KEGG   ENZYME: 4.1.1.43Help
Entry
EC 4.1.1.43                 Enzyme                                 

Name
phenylpyruvate decarboxylase;
phenylpyruvate carboxy-lyase;
phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
3-phenyl-2-oxopropanoate carboxy-lyase (phenylacetaldehyde-forming)
Reaction(IUBMB)
phenylpyruvate = phenylacetaldehyde + CO2 [RN:R01377]
Reaction(KEGG)
R01377;
(other) R01974
Show
Substrate
phenylpyruvate [CPD:C00166]
Product
phenylacetaldehyde [CPD:C00601];
CO2 [CPD:C00011]
Comment
The enzyme from the bacterium Azospirillum brasilense also acts on some other substrates, including (indol-3-yl)pyruvate, with much lower efficiency. However, it only possesses classical Michaelis-Menten kinetics with phenylpyruvate. Aliphatic 2-oxo acids longer that 2-oxohexanoate are not substrates. cf. EC 4.1.1.74, indolepyruvate decarboxylase.
History
EC 4.1.1.43 created 1972
Pathway
ec00360  Phenylalanine metabolism
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:4303395]
  Authors
Asakawa T, Wada H, Yamano T.
  Title
Enzymatic conversion of phenylpyruvate to phenylacetate.
  Journal
Biochim Biophys Acta 170:375-91 (1968)
DOI:10.1016/0304-4165(68)90017-2
Reference
2  [PMID:17766418]
  Authors
Spaepen S, Versees W, Gocke D, Pohl M, Steyaert J, Vanderleyden J
  Title
Characterization of phenylpyruvate decarboxylase, involved in auxin production of Azospirillum brasilense.
  Journal
J Bacteriol 189:7626-33 (2007)
DOI:10.1128/JB.00830-07
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.43
IUBMB Enzyme Nomenclature: 4.1.1.43
ExPASy - ENZYME nomenclature database: 4.1.1.43
BRENDA, the Enzyme Database: 4.1.1.43
CAS: 37289-45-5

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