 103465407 103468847(cant1) 103470498(entpd4) 103477400(entpd6)
KMR: 108229509 108231867 108232039(entpd5) 108236422 108236441(entpd4) 108241365(cant1) 108250727(entpd6)
CSEM: 103381017 103387028(entpd6) 103392811(cant1) 103397390(entpd5) 103398226(entpd4)
LCF: 108873841(entpd6) 108878709(entpd4) 108891815 108892557(entpd5) 108896911 108902724(cant1)
HCQ: 109513178(entpd5) 109517726(cant1) 109525218 109527423
MALB: 109955156(entpd5) 109957004(entpd4) 109957848 109962192 109972252(cant1) 109972990(entpd6)
ELS: 105012018 105013048(cant1) 105014029(entpd4) 105017536 105025521(entpd6) 105026440(entpd5)
LCM: 102345277(CANT1) 102354256(ENTPD6) 102364599(ENTPD4) 102364924(ENTPD5)
CMK: 103175547(cant1) 103179204(entpd6) 103186794(entpd5) 103188915(entpd7) 103191300
SPU: 576801 580175(entpd4) 587808
DME: Dmel_CG3059(NTPase) Dmel_CG5276(CG5276)
DSI: Dsimw501_GD18755(Dsim_GD18755) Dsimw501_GD22791(Dsim_GD22791)
TUT: 107367568
CEL: CELE_F08C6.6(apy-1) CELE_K08H10.4(uda-1) CELE_R07E4.4(mig-23) CELE_ZK563.7(ZK563.7)
CBR: CBG11542(Cbr-uda-1) CBG14198 CBG14784(Cbr-mig-23) CBG16731
BMY: Bm1_34420
EGL: EGR_01099
EHI: EHI_053610(59.t00033) EHI_104590(415.t00008) EHI_112890(17.t00006)
CPV: cgd6_1570
SMIN: v1.2.014804.t1(symbB.v1.2.014804.t1) v1.2.033374.t1(symbB.v1.2.033374.t1)
PSTT: CH92_09400
 » show all
Taxonomy
Reference
1  [PMID:14389272]
  Authors
GIBSON DM, AYENGAR P, SANADI DR.
  Title
A phosphatase specific for nucleoside diphosphates.
  Journal
Biochim Biophys Acta 16:536-8 (1955)
DOI:10.1016/0006-3002(55)90275-4
Reference
2
  Authors
Horecker, B.L., Hurwitz, J. and Heppel, L.A.
  Title
The synthesis of ribose 5-pyrophosphate and ribose 5-triphosphate.
  Journal
J Am Chem Soc 79:701-702 (1957)
Reference
3  [PMID:11041856]
  Authors
Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE
  Title
CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart.
  Journal
Biochemistry 39:12916-23 (2000)
DOI:10.1021/bi000959z
  Sequence
[hsa:955]
Reference
4  [PMID:12167635]
  Authors
Failer BU, Braun N, Zimmermann H
  Title
Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase.
  Journal
J Biol Chem 277:36978-86 (2002)
DOI:10.1074/jbc.M201656200
  Sequence
[hsa:124583] [rno:246272]
Reference
5  [PMID:15102851]
  Authors
Uccelletti D, O'Callaghan C, Berninsone P, Zemtseva I, Abeijon C, Hirschberg CB
  Title
ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase  from Caenorhabditis elegans.
  Journal
J Biol Chem 279:27390-8 (2004)
DOI:10.1074/jbc.M402624200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.6
IUBMB Enzyme Nomenclature: 3.6.1.6
ExPASy - ENZYME nomenclature database: 3.6.1.6
BRENDA, the Enzyme Database: 3.6.1.6
CAS: 9027-69-4

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