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Entry
EC 3.8.1.5                  Enzyme                                 

Name
haloalkane dehalogenase;
1-chlorohexane halidohydrolase;
1-haloalkane dehalogenase
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
BRITE hierarchy
Sysname
1-haloalkane halidohydrolase
Reaction(IUBMB)
1-haloalkane + H2O = a primary alcohol + halide [RN:R02337]
Reaction(KEGG)
Substrate
1-haloalkane [CPD:C01872];
H2O [CPD:C00001]
Product
primary alcohol [CPD:C00226];
halide [CPD:C00462]
Comment
Acts on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds.
History
EC 3.8.1.5 created 1989
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec00625  Chloroalkane and chloroalkene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K01563  haloalkane dehalogenase
Genes
KMI: VW41_10305
LAB: LA76x_0649(dhaA)
LAQ: GLA29479_2842(linB)
VOW: A9237_20330
VSH: BSZ05_17590
PCR: Pcryo_1253
PSO: PSYCG_06610
PSPG: AK823_10205
PSYG: AK825_10445
SFR: Sfri_2056 Sfri_3680
SSE: Ssed_1777
SPSW: Sps_02009
PAT: Patl_1915
PSM: PSM_B0300
PART: PARC_b0374(dhaA)
PTD: PTET_b0384(dhaA)
MAQ: Maqu_2428
MHC: MARHY0818(dhmA)
MAD: HP15_2669 HP15_590(dhmA)
AMAL: I607_08090
AMAE: I876_08355
AMAO: I634_08460
AMAD: I636_08890
AMAI: I635_09160
AMAG: I533_08400
AMAC: MASE_07990
AAUS: EP12_08760
GNI: GNIT_0188
GPS: C427_1826
CBU: CBU_1225
CBD: CBUD_1310
CBG: CbuG_0785
CBC: CbuK_1085
GAI: IMCC3135_16825(linB) IMCC3135_16970(dhaA_1) IMCC3135_16985(dhmA2) IMCC3135_17030(dhaA_2) IMCC3135_28350(dhaA_3)
HCH: HCH_05560
ABO: ABO_2415(dhmA)
OAI: OLEAN_C34210(dhmA)
SVA: SVA_0114
BCEN: DM39_1977(dhaA) DM39_2021(dhaA)
RFR: Rfer_2286
POL: Bpro_2447
PNA: Pnap_1997
AAV: Aave_3082
AJS: Ajs_2282
AAA: Acav_2201
ACRA: BSY15_3011(dhlA)
VEI: Veis_2620
DAC: Daci_4809
CTES: O987_10940
RTA: Rta_19770
LIM: L103DPR2_01777(dhlA) L103DPR2_02525(dhmA)
LIH: L63ED372_01363(dhlA)
HYR: BSY239_1724(dhlA)
HYB: Q5W_10125
CBAA: SRAA_1219
CBAB: SMCB_1084
GEO: Geob_2043(linB)
CCX: COCOR_03107(dha) COCOR_05952(dhmA2)
SCL: sce2168(dha)
MLO: mlr5354
PLA: Plav_1611
ATU: Atu6064(dha)
RLE: pRL110536
RLG: Rleg_6597
BJA: blr1087
RBM: TEF_16230
CCR: CC_1175
CAK: Caul_2671
CSE: Cseg_2706
PZU: PHZ_c2250(dhlA)
JAN: Jann_2620
HNE: HNE_0985(dhlA)
SPHK: SKP52_04710(dhmA)
SPHP: LH20_01540
SGI: SGRAN_1300(dhmA)
SPHU: SPPYR_2635(dhmA)
SSAN: NX02_14860
SPKC: KC8_11355
SJP: SJA_C1-19590(linB)
SINB: SIDU_17345
SFLA: SPHFLASMR4Y_01800(dhlA)
BLAS: BSY18_1050 BSY18_475(dhlA)
ELI: ELI_03475
ADO: A6F68_01339(dhmA)
TMO: TMO_0441(dhlA)
PMW: B2K_22145
MTU: Rv1833c Rv2296 Rv2579(dhaA)
