KEGG   ENZYME: 4.1.1.3Help
Entry
EC 4.1.1.3                  Enzyme                                 

Name
oxaloacetate decarboxylase;
oxaloacetate beta-decarboxylase;
oxalacetic acid decarboxylase;
oxalate beta-decarboxylase;
oxaloacetate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
oxaloacetate carboxy-lyase (pyruvate-forming)
Reaction(IUBMB)
oxaloacetate = pyruvate + CO2 [RN:R00217]
Reaction(KEGG)
R00217;
(other) R00995
Show
Substrate
oxaloacetate [CPD:C00036]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011]
Comment
The enzyme from Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn2+.
History
EC 4.1.1.3 created 1961, modified 1986, modified 2000
Pathway
ec00620  Pyruvate metabolism
ec01100  Metabolic pathways
Orthology
K01003  oxaloacetate decarboxylase
K01571  oxaloacetate decarboxylase, alpha subunit
K01572  oxaloacetate decarboxylase, beta subunit
K01573  oxaloacetate decarboxylase, gamma subunit
Genes
EFE: EFER_0028(oadB) EFER_0029(oadA) EFER_0030(oadG)
STY: STY0063(oadB) STY0064(oadA) STY0065(oadG) STY3531(oadB) STY3532(oadA) STY3533(oadG)
STT: t0056(oadB) t0057(oadA) t0058(oadG) t3266(oadB) t3267(oadA) t3268(oadG)
SEX: STBHUCCB_34540 STBHUCCB_34550 STBHUCCB_34560 STBHUCCB_650 STBHUCCB_660 STBHUCCB_670
SENT: TY21A_00290 TY21A_00295 TY21A_00300 TY21A_16565 TY21A_16570 TY21A_16575
STM: STM0054 STM0055 STM0056 STM0766(dcoC) STM0768(dcoB) STM3351(oadB) STM3352(oadA) STM3353(oadG)
SEO: STM14_0064 STM14_0065 STM14_0066 STM14_0890(dcoC) STM14_0892(dcoB) STM14_4043(oadB) STM14_4044(oadA) STM14_4045(oadG)
SEV: STMMW_00551 STMMW_00561 STMMW_00571 STMMW_08181 STMMW_08191 STMMW_08201 STMMW_33501 STMMW_33511
SEY: SL1344_0055 SL1344_0056 SL1344_0057(oadG) SL1344_0743(dcoC) SL1344_0744(dcoA) SL1344_0745(dcoB) SL1344_3323(oadB2) SL1344_3324(oadA2) SL1344_3325
SEM: STMDT12_C00550 STMDT12_C00560 STMDT12_C00570 STMDT12_C08190 STMDT12_C08200 STMDT12_C08210 STMDT12_C34090 STMDT12_C34100 STMDT12_C34110
SEF: UMN798_0060(oadB2) UMN798_0061(oadB2) UMN798_0062(oadA2) UMN798_0063(oadG) UMN798_0831(oadG2) UMN798_0832(oadA2) UMN798_0833(oadB2) UMN798_3643(oadB2) UMN798_3646
SEND: DT104_00551(oadB2) DT104_07831(dcoA) DT104_07841(dcoB) DT104_33441 DT104_33451(oadA2)
SPT: SPA0055(oadB) SPA0056(oadA) SPA0057(oadG) SPA3218(oadB) SPA3219(oadA) SPA3220(oadG)
SEI: SPC_0058(oadB) SPC_0059(oadA) SPC_0060(oadG) SPC_0762(oadG) SPC_0763(oadA) SPC_0764(oadB) SPC_3421(oadB) SPC_3422(oadA) SPC_3423(oadG)
