KEGG   ENZYME: 4.1.1.41Help
Entry
EC 4.1.1.41                 Enzyme                                 

Name
(S)-methylmalonyl-CoA decarboxylase;
propionyl-CoA carboxylase (incorrect);
propionyl coenzyme A carboxylase (incorrect);
methylmalonyl-coenzyme A decarboxylase;
(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase (incorrect);
(S)-methylmalonyl-CoA carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)
Reaction(IUBMB)
(S)-methylmalonyl-CoA = propanoyl-CoA + CO2 [RN:R00923]
Reaction(KEGG)
Substrate
(S)-methylmalonyl-CoA [CPD:C00683]
Product
propanoyl-CoA [CPD:C00100];
CO2 [CPD:C00011]
Comment
The enzyme from Veillonella alcalescens is a biotinyl-protein, requires Na+ and acts as a sodium pump.
History
EC 4.1.1.41 created 1972, modified 1983, modified 1986
Pathway
ec00640  Propanoate metabolism
Orthology
K11264  methylmalonyl-CoA decarboxylase
K18426  ethylmalonyl-CoA/methylmalonyl-CoA decarboxylase
Genes
HSA: 55862(ECHDC1)
PTR: 745395(ECHDC1)
PPS: 100992035(ECHDC1)
GGO: 101134705(ECHDC1)
PON: 100173900(ECHDC1)
NLE: 100592701(ECHDC1)
MCC: 712072(ECHDC1)
MCF: 102132641(ECHDC1)
CSAB: 103240408(ECHDC1)
RRO: 104665004(ECHDC1)
RBB: 108534272(ECHDC1)
CJC: 100400374(ECHDC1)
SBQ: 101054287(ECHDC1)
MMU: 52665(Echdc1)
RNO: 361465(Echdc1)
CGE: 100764713(Echdc1)
NGI: 103734575(Echdc1)
HGL: 101721458(Echdc1)
CCAN: 109686373(Echdc1)
OCU: 100339488(ECHDC1)
TUP: 102478961 102498422(ECHDC1)
CFA: 609850(ECHDC1)
AML: 100469062(ECHDC1)
UMR: 103663427(ECHDC1)
ORO: 101378337(ECHDC1)
FCA: 101086310(ECHDC1)
PTG: 102958239(ECHDC1)
AJU: 106976806(ECHDC1)
BTA: 536284(ECHDC1)
BOM: 102265974(ECHDC1)
BIU: 109563748(ECHDC1)
PHD: 102336638(ECHDC1)
CHX: 102178542(ECHDC1)
OAS: 101116321(ECHDC1)
SSC: 100512509(ECHDC1)
CFR: 102518806(ECHDC1)
CDK: 105096326(ECHDC1)
BACU: 103017976(ECHDC1)
LVE: 103078139(ECHDC1)
OOR: 101270675(ECHDC1)
ECB: 100073045(ECHDC1)
EPZ: 103567873(ECHDC1)
EAI: 106838298 106838937(ECHDC1)
MYB: 102258272(ECHDC1)
MYD: 102751783(ECHDC1)
HAI: 109392627(ECHDC1)
RSS: 109446256(ECHDC1)
PALE: 102893310(ECHDC1)
LAV: 100657207(ECHDC1)
TMU: 101346877
MDO: 100030825(ECHDC1)
SHR: 100919338(ECHDC1)
GGA: 769021(ECHDC1)
MGP: 100546546
CJO: 107311738(ECHDC1)
APLA: 101804132(ECHDC1)
ACYG: 106032483(ECHDC1)
TGU: 100227322(ECHDC1)
GFR: 102044218(ECHDC1)
FAB: 101806230(ECHDC1)
PHI: 102113663(ECHDC1)
PMAJ: 107201912(ECHDC1)
CCW: 104690802(ECHDC1)
FPG: 101918396(ECHDC1)
FCH: 102055851(ECHDC1)
CLV: 102084911(ECHDC1)
EGZ: 104131447 104131979(ECHDC1)
AAM: 106497960(ECHDC1)
ASN: 102383062(ECHDC1)
AMJ: 102560692(ECHDC1)
PSS: 102451093(ECHDC1)
CMY: 102945116(ECHDC1)
CPIC: 101939758(ECHDC1)
ACS: 100552293(echdc1)
PVT: 110077561(ECHDC1)
PBI: 103055176(ECHDC1)
GJA: 107121808(ECHDC1)
XLA: 496330(echdc1.L)
XTR: 496886(echdc1)
NPR: 108795294(ECHDC1)
DRE: 553585(echdc1)
SANH: 107688988(echdc1)
CCAR: 109098239(echdc1)
IPU: 108270580(echdc1)
AMEX: 103032922(echdc1)
TRU: 101067683(echdc1)
LCO: 104926210(echdc1)
