KEGG   ENZYME: 4.1.1.28Help
Entry
EC 4.1.1.28                 Enzyme                                 

Name
aromatic-L-amino-acid decarboxylase;
DOPA decarboxylase;
tryptophan decarboxylase;
hydroxytryptophan decarboxylase;
L-DOPA decarboxylase;
aromatic amino acid decarboxylase;
5-hydroxytryptophan decarboxylase;
aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
aromatic-L-amino-acid carboxy-lyase
Reaction(IUBMB)
(1) L-dopa = dopamine + CO2 [RN:R02080];
(2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2 [RN:R02701]
Reaction(KEGG)
Substrate
L-dopa [CPD:C00355];
5-hydroxy-L-tryptophan [CPD:C00643]
Product
dopamine [CPD:C03758];
CO2 [CPD:C00011];
5-hydroxytryptamine [CPD:C00780]
Comment
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
History
EC 4.1.1.28 created 1961 (EC 4.1.1.26 and EC 4.1.1.27 both created 1961 and incorporated 1972)
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00380  Tryptophan metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec00965  Betalain biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01593  aromatic-L-amino-acid/L-tryptophan decarboxylase
Genes
HSA: 1644(DDC)
PTR: 463409(DDC)
PPS: 100971531(DDC)
GGO: 101145222(DDC)
PON: 100435277(DDC)
NLE: 100597933(DDC)
MCC: 693677(DDC)
MCF: 102119567(DDC)
CSAB: 103226076(DDC)
RRO: 104657651(DDC)
RBB: 108527366(DDC)
CJC: 100402255(DDC)
SBQ: 101040684(DDC)
MMU: 13195(Ddc)
RNO: 24311(Ddc)
CGE: 100761742(Ddc)
NGI: 103746991(Ddc)
HGL: 101697555(Ddc)
CCAN: 109689534(Ddc)
OCU: 100355492(DDC)
TUP: 102499553(DDC)
CFA: 606852(DDC)
AML: 100475392(DDC)
UMR: 103674553(DDC)
ORO: 101364177(DDC)
FCA: 101082989(DDC)
PTG: 102955370(DDC)
AJU: 106968187(DDC)
BTA: 280762(DDC)
BOM: 102287020(DDC)
BIU: 109558177(DDC)
PHD: 102325577(DDC) 102325580
CHX: 102169726(DDC)
OAS: 101106765(DDC)
SSC: 396857(DDC)
CFR: 102513068(DDC)
CDK: 105105292(DDC)
BACU: 102999539(DDC)
LVE: 103080634(DDC)
OOR: 101290071(DDC)
ECB: 100052557(DDC)
EPZ: 103558736 103563419(DDC)
EAI: 106822940(DDC)
MYB: 102254659(DDC)
MYD: 102774614(DDC)
HAI: 109388356(DDC)
RSS: 109447363(DDC)
PALE: 102893985(DDC)
LAV: 100677538(DDC)
TMU: 101348227
MDO: 100030001(DDC)
SHR: 100917570(DDC)
OAA: 100074589(DDC)
GGA: 420947(DDC)
MGP: 100542576(DDC)
CJO: 107309491(DDC)
APLA: 101796508(DDC)
ACYG: 106036562(DDC)
TGU: 100226623(DDC)
GFR: 102032520(DDC)
FAB: 101811896(DDC)
PHI: 102104958(DDC)
PMAJ: 107216322(DDC)
CCAE: 111925383(DDC)
CCW: 104685862(DDC)
FPG: 101922826(DDC)
FCH: 102059671(DDC)
EGZ: 104126196(DDC)
AAM: 106492855(DDC)
ASN: 102375703(DDC)
AMJ: 106736839(DDC)
PSS: 102452351(DDC)
CMY: 102937578(DDC)
CPIC: 101939746(DDC)
ACS: 100564794(ddc)
PVT: 110085760(DDC)
PBI: 103055744(DDC)
GJA: 107121867(DDC)
XLA: 100126640(ddc.L)
XTR: 496742(ddc)
NPR: 108788303(DDC)
DRE: 406651(ddc)
SANH: 107657571(ddc) 107704081
CCAR: 109066248 109071918(ddc)
IPU: 108275746(ddc)
AMEX: 103039119(ddc)
TRU: 101070663(ddc)
LCO: 104939491(ddc)
NCC: 104957402
MZE: 101472888(ddc)
OLA: 100301599(ddc)
XMA: 102226428(ddc)
PRET: 103478360(ddc)
NFU: 107378764(ddc)
KMR: 108232186(ddc)
CSEM: 103388766(ddc)
LCF: 108888820(ddc)
SDU: 111227826(ddc)
HCQ: 109531054(ddc)
BPEC: 110171777(ddc)
MALB: 109958276(ddc)
ELS: 105025918(ddc)
SFM: 108940501(ddc)
CMK: 103181195(ddc)
CIN: 100101815(hdcl)
APLC: 110989624
SKO: 100374376
DME: Dmel_CG10697(Ddc)
DPO: Dpse_GA10503(Dpse_Ddc)
DPE: 6598065
DSI: Dsimw501_GD21778(Dsim_Ddc)
DWI: 6644461
DVI: Dvir_GJ17995(Dvir_Ddc)
AAG: 5563940
CEL: CELE_C05D2.3(basl-1) CELE_ZK829.2(hdl-1)
TSP: Tsp_00610
EGL: EGR_09525
ATH: AT2G20340(AAS)
