KEGG   ENZYME: 3.6.1.62Help
Entry
EC 3.6.1.62                 Enzyme                                 

Name
5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase;
Dcp2;
NUDT16;
D10 protein;
D9 protein;
D10 decapping enzyme;
decapping enzyme;
m7GpppN-mRNA hydrolase;
m7GpppN-mRNA m7GDP phosphohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
5'-(N7-methylguanosine 5'-triphospho)-[mRNA] N7-methylguanosine-5'-diphosphate phosphohydrolase
Reaction(IUBMB)
a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] + H2O = N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA] [RN:R10815]
Reaction(KEGG)
Substrate
5'-(N7-methylguanosine 5'-triphospho)-[mRNA] [CPD:C02339];
H2O [CPD:C00001]
Product
N7-methylguanosine 5'-diphosphate [CPD:C20183];
5'-phospho-[mRNA] [CPD:C20863]
Comment
Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) [3]. The enzyme from Vaccinia virus is synergistically activated in the presence of Mg2+ and Mn2+ [5].
History
EC 3.6.1.62 created 2012, modified 2013
Orthology
K12613  mRNA-decapping enzyme subunit 2
K16855  U8 snoRNA-decapping enzyme
Genes
HSA: 131870(NUDT16) 167227(DCP2)
PTR: 107966544(NUDT16) 460696(NUDT16P1) 462001(DCP2)
PPS: 100972453(NUDT16) 100991689(DCP2)
GGO: 101141130(DCP2) 101147310 109026149(NUDT16)
PON: 100127054(DCP2) 100433503 100434247
NLE: 100588130(DCP2) 100607601(NUDT16)
MCC: 694225(DCP2) 717914(NUDT16) 717946
MCF: 101865654(NUDT16) 102131910(DCP2) 102141246
CSAB: 103241683 103244344(DCP2)
RRO: 104672110(DCP2) 104675668(NUDT16)
RBB: 108512901(DCP2) 108522243(NUDT16)
CJC: 100406671 100410770(NUDT16) 100415186(DCP2)
SBQ: 101047930(DCP2) 101048719(NUDT16) 101049032
MMU: 70640(Dcp2) 73532(1700080E11Rik) 75686(Nudt16)
RNO: 291604(Dcp2) 363129(Nudt16) 688828
CGE: 100768978(Nudt16) 100769259 100773631(Dcp2)
CCAN: 109687908(Dcp2) 109700639(Nudt16)
TUP: 102479774(NUDT16) 102485280(DCP2)
CFA: 489086(DCP2) 610721(NUDT16)
AML: 100473528(DCP2) 100482941(NUDT16)
UMR: 103675800(DCP2)
ORO: 101364270(NUDT16) 101373544(DCP2)
FCA: 101094947(NUDT16) 101097375(DCP2)
PTG: 102951403(NUDT16) 102972191(DCP2)
AJU: 106971584(NUDT16) 106973160(DCP2)
BTA: 512320(NUDT16) 539770(DCP2)
BOM: 102264435(NUDT16) 102273448(DCP2)
BIU: 109564602(DCP2)
PHD: 102318311(NUDT16) 102345026(DCP2)
CHX: 102175719(NUDT16) 102183421(DCP2)
OAS: 101103649(DCP2) 654329(NUDT16)
SSC: 100152693(NUDT16) 100516785(DCP2)
CFR: 102519457 102523799(DCP2)
CDK: 105088763(NUDT16) 105095384(DCP2)
BACU: 102999966(DCP2) 103000667(NUDT16)
LVE: 103082110(DCP2) 103090159(NUDT16)
OOR: 101274817(DCP2) 101280616(NUDT16)
ECB: 100064676(NUDT16) 100073182(DCP2)
EPZ: 103552688(NUDT16) 103558655(DCP2)
EAI: 106832215(DCP2) 106841819(NUDT16)
MYB: 102252289(NUDT16) 102255386(DCP2)
MYD: 102769718(NUDT16) 102775483(DCP2)
HAI: 109378247(NUDT16) 109391523(DCP2)
RSS: 109444504(NUDT16) 109445421(DCP2)
PALE: 102881202(DCP2) 102891676(NUDT16)