NCC: 104955220(echdc1)
MZE: 101482663(echdc1)
OLA: 101165254(echdc1)
XMA: 102231312(echdc1)
PRET: 103478333(echdc1)
NFU: 107378790(echdc1)
CSEM: 103388602(echdc1)
LCF: 108888597(echdc1)
BPEC: 110171745(echdc1)
ELS: 105023514(echdc1)
SFM: 108937328(echdc1)
LCM: 102352882(ECHDC1)
CMK: 103182298(echdc1)
SPU: 584418
APLC: 110980172
TCA: 659052
NVL: 108560577
DNX: 107166647
ZNE: 110830973
FCD: 110851854
TUT: 107363239
CEL: CELE_C32E8.9(C32E8.9)
CBR: CBG12007
CRG: 105325046
MYI: 110456022
OBI: 106867393
EPA: 110242745
ADF: 107335744
HMG: 100209361
SPAR: SPRG_12932
ECO: b2919(scpB)
ECJ: JW2886(ygfG)
ECD: ECDH10B_3094(ygfG)
EBW: BWG_2642(scpB)
ECOK: ECMDS42_2419(ygfG)
ECE: Z4256(ygfG)
ECS: ECs3789
ETW: ECSP_3885(ygfG)
EOJ: ECO26_4006(scpB)
EOI: ECO111_3655(scpB)
EOH: ECO103_3493(scpB)
ECOO: ECRM13514_3779(ygfG)
ECOH: ECRM13516_3640(ygfG)
EOK: G2583_3573(scpB)
ESO: O3O_20775
ESM: O3M_04920
ESL: O3K_04875
ELH: ETEC_3111
ECY: ECSE_3181
ECR: ECIAI1_3039(ygfG)
ECK: EC55989_3207(ygfG)
ECT: ECIAI39_3333(ygfG)
EOC: CE10_3355(scpB)
EUM: ECUMN_3263(ygfG)
ELO: EC042_3128(mmcD)
EBR: ECB_02750(ygfG)
EBD: ECBD_0819
EKF: KO11_08175(scpB)
EDJ: ECDH1ME8569_2820(scpB)
ELW: ECW_m3174(scpB)
ELL: WFL_15495(scpB)
EBL: ECD_02750(scpB)
EBE: B21_02713(scpB)
SBG: SBG_2660(scpB)
SBZ: A464_3077
SFL: SF2904(ygfG)
SFX: S3104(ygfG)
SFV: SFV_2965(ygfG)
SFE: SFxv_3183(scpB)
SFN: SFy_4135
SFS: SFyv_4211
SFT: NCTC1_03195(scpB)
SSN: SSON_3070(ygfG)
SBO: SBO_3075(ygfG)
KOX: KOX_02550
KOE: A225_4950
YEN: YE1894
YEY: Y11_07661
YEW: CH47_1328
YET: CH48_3601
YIN: CH53_4254
YRO: CH64_767
PANR: A7J50_3333
BCN: Bcen_0459
BCJ: BCAL3068(mmcD)
BCEN: DM39_762
BCEO: I35_0800(mmcD)
BCT: GEM_2591
BCED: DM42_900
BCON: NL30_11120
BSEM: WJ12_04245
BPSL: WS57_22190
BMEC: WJ16_04320
BXE: Bxe_B2996
BXB: DR64_5326
PNU: Pnuc_1611
CARE: LT85_0269
LCH: Lcho_2461
DSU: Dsui_3389
AZA: AZKH_2453
GUR: Gura_3534
GLO: Glov_1378
GBM: Gbem_0684
GEM: GM21_0696
GEB: GM18_3668
RVA: Rvan_2264
FIL: BN1229_v1_3813(ygfG)
FIY: BN1229_v1_3803(ygfG)
MAG: amb2242
MAGX: XM1_3062(ygfG)
MAGN: WV31_08090
PUF: UFO1_4601
PFT: JBW_00291
 » show all
Taxonomy
Reference
1  [PMID:5646172]
  Authors
Galivan JH, Allen SH.
  Title
Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus.
  Journal
J Biol Chem 243:1253-61 (1968)
Reference
2  [PMID:7070502]
  Authors
Hilpert W, Dimroth P.
  Title
Conversion of the chemical energy of methylmalonyl-CoA decarboxylation into a Na+ gradient.
  Journal
Nature 296:584-5 (1982)
Reference
3  [PMID:2920730]
  Authors
Hoffmann A, Hilpert W, Dimroth P.
  Title
The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens.
  Journal
Eur J Biochem 179:645-50 (1989)
DOI:10.1111/j.1432-1033.1989.tb14596.x
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.41
IUBMB Enzyme Nomenclature: 4.1.1.41
ExPASy - ENZYME nomenclature database: 4.1.1.41
BRENDA, the Enzyme Database: 4.1.1.41
CAS: 37289-44-4

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