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Entry
EC 3.7.1.11                 Enzyme                                 

Name
cyclohexane-1,2-dione hydrolase;
cyclohexane-1,2-dione acylhydrolase (decyclizing)
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
cyclohexane-1,2-dione acylhydrolase (ring-opening)
Reaction(IUBMB)
cyclohexane-1,2-dione + H2O = 6-oxohexanoate [RN:R05100]
Reaction(KEGG)
Substrate
cyclohexane-1,2-dione [CPD:C06105];
H2O [CPD:C00001]
Product
6-oxohexanoate [CPD:C06102]
Comment
Highly specific; does not act on cyclohexanone or cyclohexane-1,3-dione as substrate.
History
EC 3.7.1.11 created 2009
Pathway
ec00930  Caprolactam degradation
ec01120  Microbial metabolism in diverse environments
Reference
1
  Authors
Harder, J.
  Title
Anaerobic degradation of cyclohexane-1,2-diol by a new Azoarcus species.
  Journal
Arch Microbiol 168:199-204 (1997)
Reference
2
  Authors
Fraas, S., Steinbach, A.K., Tabbert, A., Harder, J., Ermler, U., Tittmann, K., Meyer, A. and Kroneck P.M.H.
  Title
Cyclohexane-1,2-dione hydrolase: A new tool to degrade alicyclic compounds.
  Journal
J Mol Catalysis B: Enzymatic 61:47-49 (2009)
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.11
IUBMB Enzyme Nomenclature: 3.7.1.11
ExPASy - ENZYME nomenclature database: 3.7.1.11
BRENDA, the Enzyme Database: 3.7.1.11

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