LAV: 100666216(NUDT16) 100672769(DCP2)
MDO: 100015769(DCP2) 100029401(NUDT16)
SHR: 100921288(NUDT16) 100922624(DCP2)
OAA: 100075661(DCP2)
GGA: 769972(DCP2)
MGP: 104915159(DCP2) 104916418
CJO: 107306346(DCP2) 107307442
APLA: 101801466(DCP2)
ACYG: 106046535(DCP2)
TGU: 100190266(NUDT16L1) 100223050(DCP2)
GFR: 102040916(DCP2)
FAB: 101818690(DCP2)
PHI: 102099718(DCP2)
PMAJ: 107216210(DCP2)
CCW: 104684172(DCP2)
FPG: 101913793(DCP2)
FCH: 102051202(DCP2)
CLV: 102093391(DCP2)
EGZ: 104135070(DCP2)
AAM: 106494088(DCP2)
ASN: 102373084 102379438(DCP2)
AMJ: 102567941(DCP2) 109283987
PSS: 102463280(DCP2)
CMY: 102946837(DCP2)
CPIC: 101939820(NUDT16) 101950053(DCP2)
ACS: 100561966(dcp2) 100563390(nudt16)
PVT: 110072037(DCP2) 110078648
PBI: 103061512(DCP2) 103066411(NUDT16)
GJA: 107108063 107116680(DCP2)
XLA: 108707213(dcp2.S) 414677(nudt16.L) 606489(dcp2.L)
XTR: 100327255(nudt16) 549617(dcp2)
NPR: 108784477 108791887(DCP2)
DRE: 393121(dcp2) 449987(zgc:103759)
IPU: 108276081 108276714(dcp2)
AMEX: 103041050 103047414(dcp2)
TRU: 101067770(dcp2) 101075218
LCO: 104930759 104935941(dcp2)
MZE: 101466673(nudt16) 101475888(dcp2)
XMA: 102222647(dcp2) 102224429
PRET: 103466890 103473121(dcp2)
NFU: 107391353 107394956(dcp2)
CSEM: 103384574 103389093(dcp2)
LCF: 108877699(dcp2) 108882689
BPEC: 110158096 110161635(dcp2)
SASA: 100195938(dcp2) 106581882
ELS: 105018732 105021715(dcp2)
SFM: 108918382 108929971(dcp2)
LCM: 102355675(DCP2) 102358340
CMK: 103181144(dcp2) 103191283
SPU: 581337
APLC: 110988689
SKO: 100366293
DME: Dmel_CG6169(DCP2)
DSI: Dsimw501_GD12535(Dsim_GD12535)
MDE: 101892350
AAG: 5579298
AME: 412521
BIM: 100743675
SOC: 105203061
AEC: 105154733
ACEP: 105626728
PBAR: 105430070
HST: 105185063
CFO: 105251021
LHU: 105671104
PGC: 109860579
NVI: 100123522
TCA: 656834
DPA: 109544974
NVL: 108563721
BMOR: 101737812(Dcp2)
PMAC: 106714651
PRAP: 111003278
CEL: CELE_F52G2.1(dcap-2)
CBR: CBG01756(Cbr-dcap-2)
BMY: Bm1_26285
TSP: Tsp_04018
EGL: EGR_07349
ATH: AT5G13570(DCP2)
CRB: 17881610
CPAP: 110814554
CIT: 102622483
TCC: 18586396
GRA: 105776314
GHI: 107915844
DZI: 111310309
EGR: 104421790
VRA: 106774768
VAR: 108321497
CCAJ: 109812349
CAM: 101506944
LJA: Lj0g3v0300239.1(Lj0g3v0300239.1)
ADU: 107491551
AIP: 107645027
FVE: 101292652
PPER: 18786723
PMUM: 103332371
PAVI: 110767993
ZJU: 107421455
RCU: 8279057
JCU: 105650903
HBR: 110636808
VVI: 100249543
SLY: 101252182
SPEN: 107018547
SOT: 102585242
CANN: 107871481
NSY: 104221029
NTO: 104094254
INI: 109188070
OEU: 111377886
HAN: 110913043
LSV: 111915063
DCR: 108219670
BVG: 104906355
SOE: 110801954
NNU: 104602620
OSA: 4331069
DOSA: Os02t0805900-01(Os02g0805900)
OBR: 107303562
BDI: 104583839
ATS: 109737407(LOC109737407)
SBI: 8065107
SITA: 101774232
EGU: 105053485
MUS: 104000383
DCT: 110101724
ATR: 18995774
CRE: CHLREDRAFT_146010(DCP2)
MNG: MNEG_6174
APRO: F751_4874
SCE: YNL118C(DCP2)
ERC: Ecym_8207
