| Entry |
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| Name |
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| Class |
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
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| Sysname |
L-kynurenine hydrolase
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| Reaction(IUBMB) |
L-kynurenine + H2O = anthranilate + L-alanine [RN: R00987]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A pyridoxal-phosphate protein. Also acts on 3'-hydroxy-L-kynurenine and some other (3-arylcarbonyl)-alanines.
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| History |
EC 3.7.1.3 created 1965
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| Pathway |
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
JAKOBY WB, BONNER DM. |
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| Title |
Kynureninase from Neurospora: purification and properties. |
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| Journal |
J Biol Chem 205:699-707 (1953) |
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| Reference |
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| Authors |
JAKOBY WB, BONNER DM. |
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| Title |
Kynureninase from Neurospora: interaction of enzyme with substrates, coenzyme, and amines. |
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| Journal |
J Biol Chem 205:709-15 (1953) |
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| Reference |
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| Authors |
KNOX WE. |
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| Title |
The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency. |
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| Journal |
Biochem J 53:379-85 (1953) |
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| Reference |
4 |
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| Authors |
Wiss, O. and Weber, F. |
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| Title |
Die Reindarstellung der Kynureninase. |
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| Journal |
Hoppe-Seyler's Z Physiol Chem 304:232-240 (1956) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.7.1.3 |
| ExPASy - ENZYME nomenclature database: | 3.7.1.3 |
| BRENDA, the Enzyme Database: | 3.7.1.3 |
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