SEC: SCH_0048(oadB) SCH_0049(oadA) SCH_0050(oag3) SCH_0764(oadG) SCH_0765(oadA) SCH_0766(oadB) SCH_3289(oadB) SCH_3290(oadA) SCH_3291(oadG)
SEG: SG0057 SG0058 SG0059 SG0744(oadG2) SG0745(oadA2) SG3241(oadB3) SG3242 SG3243
KPU: KP1_4950(oadB) KP1_4952(oadA) KP1_4953(oadC)
KPT: VK055_2543(oadG) VK055_2544(oadA) VK055_2545(oadB) VK055_3839(oadG2) VK055_3840(oadA2) VK055_3841(oadB2)
KPE: KPK_0483(oadG_2) KPK_0484(oadA_2) KPK_0485(oadB_2) KPK_4717(oadG_1) KPK_4718(oadA_1) KPK_4719(oadB_1)
KPX: PMK1_01144(oadB) PMK1_01145 PMK1_01146(oadG)
KPNK: BN49_0482(oadG) BN49_0483(dcoA) BN49_0484(oadB_C) BN49_4308(oadG2) BN49_4309(oadA) BN49_4310(oadB_N) BN49_4529
HDU: HD_0782(oadB) HD_0783(oadA) HD_0784(oadG)
HPAZ: K756_01235
HSO: HS_0201(oadG) HS_0202(oadA) HS_0203(oadB)
PMV: PMCN06_1679(oadG) PMCN06_1680(oadA) PMCN06_1681(oadB)
PMP: Pmu_16720(oadG) Pmu_16730(oadA) Pmu_16740(oadB)
PMUL: DR93_275 DR93_276(oadA) DR93_277(oadB)
PDAG: 4362423_01741(oadG) 4362423_01742(oadA) 4362423_01743(oadB)
MSU: MS0038(oadB) MS0039(oadA) MS0040(oadG)
MHX: MHH_c10410(oadB) MHH_c10420(oadA) MHH_c10430(oadG)
APL: APL_1375(oadG) APL_1376(oadA) APL_1377(oadB)
APJ: APJL_1393 APJL_1394(oadA) APJL_1395(oadB)
APA: APP7_1426(oadG) APP7_1427(oadA) APP7_1428(oadB)
VCR: VC395_0566 VC395_0567(oadA-1) VC395_0568(oadB-1) VC395_0809(oadB-2) VC395_0810(oadA-2) VC395_0811
VCM: VCM66_0507 VCM66_0508(oadA-1) VCM66_0509(oadB-1) VCM66_0750(oadB-2) VCM66_0751(oadA-2) VCM66_0752
VNI: VIBNI_A0153(oadA) VIBNI_A0154(oadB2)
VSC: VSVS12_02745(oadB) VSVS12_02746(oadA) VSVS12_02747(oadG)
VTA: A0109(oadG) A0110(oadA) A0111(oadB) B0177(oadB) B0178(oadA)
VFI: VF_0539(oadA) VF_0540(oadB) VF_2592(oadC)
PPR: PBPRA2298(T3267) PBPRA2299(T3266) PBPRA3050(T3266) PBPRA3051(HD0783) PBPRA3052
PAE: PA4872
PAEV: N297_5042
PAEI: N296_5042
PNC: NCGM2_0654(bcpA)
PAEB: NCGM1900_5613(bcpA)
PAEP: PA1S_26460
PAEM: U769_26725
PAEL: T223_26920
PAEG: AI22_07535
PAEC: M802_5040
PAEO: M801_4907
PPSE: BN5_0574
PPU: PP_1389
PPF: Pput_4334
PPT: PPS_4264
PPI: YSA_02878
PPUH: B479_21440
PPUT: L483_26510
PPUN: PP4_09380
PPUD: DW66_4652
PMON: X969_20985
PMOT: X970_20620
PSB: Psyr_1256
PSYR: N018_19415
PSP: PSPPH_1328(bcpA)
PFL: PFL_2455
PPRO: PPC_2494
PFS: PFLU_3105
PFB: VO64_0355
PMAN: OU5_5864
PEN: PSEEN4356
PKC: PKB_5190
PSES: PSCI_0548
PSEM: TO66_12015
PSOS: POS17_2450
PANR: A7J50_2850
PSIL: PMA3_17455
SVO: SVI_3159(oadB) SVI_3160(oadA) SVI_3161(oadG)
