KEGG   ENZYME: 3.6.4.5Help
Entry
EC 3.6.4.5                  Enzyme                                 

Name
minus-end-directed kinesin ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
kinesin ATP phosphohydrolase (minus-end-directed)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
Structurally almost identical to EC 3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules.
History
EC 3.6.4.5 created 2000
Reference
1  [PMID:9288974]
  Authors
Henningsen U, Schliwa M.
  Title
Reversal in the direction of movement of a molecular motor.
  Journal
Nature 389:93-6 (1997)
DOI:10.1038/38022
Reference
2  [PMID:9410876]
  Authors
Sharp DJ, Kuriyama R, Essner R, Baas PW.
  Title
Expression of a minus-end-directed motor protein induces Sf9 cells to form axon-like processes with uniform microtubule polarity orientation.
  Journal
J Cell Sci 110 ( Pt 19):2373-80 (1997)
Reference
3  [PMID:9796817]
  Authors
Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, Vale RD, Fletterick RJ.
  Title
Direction determination in the minus-end-directed kinesin motor ncd.
  Journal
Nature 395:813-6 (1998)
DOI:10.1038/27463
Other DBs
ExplorEnz - The Enzyme Database: 3.6.4.5
IUBMB Enzyme Nomenclature: 3.6.4.5
ExPASy - ENZYME nomenclature database: 3.6.4.5
BRENDA, the Enzyme Database: 3.6.4.5

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