KEGG   ENZYME: 3.8.1.7Help
Entry
EC 3.8.1.7                  Enzyme                                 

Name
4-chlorobenzoyl-CoA dehalogenase
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
BRITE hierarchy
Sysname
4-chlorobenzoyl CoA chlorohydrolase
Reaction(IUBMB)
4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride [RN:R04101]
Reaction(KEGG)
R04101;
(other) R08118
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Substrate
4-chlorobenzoyl-CoA [CPD:C06387];
H2O [CPD:C00001]
Product
4-hydroxybenzoyl CoA;
chloride [CPD:C00698]
Comment
Specific for dehalogenation at the 4-position. Can dehalogenate substrates bearing fluorine, chlorine, bromine and iodine in the 4-position. This enzyme is part of the bacterial 2,4-dichlorobenzoate degradation pathway.
History
EC 3.8.1.7 created 1999
Pathway
ec00364  Fluorobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14418  4-chlorobenzoyl-CoA dehalogenase
Reference
1  [PMID:1610806]
  Authors
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D.
  Title
Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
  Journal
Biochemistry 31:5605-10 (1992)
  Sequence
Reference
2  [PMID:7918379]
  Authors
Crooks GP, Copley SD.
  Title
Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1.
  Journal
Biochemistry 33:11645-9 (1994)
Other DBs
ExplorEnz - The Enzyme Database: 3.8.1.7
IUBMB Enzyme Nomenclature: 3.8.1.7
ExPASy - ENZYME nomenclature database: 3.8.1.7
UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.7
BRENDA, the Enzyme Database: 3.8.1.7
CAS: 141583-18-8

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