LJA: Lj0g3v0211149.1(Lj0g3v0211149.1) Lj1g3v4528440.1(Lj1g3v4528440.1) Lj6g3v1679480.1(Lj6g3v1679480.1)
CSV: 101205061
CMO: 103489832
MCHA: 111022679
RCU: 8266698
CANN: 107842494(TDC2) 107878308
DOSA: Os07t0437500-01(Os07g0437500) Os08t0140300-01(Os08g0140300) Os08t0140500-00(Os08g0140500) Os10t0400500-00(Os10g0400500)
ATS: 109748394(LOC109748394) 109749204(LOC109749204) 109751651(LOC109751651) 109754049(LOC109754049) 109782055(LOC109782055)
SMO: SELMODRAFT_169665(TYDC5-2) SELMODRAFT_84876(TYDC5-1)
CRE: CHLREDRAFT_116869(DDC1)
APRO: F751_5176
NCR: NCU08275
NTE: NEUTE1DRAFT128600(NEUTE1DRAFT_128600)
SSCK: SPSK_03252
MAW: MAC_06737
MAJ: MAA_01165
CMT: CCM_04742
MBE: MBM_06276
ANI: AN2357.2
ANG: ANI_1_2316014(An01g02000)
ABE: ARB_03722
TVE: TRV_07554
PTE: PTT_10253
CNE: CND00950
CNB: CNBD5350
ABP: AGABI1DRAFT119334(AGABI1DRAFT_119334)
ABV: AGABI2DRAFT185212(AGABI2DRAFT_185212)
MGL: MGL_3372
SMIN: v1.2.008729.t1(symbB.v1.2.008729.t1)
SPAR: SPRG_03246
YPE: YPO1193
YPK: y2996(dcd)
YPH: YPC_3018
YPA: YPA_0905
YPN: YPN_2783
YPM: YP_0943(dcd1)
YPZ: YPZ3_1100
YPD: YPD4_1061
YPX: YPD8_1086
YPW: CH59_650
YPJ: CH55_1355
YPV: BZ15_2363
YPL: CH46_3938
YPS: YPTB1234
YPO: BZ17_1292
YPY: YPK_2867
YPB: YPTS_1322
YPQ: DJ40_1004
YPU: BZ21_503
YPR: BZ20_754
YPC: BZ23_833
YPF: BZ19_633
YRU: BD65_352
SRL: SOD_c40120(ddc)
PPU: PP_2552
PPF: Pput_3163
PPT: PPS_2093
PPI: YSA_00462
PPX: T1E_3359
PPUH: B479_10915
PPUT: L483_10035
PPUN: PP4_33460
PPUD: DW66_2355
PMON: X969_08790
PMOT: X970_08450
PFC: PflA506_1055(ddc)
PFB: VO64_4209
PEN: PSEEN2370
PSEC: CCOS191_3137(ELI5)
NOC: Noc_2983
DVU: DVU0867
DVL: Dvul_2115
DVM: DvMF_2916
DDE: Dde_1124
MLO: mll0712
ARA: Arad_0017
SHZ: shn_28130
NWI: Nwi_1102
XAU: Xaut_0071
MET: M446_1957
MNO: Mnod_1238
MAQU: Maq22A_c11740(gadB)
RVA: Rvan_3231
RBM: TEF_10700
SIL: SPO3687
JAN: Jann_3501
PGD: Gal_00109
RHC: RGUI_0736
SPSE: SULPSESMR1_00270(ddc)
RFA: A3L23_05009(ddc)
SALU: DC74_159
SALL: SAZ_01240
STRE: GZL_08019
GOB: Gobs_3209
BSD: BLASA_2287(tdcA)
MMAR: MODMU_3399(ELI)
SEN: SACE_2888
PDX: Psed_3994
PSEA: WY02_04890
AMI: Amir_5685
SESP: BN6_68200
KAL: KALB_5849
ACTI: UA75_21780
ACAD: UA74_21300
AHG: AHOG_18795(ddc2)
RXY: Rxyl_1038
CAU: Caur_2842
CAG: Cagg_1126
MRB: Mrub_1738
GES: VT84_23180(ddc)
SUS: Acid_1182
ABAC: LuPra_06070(ddc_2)
GAU: GAU_3087
DORI: FH5T_14760
IAL: IALB_2412
MRO: MROS_1175
CABY: Cabys_2336
 » show all
Taxonomy
Reference
1  [PMID:4536745]
  Authors
Christenson JG, Dairman W, Udenfriend S.
  Title
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).
  Journal
Proc Natl Acad Sci U S A 69:343-7 (1972)
DOI:10.1073/pnas.69.2.343
Reference
2  [PMID:14466899]
  Authors
LOVENBERG W, WEISSBACH H, UDENFRIEND S.
  Title
Aromatic L-amino acid decarboxylase.
  Journal
J Biol Chem 237:89-93 (1962)
Reference
3  [PMID:18871240]
  Authors
McGILVERY RW, COHEN PP
  Title
The decarboxylation of L-phenylalanine by Streptococcus faecalis R.
  Journal
J Biol Chem 174:813-6 (1948)
Reference
4  [PMID:14054806]
  Authors
SEKERIS CE
  Title
[ON TYROSINE METABOLISM IN INSECTS. XII. PURIFICATION, PROPERTIES AND SUBSTRATE SPECIFICITY OF DOPA-DECARBOXYLASE].
  Journal
Hoppe Seylers Z Physiol Chem 332:70-8 (1963)
Reference
5  [PMID:13462983]
  Authors
WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S.
  Title
Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation.
  Journal
J Biol Chem 227:617-24 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.28
IUBMB Enzyme Nomenclature: 4.1.1.28
ExPASy - ENZYME nomenclature database: 4.1.1.28
BRENDA, the Enzyme Database: 4.1.1.28
CAS: 9042-64-2

DBGET integrated database retrieval system