ILO: IL1734(oadB) IL1735(oadA) IL1736(oadG)
CPS: CPS_1048(oadG) CPS_1049(oadA) CPS_1050(oadB)
PHA: PSHAa0538(oadG) PSHAa0539(oadA) PSHAa0540(oadB)
PSM: PSM_A0585(oadG) PSM_A0586(oadA) PSM_A0587(oadB)
PTN: PTRA_a0609(oadG) PTRA_a0611(oadA) PTRA_a0612(oadB)
PEA: PESP_a0733(oadG) PESP_a0735(oadA) PESP_a0737(oadB)
PSPO: PSPO_a2228(oadB) PSPO_a2229(oadA) PSPO_a2230
PART: PARC_a3300(oadB) PARC_a3301(oadA) PARC_a3302(oadG)
PTU: PTUN_a1099(oadG) PTUN_a1101(oadA) PTUN_a1102(oadB)
PNG: PNIG_a0649(oadG) PNIG_a0651(oadA) PNIG_a0652(oadB)
PTD: PTET_a0647(oadG) PTET_a0648(oadA) PTET_a0649(oadB)
MBS: MRBBS_1499(oadG) MRBBS_1500(oadA1) MRBBS_1501(oadB)
GNI: GNIT_1387(pycB) GNIT_2323(oadB) GNIT_2324(oadA) GNIT_2325(oadG)
SALH: HMF8227_02229(oadB) HMF8227_02230(oadA) HMF8227_02231(oadG)
MCA: MCA2479(oadB) MCA2480(oadA) MCA2481(oadC)
MAH: MEALZ_0543(oadB) MEALZ_0544(oadA) MEALZ_2663
CZA: CYCME_1869(oadB) CYCME_1870(oadA) CYCME_1871(oadG)
HEL: HELO_3734(oadB) HELO_3735(oadA) HELO_3736(oadC)
HBE: BEI_3145(oadB) BEI_3146(oadA) BEI_3147(oadG)
EME: CEM_228
ABO: ABO_0843(oadG) ABO_0844(oadA) ABO_0845(oadB)
ADI: B5T_01559 B5T_01560(oadA) B5T_01561(oadB)
OAI: OLEAN_C28130(oadB) OLEAN_C28140(oadA) OLEAN_C28150(oadG)
VOK: COSY_0772(oadB) COSY_0773(oadA)
EBH: BSEPE_1238(oadB) BSEPE_1239(oadA) BSEPE_1240(oadC)
ENM: EBS_1205(oadB) EBS_1206 EBS_1207(oadC)
BXE: Bxe_B2147
BXB: DR64_4476
BPE: BP0884
BPC: BPTD_0880
BPER: BN118_1464
BPET: B1917_2940
BPEU: Q425_8190
BPA: BPP2170
BPAR: BN117_1329
BBR: BB1567
RGE: RGE_11560
EBA: ebA314(xccA)
TCL: Tchl_1582
CPIN: CPIN18020_1008(oadB) CPIN18020_1010(oadG)
GLO: Glov_1820
GBM: Gbem_1454(oadA)
GEO: Geob_0239(oadA)
GEM: GM21_2799
DPS: DP0687
DSF: UWK_01573
DML: Dmul_03490(oadB1) Dmul_10450(oadB2) Dmul_25040(gcdB)
DAL: Dalk_1191
DAT: HRM2_06280(oadB1) HRM2_38530(oadB2) HRM2_38660(oadB3)
DTO: TOL2_C10000(oadB)
DBR: Deba_2621
BJA: bll5266
BRA: BRADO3250
BBT: BBta_4901
BRS: S23_30220
AOL: S58_31240
BRAD: BF49_6364
BRO: BRAD285_3147(OAD)
RPA: RPA3174
RPB: RPB_2368
RPC: RPC_3351
RPD: RPD_3092
RPE: RPE_3438
RPT: Rpal_3584
RSU: NHU_02470
RHC: RGUI_1051
SMAZ: LH19_02180
SPHD: HY78_18135
SSY: SLG_06500
AAY: WYH_03204(cfiA)
RRF: F11_18790
MAGQ: MGMAQ_2139
SPY: SPy_1174 SPy_1191(oadA)
SPZ: M5005_Spy0894(oadA2) M5005_Spy0903(oadB) M5005_Spy0909(oadA1)
SPYM: M1GAS476_0950(oadA2) M1GAS476_0959(oadB) M1GAS476_0965(oadA1)
SPYA: A20_0931(pycB) A20_0940(gcdB) A20_0946(pycB)
SPK: MGAS9429_Spy1011(oadA1)
