KEGG   ENZYME: 3.6.3.9Help
Entry
EC 3.6.3.9                  Enzyme                                 

Name
Na+/K+-exchanging ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (Na+/K+-exchanging)
Reaction(IUBMB)
ATP + H2O + Na+in + K+out = ADP + phosphate + Na+out + K+in
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+ [CPD:C01330];
K+ [CPD:C00238]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+ [CPD:C01330];
K+ [CPD:C00238]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.
History
EC 3.6.3.9 created 1984 as EC 3.6.1.37, transferred 2000 to EC 3.6.3.9, modified 2001
Orthology
K01539  sodium/potassium-transporting ATPase subunit alpha
Genes
HSA: 476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 480(ATP1A4)
PTR: 456068(ATP1A3) 457152(ATP1A1) 457432(ATP1A2) 458010(ATP1A4)
PPS: 100968564(ATP1A2) 100968910(ATP1A4) 100973141(ATP1A3) 100992562(ATP1A1)
GGO: 101132606(ATP1A2) 101133472(ATP1A4) 101136136(ATP1A3) 101154367(ATP1A1)
PON: 100172203(ATP1A2) 100174388(ATP1A1) 100440055(ATP1A3) 100451523(ATP1A4)
NLE: 100585801(ATP1A2) 100586342(ATP1A4) 100596870(ATP1A1) 100604238(ATP1A3)
MCC: 706513(ATP1A3) 710368(ATP1A1) 719623(ATP1A4) 720191(ATP1A2)
MCF: 102122869(ATP1A3) 102124503(ATP1A1) 102144576(ATP1A4) 102145563(ATP1A2)
CSAB: 103223730(ATP1A4) 103223733(ATP1A2) 103224143(ATP1A1) 103234751(ATP1A3)
RRO: 104658863(ATP1A3) 104660405(ATP1A4) 104660406(ATP1A2) 104665933(ATP1A1)
RBB: 108524039(ATP1A4) 108524041(ATP1A2) 108528132(ATP1A1)
CJC: 100393318(ATP1A1) 100402438(ATP1A2) 100403160(ATP1A4) 100410682(ATP1A3)
SBQ: 101035314 101035941(ATP1A2) 101041249(ATP1A1) 101044048(ATP1A3) 104652875
MMU: 11928(Atp1a1) 232975(Atp1a3) 27222(Atp1a4) 98660(Atp1a2)
RNO: 24211(Atp1a1) 24212(Atp1a2) 24213(Atp1a3) 29132(Atp1a4)
CGE: 100758209(Atp1a3) 100763191(Atp1a4) 100763478(Atp1a2) 100771378(Atp1a1)
NGI: 103734951(Atp1a1) 103740231(Atp1a2) 103740266(Atp1a4) 103744609(Atp1a3)
HGL: 101697634(Atp1a1) 101721060(Atp1a4) 101721146(Atp1a3) 101721770(Atp1a2)
CCAN: 109681948 109688512(Atp1a3) 109690073(Atp1a4) 109690076
OCU: 100008756(ATP1A2) 100302415(ATP1A1) 100349382(ATP1A3) 100358269(ATP1A4) 103346768
TUP: 102475448(ATP1A3) 102483255(ATP1A2) 102483989 102483994(ATP1A1)
CFA: 403992(ATP1A1) 488636 612463(ATP1A3)
AML: 100477585(ATP1A3) 100477989(ATP1A1) 100480641(ATP1A2) 100480890(ATP1A4)
UMR: 103669413(ATP1A1) 103672049(ATP1A4) 103672113(ATP1A2) 103680185(ATP1A3)
ORO: 101366083(ATP1A1) 101376936(ATP1A3) 101379349(ATP1A2) 101379646(ATP1A4)
FCA: 101083636(ATP1A3) 101083695(ATP1A1) 101096375(ATP1A4) 101096785
PTG: 102954810 102955336(ATP1A3) 102955398 102957431(ATP1A4) 102971148(ATP1A1)
AJU: 106969643(ATP1A1) 106978517(ATP1A4) 106985576(ATP1A2) 106987698(ATP1A3)
BTA: 282144(ATP1A1) 282598(ATP1A3) 515161(ATP1A2) 537960(ATP1A4)
BOM: 102270922(ATP1A3) 102271837(ATP1A2) 102272122(ATP1A4) 102287260(ATP1A1)
BIU: 109555876(ATP1A1) 109571737(ATP1A3) 109578704(ATP1A4) 109578722
PHD: 102341310(ATP1A1) 102343479(ATP1A2) 102343841(ATP1A4) 102344375(ATP1A3)
CHX: 102179588(ATP1A3) 102183561(ATP1A1) 102186069(ATP1A4) 102186539(ATP1A2)
OAS: 101103751(ATP1A3) 101118148(ATP1A2) 101118398 443381(ATP1A1)
SSC: 100157711 100329126(ATP1A3) 396828(ATP1A2) 397481(ATP1A1)
CFR: 102509736(ATP1A1) 102516053(ATP1A2) 102516646(ATP1A4) 102517975(ATP1A3)
CDK: 105089616(ATP1A1) 105090227(ATP1A3) 105100141(ATP1A2)
BACU: 102998568(ATP1A1) 103005321(ATP1A4) 103005600(ATP1A2) 103011003(ATP1A3)
LVE: 103068908(ATP1A3) 103074614(ATP1A4) 103074894(ATP1A2) 103085693(ATP1A1)
OOR: 101279507(ATP1A1) 101280223(ATP1A3) 101288540(ATP1A4) 101288792(ATP1A2)