KMX: KLMA_60245(DCP2)
NCS: NCAS_0G02500(NCAS0G02500)
NDI: NDAI_0F02790(NDAI0F02790)
TPF: TPHA_0I01530(TPHA0I01530)
TBL: TBLA_0C05550(TBLA0C05550)
TDL: TDEL_0B05170(TDEL0B05170)
KAF: KAFR_0J02070(KAFR0J02070)
CAL: CAALFM_CR08120CA(DCP2)
CAUR: QG37_07750
SLB: AWJ20_3177(DCP2)
NCR: NCU07889
NTE: NEUTE1DRAFT146058(NEUTE1DRAFT_146058)
MGR: MGG_06410
SSCK: SPSK_02173
MAW: MAC_08320
MAJ: MAA_03604
CMT: CCM_06723
MBE: MBM_01128
ANI: AN0060.2
ANG: ANI_1_1634124(An14g06800)
PBL: PAAG_11508(PAAG_02506)
PBN: PADG_11955(PADG_05651)
ABE: ARB_03404
TVE: TRV_08090
PTE: PTT_19311
SPO: SPAC19A8.12(dcp2)
CNE: CNK00240
CNB: CNBK3180
ABP: AGABI1DRAFT66937(AGABI1DRAFT_66937)
ABV: AGABI2DRAFT214247(AGABI2DRAFT_214247)
MGL: MGL_1038
DDI: DDB_G0283315(dcp2)
DFA: DFA_08149 DFA_09800(dcp2)
EHI: EHI_058810(230.t00023) EHI_098250(77.t00025)
PYO: PY17X_1409100(PY07320)
PCB: PCHAS_140930(PC302629.00.0)
TAN: TA02540
TPV: TP03_0049
BBO: BBOV_III003580(17.m07337)
CPV: cgd7_2710
SMIN: v1.2.021593.t1(symbB.v1.2.021593.t1)
SPAR: SPRG_09982
SULR: B649_03915
 » show all
Taxonomy
Reference
1  [PMID:17158604]
  Authors
Xu J, Yang JY, Niu QW, Chua NH
  Title
Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development.
  Journal
Plant Cell 18:3386-98 (2006)
DOI:10.1105/tpc.106.047605
  Sequence
[ath:AT5G13570]
Reference
2  [PMID:21337011]
  Authors
Lu G, Zhang J, Li Y, Li Z, Zhang N, Xu X, Wang T, Guan Z, Gao GF, Yan J
  Title
hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA.
  Journal
Protein Cell 2:64-73 (2011)
DOI:10.1007/s13238-011-1009-2
  Sequence
[hsa:131870]
Reference
3  [PMID:12486012]
  Authors
van Dijk E, Cougot N, Meyer S, Babajko S, Wahle E, Seraphin B
  Title
Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures.
  Journal
EMBO J 21:6915-24 (2002)
Reference
4  [PMID:17283339]
  Authors
Parrish S, Resch W, Moss B
  Title
Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression.
  Journal
Proc Natl Acad Sci U S A 104:2139-44 (2007)
DOI:10.1073/pnas.0611685104
Reference
5  [PMID:19210265]
  Authors
Souliere MF, Perreault JP, Bisaillon M
  Title
Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism.
  Journal
Biochem J 420:27-35 (2009)
DOI:10.1042/BJ20082296
Reference
6  [PMID:17881455]
  Authors
Parrish S, Moss B
  Title
Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxviruses.
  Journal
J Virol 81:12973-8 (2007)
DOI:10.1128/JVI.01668-07
Reference
7  [PMID:21070968]
  Authors
Song MG, Li Y, Kiledjian M
  Title
Multiple mRNA decapping enzymes in mammalian cells.
  Journal
Mol Cell 40:423-32 (2010)
DOI:10.1016/j.molcel.2010.10.010
  Sequence
[hsa:167227 131870] [mmu:70640 75686]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.62
IUBMB Enzyme Nomenclature: 3.6.1.62
ExPASy - ENZYME nomenclature database: 3.6.1.62
BRENDA, the Enzyme Database: 3.6.1.62

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