STG: MGAS15252_0892(oadA.1) MGAS15252_0901(oadB.2) MGAS15252_0907(oadA.2)
STX: MGAS1882_0887(oadA.1) MGAS1882_0896(oadB.2) MGAS1882_0902(oadA.2)
SMU: SMU_1017(oadB) SMU_1023(pycB)
SMC: SmuNN2025_1000(pycB) SmuNN2025_1006(oadB)
SMJ: SMULJ23_1009(pycB) SMULJ23_1015(oadB)
SMUA: SMUFR_0887(oadB) SMUFR_0892(oadA)
SEZ: Sez_0992(oadB)
SEZO: SeseC_01292(oadB) SeseC_01300(pycB)
SUB: SUB1584 SUB1591(gcdB)
SDS: SDEG_0982(oadA1) SDEG_0989(oadB) SDEG_0999(oadA2)
SDC: SDSE_1011(oadA) SDSE_1018(oadB) SDSE_1028
STK: STP_0112(gcdB) STP_0118
LSA: LCA_1222(oadA) LCA_1229(oadB)
LCB: LCABL_20790(oadA) LCABL_20860(oadB)
LCW: BN194_20290(pycB) BN194_20360(gcdB)
LRH: LGG_01912(oadA) LGG_01918(oadB)
LRL: LC705_01900(oadA) LC705_01906(oadB)
EFL: EF62_0376(oadA) EF62_0383(oadD)
EFI: OG1RF_12562(oadA) OG1RF_12569(gcdB)
EFS: EFS1_2717(oadA) EFS1_2724(oadB)
EFN: DENG_03209(oadA) DENG_03217(oadB)
EMU: EMQU_1781 EMQU_1788(gcdB)
THL: TEH_07910
CRN: CAR_c13490(oadB) CAR_c13520(oadA)
CARC: NY10_727
CACE: CACET_c19570(pycB) CACET_c36760(gcdB)
ASM: MOUSESFB_1096(oadB) MOUSESFB_1099(pycB)
ASB: RATSFB_1016(oadB) RATSFB_1019(pycB)
CCE: Ccel_1736
ESR: ES1_14170
ESU: EUS_07390
CSS: Cst_c06330(gcdB) Cst_c11010(pycB) Cst_c12080(oadB)
CSD: Clst_0601(oadB1) Clst_1052(oadA) Clst_1166(oadB2)
RUS: RBI_I01165(gcdB) RBI_I01193(oadA)
HSC: HVS_08280 HVS_11090(gcdB2)
BPB: bpr_I1229 bpr_I1230(oadA)
HSD: SD1D_0451 SD1D_1113(gcdB) SD1D_1114(pycB)
ERT: EUR_12060
ERA: ERE_26940
EAC: EAL2_808p06910(gcdB) EAL2_808p06940(pycB)
SWO: Swol_0558
SLP: Slip_0422
DSY: DSY2367
DHD: Dhaf_3508
DRM: Dred_1064
DAE: Dtox_2603
PTH: PTH_1174
DAU: Daud_1015
HMO: HM1_0282(oadA)
CTHM: CFE_0943
TTE: TTE0252(OadB) TTE1208(PycA) TTE1336(PycA2)
TIT: Thit_1131
TKI: TKV_c02030(gcdB) TKV_c12580(pycB)
CHY: CHY_1999(oadA)
MTA: Moth_1525
ADG: Adeg_1284
CSC: Csac_1883
ATE: Athe_1319
TTM: Tthe_1352
PED: ING2D1G_0482(pycB) ING2D1G_1321(gcdB1) ING2D1G_1425(gcdB3)
VPR: Vpar_0396
MED: MELS_0064
MHG: MHY_24950
AIN: Acin_0943(oadA)
ERH: ERH_0755(oadA) ERH_0758(oadB)
CGV: CGLAU_03210(cfiA)
ROP: ROP_29690
MGG: MPLG2_1841(gcdB)
BSD: BLASA_1293(xccA)
RXY: Rxyl_1571
ELE: Elen_2542
GPA: GPA_07910
AEQ: AEQU_0607
CBAC: JI75_08470
GVI: gll0879
GLJ: GKIL_2432(pycB)
RCA: Rcas_0953
TRO: trd_1683
STI: Sthe_2821
ATM: ANT_05830(mmdB)
OBG: Verru16b_01940(madB)
IPA: Isop_1585
KST: KSMBR1_1801(mmdB)
TPW: TPANIC_0055(oadG) TPANIC_0056(oadA) TPANIC_0057(oadB)
TPP: TPASS_0056(oadA) TPASS_0057(oadB)