ECB: 100034139(ATP1A1) 100058251(ATP1A2) 100058301(ATP1A4) 100069796(ATP1A3)
EAI: 106835689(ATP1A1) 106835754(ATP1A4) 106835755(ATP1A2) 106847933(ATP1A3)
MYB: 102242637(ATP1A3) 102243691(ATP1A1) 102243972(ATP1A4) 102244267(ATP1A2) 102260737
MYD: 102757270(ATP1A2) 102757556(ATP1A4) 102762810(ATP1A3) 102770472(ATP1A1)
HAI: 109374442 109374464(ATP1A3) 109386454 109386501(ATP1A2) 109392813(ATP1A1)
RSS: 109435707(ATP1A3) 109437283(ATP1A2) 109446683(ATP1A1)
PALE: 102884868(ATP1A4) 102885125 102888359(ATP1A1) 102893697(ATP1A3)
LAV: 100661428(ATP1A1) 100667801 100668326(ATP1A3) 100674070(ATP1A2)
MDO: 100029759(ATP1A2)
SHR: 100914130 100918637 100922123(ATP1A3) 100928210(ATP1A1)
GGA: 396530(ATP1A1)
MGP: 100303690(ATP1A1) 104915899
APLA: 101797095 101801864(ATP1A1)
ACYG: 106029333 106037472(ATP1A1)
TGU: 100190719(ATP1A1)
GFR: 102036467(ATP1A1) 102044935
PHI: 102099305 102104980 102106372(ATP1A1) 102107817(ATP1A2)
PMAJ: 107207264(ATP1A1)
CCW: 104687046(ATP1A1)
FPG: 101914787(ATP1A1) 101915017(ATP1A2)
FCH: 102050259(ATP1A1) 102059303(ATP1A2)
CLV: 102092496(ATP1A1) 102093141
EGZ: 104126505(ATP1A1)
AAM: 106490649(ATP1A1) 106500059(ATP1A2)
AMJ: 102567591(ATP1A1) 102575084(ATP1A2) 106737151
CMY: 102936217(ATP1A1) 102938341(ATP1A2) 102943620
CPIC: 101931556(ATP1A3) 101933418(ATP1A1) 101934511 101950302(ATP1A2)
XLA: 108697760 108699431 380132(atp1a3.L) 398583(atp1a1.S) 398752(atp1a2.S) 399285(atp1a1.L)
XTR: 100125050(atp1a2) 100145440(atp1a3) 395044(atp1a1)
DRE: 64609(atp1a2a) 64610(atp1a3a) 64611(atp1a3b) 64612(atp1a1a.1) 64616(atp1a1b)
LCM: 102346835 102352604(ATP1A2) 102353554(ATP1A1) 102356851(ATP1A3)
SPU: 404637
APLC: 110976714
SKO: 100370816(ATP1A1)
DME: Dmel_CG45062(CG45062) Dmel_CG45760 Dmel_CG5670(Atpalpha)
DSI: Dsimw501_GD19388(Dsim_GD19388) Dsimw501_GD19691(Dsim_GD19691) Dsimw501_GD29095(Dsim_GD29095)
MDE: 101893028
AAG: 5575790
CLEC: 106667156
CEL: CELE_B0365.3(eat-6) CELE_C01G12.8(catp-4) CELE_C02E7.1(catp-2) CELE_Y105E8A.12(catp-1)
CBR: CBG01656 CBG09434(Cbr-eat-6)
BMY: Bm1_51740
CRG: 105338008
MYI: 110459295
OBI: 106880261
EGL: EGR_08003
PIC: PICST_60178(PMR2)
CAL: CAALFM_CR01630CA(CaO19.2552) CAALFM_CR01640CA(CaO19.2553)
CAUR: QG37_03453
SLB: AWJ20_4150(PMR1)
MBE: MBM_04409
ANI: AN8941.2
ANG: ANI_1_1014084(An09g00930) ANI_1_352124(An14g02290)
PTE: PTT_00480
SMIN: v1.2.000245.t1(symbB.v1.2.000245.t1) v1.2.028598.t1(symbB.v1.2.028598.t1)
TCX: Tcr_1065
CYQ: Q91_1618
DAR: Daro_1851
GUR: Gura_3300
GEO: Geob_1849
PCA: Pcar_2279
SAT: SYN_02485
MAC: MA_4378
MBAR: MSBR2_3266
MBAK: MSBR3_3261
MMA: MM_1069
MMAC: MSMAC_0238
METM: MSMTP_0268
MHOR: MSHOH_0294
MBU: Mbur_0431
MPY: Mpsy_0778
 » show all
Taxonomy
Reference
1  [PMID:13412736]
  Authors
SKOU JC.
  Title
The influence of some cations on an adenosine triphosphatase from peripheral nerves.
  Journal
Biochim Biophys Acta 23:394-401 (1957)
DOI:10.1016/0006-3002(57)90343-8
Reference
2  [PMID:14284759]
  Authors
POST RL, SEN AK, ROSENTHAL AS.
  Title
A PHOSPHORYLATED INTERMEDIATE IN ADENOSINE TRIPHOSPHATE-DEPENDENT SODIUM AND POTASSIUM TRANSPORT ACROSS KIDNEY MEMBRANES.
  Journal
J Biol Chem 240:1437-45 (1965)
Reference
3  [PMID:2166689]
  Authors
Skou JC.
  Title
The fourth Datta lecture. The energy coupled exchange of Na+ for K+ across the cell membrane. The Na+, K(+)-pump.
  Journal
FEBS Lett 268:314-24 (1990)
DOI:10.1016/0014-5793(90)81278-V
Other DBs
ExplorEnz - The Enzyme Database: 3.6.3.9
IUBMB Enzyme Nomenclature: 3.6.3.9
ExPASy - ENZYME nomenclature database: 3.6.3.9
BRENDA, the Enzyme Database: 3.6.3.9

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