MTC: MT1881 MT2353 MT2656(linB)
MTUH: I917_18205
MCQ: BN44_40093 BN44_50246(dhmA) BN44_60039(dhaA)
MCV: BN43_30971 BN43_31543(dhmA) BN43_40253(dhaA)
MCX: BN42_40214(dhmA) BN42_40560(dhaA)
MCZ: BN45_50096 BN45_50630(dhmA) BN45_50969(dhaA)
MLP: MLM_1870
MUL: MUL_3052 MUL_3979(dhaA)
MMC: Mmcs_4949
MKM: Mkms_5037
MJL: Mjls_5330
MLI: MULP_00098(dhaA_1) MULP_04277(dhaA)
MSG: MSMEI_6149(dhmA1) MSMEI_6656(dhaA)
MVA: Mvan_2384
MGI: Mflv_4004
MTHN: 4412656_02462(dhaA_2)
MSTE: MSTE_02831(dhaA)
MTER: 4434518_03970(dhmA)
ASD: AS9A_0181
NFA: NFA_26230
NCY: NOCYR_4142(dhaA)
NNO: NONO_c01140(dhmA1) NONO_c48280(dhmA2) NONO_c72790
REY: O5Y_05410
GPO: GPOL_c45710(dhmA)
TPR: Tpau_2475
STRE: GZL_08308
STRM: M444_06220
SNR: SNOUR_37320(dhmA2)
SLX: SLAV_03125(dhaA)
CFI: Celf_3754
NDK: I601_0825(dhmA_1)
KFL: Kfla_1983
GOB: Gobs_0257
BSD: BLASA_0113(dhmA) BLASA_0238(dhaA)
MMAR: MODMU_0271(dhaA)
AMD: AMED_0191(dhaA) AMED_6398(dhaA)
AMM: AMES_0187(dhaA) AMES_6306(dhaA)
AMZ: B737_0188(dhaA) B737_6306(dhaA)
AOI: AORI_0188(dhaA) AORI_2120(dhaA)
AJA: AJAP_01000(dhmA) AJAP_28925(dhmA2)
AMQ: AMETH_0214(dhaA) AMETH_5325(dhaA)
ACTI: UA75_12695
ACAD: UA74_12615
SAQ: Sare_3197
CAI: Caci_6469
AYM: YM304_07150(dhaA) YM304_31380(dhmA)
PBU: L21SP3_00896(dhmA_1) L21SP3_01652(dhmA_2)
VBL: L21SP4_02206(dhmA_2) L21SP4_02395(dhmA_3)
ABAC: LuPra_02086(dhaA)
GAU: GAU_1241
GBA: J421_3139
TMAR: MARIT_0441(dhaA)
HME: HFX_2390(mhpC)
HTU: Htur_1907
SALI: L593_05270
LOKI: Lokiarch_30800(dhlA)
 » show all
Taxonomy
Reference
1  [PMID:4019411]
  Authors
Keuning S, Janssen DB, Witholt B.
  Title
Purification and characterization of hydrolytic haloalkane dehalogenase from Xanthobacter autotrophicus GJ10.
  Journal
J Bacteriol 163:635-9 (1985)
  Sequence
Reference
2  [PMID:3667524]
  Authors
Scholtz R, Leisinger T, Suter F, Cook AM.
  Title
Characterization of 1-chlorohexane halidohydrolase, a dehalogenase of wide substrate range from an Arthrobacter sp.
  Journal
J Bacteriol 169:5016-21 (1987)
DOI:10.1128/JB.169.11.5016-5021.1987
Reference
3  [PMID:3624201]
  Authors
Yokota T, Omori T, Kodama T.
  Title
Purification and properties of haloalkane dehalogenase from Corynebacterium sp. strain m15-3.
  Journal
J Bacteriol 169:4049-54 (1987)
DOI:10.1128/JB.169.9.4049-4054.1987
Other DBs
ExplorEnz - The Enzyme Database: 3.8.1.5
IUBMB Enzyme Nomenclature: 3.8.1.5
ExPASy - ENZYME nomenclature database: 3.8.1.5
UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.5
BRENDA, the Enzyme Database: 3.8.1.5
CAS: 95990-29-7

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