TPU: TPADAL_0055(oadG) TPADAL_0056(oadA) TPADAL_0057(oadB)
TPO: TPAMA_0055(oadG) TPAMA_0056(oadA) TPAMA_0057(oadB)
TPC: TPECDC2_0055(oadG) TPECDC2_0056(oadA) TPECDC2_0057(oadB)
TPG: TPEGAU_0055(oadG) TPEGAU_0056(oadA) TPEGAU_0057(oadB)
TPM: TPESAMD_0055(oadG) TPESAMD_0056(oadA) TPESAMD_0057(oadB)
TPB: TPFB_0055(oadG) TPFB_0056(oadA) TPFB_0057(oadB)
TPL: TPCCA_0055(oadG) TPCCA_0056(oadA) TPCCA_0057(oadB)
FNU: FN1376
LBA: Lebu_2280
FSC: FSU_2086
BACC: BRDCF_p1211(gcdB)
PGN: PGN_0504
PGT: PGTDC60_0691(mmdB)
PMUC: ING2E5A_1041(oadB2-1) ING2E5A_1042(oadB2-2) ING2E5A_1825(oadB) ING2E5A_1827(4.1.1.3)
TFO: BFO_0962(oadB)
APS: CFPG_533
PRU: PRU_1644
AFD: Alfi_2937
BLQ: L21SP5_03928(gcdB)
PPH: Ppha_0944
PAA: Paes_0917
CTS: Ctha_0175
IAL: IALB_1429(oadB)
MRO: MROS_0647
DTN: DTL3_1241(oadB) DTL3_1286(pycB)
CEX: CSE_10380
CABY: Cabys_114
PHO: PH1283(PH1283)
PAB: PAB1772
PFU: PF0674
PFI: PFC_02530
PYN: PNA2_1857
PYS: Py04_0757
TKO: TK1625
TON: TON_0038
TGA: TGAM_2029(mmdB)
TSI: TSIB_1537
THE: GQS_05065
THA: TAM4_214
THM: CL1_0657
TLT: OCC_03162
THS: TES1_0182
TNU: BD01_2084
TEU: TEU_04770
PPAC: PAP_07985
ABI: Aboo_1366
 » show all
Taxonomy
Reference
1  [PMID:7016536]
  Authors
Dimroth P.
  Title
Characterization of a membrane-bound biotin-containing enzyme: oxaloacetate decarboxylase from Klebsiella aerogenes.
  Journal
Eur J Biochem 115:353-8 (1981)
DOI:10.1111/j.1432-1033.1981.tb05245.x
Reference
2  [PMID:7037395]
  Authors
Dimroth P.
  Title
The role of biotin and sodium in the decarboxylation of oxaloacetate by the membrane-bound oxaloacetate decarboxylase from Klebsiella aerogenes.
  Journal
Eur J Biochem 121:435-41 (1982)
DOI:10.1111/j.1432-1033.1982.tb05806.x
Reference
3
  Authors
Herbert, D.
  Title
Oxalacetic carboxylase of Micrococcus lysodeikticus.
  Journal
Methods Enzymol 1:753-757 (1955)
Reference
4  [PMID:14205502]
  Authors
HORTON AA, KORNBERG HL.
  Title
OXALOACETATE 4-CARBOXY-LYASE FROM PSEUDOMONAS OVALIS CHESTER.
  Journal
Biochim Biophys Acta 89:381-3 (1964)
Reference
5  [PMID:5972993]
  Authors
Schmitt A, Bottke I, Siebert G.
  Title
[Properties of oxaloacetate decarboxylase from codfish muscles]
  Journal
Hoppe Seylers Z Physiol Chem 347:18-34 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.3
IUBMB Enzyme Nomenclature: 4.1.1.3
ExPASy - ENZYME nomenclature database: 4.1.1.3
BRENDA, the Enzyme Database: 4.1.1.3
CAS: 9024-98-0

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