| Entry |
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| Name |
(S)-2-haloacid dehalogenase;
2-haloacid dehalogenase[ambiguous];
2-haloacid halidohydrolase [ambiguous][ambiguous];
2-haloalkanoic acid dehalogenase;
2-haloalkanoid acid halidohydrolase;
2-halocarboxylic acid dehalogenase II;
DL-2-haloacid dehalogenase[ambiguous];
L-2-haloacid dehalogenase;
L-DEX
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| Class |
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
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| Sysname |
(S)-2-haloacid halidohydrolase
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| Reaction(IUBMB) |
(S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide [RN: R03830]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2. [See also EC 3.8.1.9 (R)-2-haloacid dehalogenase, EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting) and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]
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| History |
EC 3.8.1.2 created 1972, modified 2003
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| Pathway |
| ec00361 | Chlorocyclohexane and chlorobenzene degradation |
| ec00625 | Chloroalkane and chloroalkene degradation |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K01560 | 2-haloacid dehalogenase |
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| Genes |
» show all
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| Reference |
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| Authors |
Goldman P, Milne GW, Keister DB. |
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| Title |
Carbon-halogen bond cleavage. 3. Studies on bacterial halidohrolases. |
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| Journal |
J Biol Chem 243:428-34 (1968) |
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| Reference |
2 |
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| Authors |
Motosugi, M., Esaki, N. and Soda, K. |
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| Title |
Preparation and properties of 2-halo acid dehalogenase from Pseudomonas putida. |
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| Journal |
Agric Biol Chem 46:837-838 (1982) |
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| Reference |
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| Authors |
Klages U, Krauss S, Lingens F. |
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| Title |
2-Haloacid dehalogenase from a 4-chlorobenzoate-degrading Pseudomonas spec. CBS 3. |
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| Journal |
Hoppe Seylers Z Physiol Chem 364:529-35 (1983) |
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| Reference |
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| Authors |
Diez A, Prieto MI, Alvarez MJ, Bautista JM, Garrido J, Puyet A. |
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| Title |
Improved catalytic performance of a 2-haloacid dehalogenase from Azotobacter sp. by ion-exchange immobilisation. |
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| Journal |
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| Reference |
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| Authors |
Morsberger FM, Muller R, Otto MK, Lingens F, Kulbe KD. |
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| Title |
Purification and characterization of 2-halocarboxylic acid dehalogenase II from Pseudomonas spec. CBS 3. |
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| Journal |
Biol Chem Hoppe Seyler 372:915-22 (1991) |
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| Reference |
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| Authors |
Kohler R, Brokamp A, Schwarze R, Reiting RH, Schmidt FR. |
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| Title |
Characteristics and DNA-sequence of a cryptic haloalkanoic acid dehalogenase from Agrobacterium tumefaciens RS5. |
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| Journal |
Curr Microbiol 36:96-101 (1998) |
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| Reference |
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| Authors |
Motosugi K, Esaki N, Soda K. |
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| Title |
Bacterial assimilation of D- and L-2-chloropropionates and occurrence of a new dehalogenase. |
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| Journal |
Arch Microbiol 131:179-83 (1982) |
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| Reference |
8 |
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| Authors |
Kurihara, T., Esaki, N. and Soda, K. |
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| Title |
Bacterial 2-haloacid dehalogenases: structures and reaction mechanisms. |
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| Journal |
J Mol Catal, B Enzym 10:57-65 (2000) |
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| Reference |
9 |
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| Authors |
Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N. |
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| Title |
Bacterial 2-haloacid dehalogenases: Structures and catalytic properties. |
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| Journal |
Pure Appl Chem 68:2097-2103 (1996) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.8.1.2 |
| ExPASy - ENZYME nomenclature database: | 3.8.1.2 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 3.8.1.2 |
| BRENDA, the Enzyme Database: | 3.8.1.2 |
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